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Abciximab

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Definition of the noun Abciximab

What does Abciximab mean as a name of something?

noun

  1. [pharmaceutical drug] An antiplatelet drug used to reduce the risk of a heart attack during coronary surgery.

Explanation

Abciximab, a glycoprotein IIb/IIIa receptor antagonist manufactured by Janssen Biologics BV and distributed by Eli Lilly under the trade name ReoPro, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus formation within the coronary artery. It is a glycoprotein IIb/IIIa inhibitor.

Printed books with definitions for Abciximab

Click on a title to look inside that book (if available):

Google previewCardiovascular Catheterization and Intervention (2017)

A Textbook of Coronary, Peripheral, and Structural Heart Disease, Second Edition by Debabrata Mukherjee, Eric R. Bates, Marco Roffi, Richard A. Lange, David J. Moliterno

Since abciximab is an antibody, immunemediated thrombocytopenia may occur, especially with repeated use.71 Eptifibatide and tirofiban are both small- molecule GP IIb/IIIa inhibitors. Tirofiban is a highly specific peptidomimetic, and ...

Google previewPrinciples of Pharmacology (2011)

The Pathophysiologic Basis of Drug Therapy by Armen H. Tashjian, Ehrin J. Armstrong

Abciximab is a chimeric mouse-human monoclonal antibody directed against the human GPIIb-IIIa receptor.

Because abciximab is an irreversible inhibitor of platelet function, and all the abciximab previously infused is already bound to ...

Google previewAtherothrombosis in Clinical Practice (2013)

by Deepak L. Bhatt

Abciximab is a humanized monoclonal antibody that ...

Google previewPlatelet Function (2007)

Assessment, Diagnosis, and Treatment by Martin Quinn, Desmond Fitzgerald, Dermott Cox

Abcizimab Abciximab is a human chimericantibody fragment that binds to both active and inactive Omb|33 integrin with high affinity. It is relatively nonselective, also adhering to other integrins: vitronectin (ovs53) receptors on smooth muscle ...

Google previewPharmacology - Volume I (2009)

by Harry Majewski

Abciximab is an antibody to the GPIIb/IIIa receptor, and acts as an antagonist. Abciximab is used in combination with aspirin and the anticoagulant heparin, when angioplasty or stenting is undertaken for coronary thrombosis. When abciximab ...

Google previewCardioprotection (2009)

by Derek Hausenloy, Derek Yellon

Glycoprotein IIb/IIIa inhibitors Abciximab is a monoclonal antibody directed at the glycoprotein (GP) IIb-IIIa ...

Google previewBrody's Human Pharmacology (2009)

by Lynn Wecker, Stephanie Watts, Carl Faingold, George Dunaway, Lynn Crespo

Lower right: Abciximab is a Fab fragment of a chimeric human-murine monoclonal antibody. The variable (V) and constant (C) regions of the light (L) and heavy (H1) chains are shown. monitoring of prothrombin time (PT), a standard laboratory ...

Google previewSCAI Interventional Cardiology Board Review (2013)

by Morton J. Kern

There are three parenteral GP IIb/IIIa antagonists approved for clinical use: abciximab, eptifibatide, and tirofiban. Abciximab is a large chimeric monoclonal antibody with a high binding affinity that results in a prolonged pharmacological effect ...

Google previewAcute Coronary Syndrome - ECAB (2012)

by R R Kasliwal

Abciximab is a Fab fragment of a humanized murine antibody that has a short plasma half-life of 10 minutes but strong affinity for the receptor. Platelet aggregation gradually returns to normal 24–48 hours after discontinuation of the drug.

Google previewMedical Pharmacology and Therapeutics (2013)

by Derek G. Waller, Tony Sampson

Abciximab is an antibody, tirofiban a non-peptide inhibitor and eptifibatide a peptide inhibitor of these glycoprotein receptors. Epoprostenol and dipyridamole inhibit activation of platelets and downregulate the glycoprotein receptors by ...

Google previewTrounce's Clinical Pharmacology for Nurses (2008)

by Clive P. Page, Ben Greenstein, Dinah Gould

Abciximab is an interesting drug, whose development reflects a radically new approach to the treatment of disease .

