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Definition of the noun 90Y-DOTA-Biotin
What does 90Y-DOTA-Biotin mean as a name of something?
- [oncology] The vitamin biotin labelled with radioactive (yttrium-90); it is used in the treatment of cancer where it seeks out tumor cells that have been targeted by an antibody linked to strepavidin and kill them.
- 90Y-DOTA-biotin: ⁹⁰Y-DOTA-biotin consists of a radioactive substance complexed by a chelating agent, which in turn is attached to the vitamin biotin via a chemical linker. It is used experimentally in pretargeted radioimmunotherapy. Animal studies have been conducted as well as clinical studies in humans.
- 90Y-DOTA-Biotin: A radioimmunoconjugate of biotin conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid and labeled with beta-emitting radioisotope yttrium 90. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. 90Y-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin.
Printed dictionaries and other books with definitions for 90Y-DOTA-Biotin
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Cancer Dictionary (2004)
by Henry A. Rose
90Y-DOTA-biotin A radioactive substance (yttrium-90) joined by a large chemical link (DOT A) to biotin, a vitamin.
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Video about 90Y-DOTA-Biotin
Video shows what 90Y-DOTA-biotin means. The vitamin biotin labelled with radioactive (yttrium-90), used in the treatment of cancer, where it seeks out tumor ...