Google previewAvoiding Common ICU Errors (2012)

by Lisa Marcucci, Elizabeth A. Martinez, Elliott R. Haut, Anthony D. Slonim, Jose I. Suarez

Abciximab is a monoclonal antibody with a high affinity for both activated and resting platelets, whereas eptifibatide and tirofiban are nonantibody receptor inhibitors with less affinity for resting platelets and much faster dissociation rates ...

Google previewMEDICAL AND HEALTH SCIENCES - Volume XI (2010)

by Osmo Otto Paivio Hanninen; Mustafa Atalay; B.P. Mansourian; A. Wojtezak; S.M. Mahfouz; Harry Majewski; Elaine Elisabetsky; Nina L. Etkin; Ralph Kirby; T.G. Downing and M.I. El Gohary

Abciximab is an antibody to the GPIIb/IIIa receptor, and acts as an antagonist. Abciximab is used in combination with aspirin and the anticoagulant heparin, when angioplasty or stenting is undertaken for coronary thrombosis. When abciximab ...

Google previewEssentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care (2014)

by Alan David Kaye, Adam M. Kaye, Richard D. Urman

Abciximab is a monoclonal antibody that targets the integrin glycoprotein IIb/IIIa receptor complex, which induces platelet aggregation by cross-linking receptors on nearby platelets when activated. A randomized double-blind clinical trial ...

Google previewComprehensive Coronary Care (2007)

by Nigel I. Jowett, David R. Thompson

Three agents are available for use: abciximab, eptifibatide and tirofiban. Abciximab is a monoclonal antibody used ...

Google previewTextbook of Coronary Thrombosis and Thrombolysis (2008)

by R. C. Becker

Whereas abciximab is a noncompetitive inhibitor of GPIIb/IIIa, and also acts against other cell receptors, the synthetic inhibitors are competitive inhibitors and highly selective against GPIIb/IIIa. Given the impressive clinical results of abciximab, ...

Google previewPerioperative Medicine (2007)

Managing for Outcome by Mark F. Newman, Lee A Fleisher, Mitchell P. Fink

Abciximab is a noncompetitive inhibitor of glycoprotein IIb/IIIa that forms a high- avidity ...

Google previewConcise Clinical Pharmacology (2007)

by Ben Greenstein, Adam Greenstein

Abciximab is a monoclonal antibody that binds to and dissociates slowly from the receptor. Eptifibatide is a peptide that binds to and dissociates rapidly from the receptor. Both drugs are administered by initial intravenous injection followed by ...

Google previewClinical Cardiology (2016)

Current Practice Guidelines by Demosthenes Katritsis, A. John Camm, Bernard J. Gersh

Abciximab is a Fab fragment that targets the glycoprotein IIb/IIIa receptor and may be specifically used in percutaneous coronary intervention. The small molecule inhibitors eptifibatide and tirofiban are short-acting and require dose adjustment ...

Google previewCardiovascular Interventions in Clinical Practice (2010)

by Jürgen Haase, Hans-Joachim Schäfers, Horst Sievert, Ron Waksman

Abciximab is a fragment antigen binding (Fab fragment) fragment of a humanized murine antibody that has a short plasma half-life with a strong affinity for the GP IIb/IIIa receptor. Platelet...

Therefore, abciximab is an appropriate choice for ...

Google previewDesk Reference of Clinical Pharmacology, Second Edition (2007)

by Manuchair Ebadi

ABCIXIMAB (ReoPro) Abciximab is a glycoprotein IIb/IIIa inhibitor and binds to glycoprotein IIb/IIIA receptors on the surface of platelets, thereby preventing platelet aggregation. It is used as an adjunct to precutaneous coronary intervention ...

Google previewOxford Desk Reference: Cardiology (2011)

by Hung-Fat Tse, Gregory Y. Lip, Andrew J. Stewart Coats

Abciximab is a Fab fragment of himeric human–murine monoclonal antibody 7E3. Abciximab binds to GP IIb/IIIa and vitronectin platelet receptors, completely preventing platelet aggregation. Abciximab is indicated as an adjunct to ...

Google previewEndovascular Surgery E-Book (2010)

by Wesley S. Moore

Abciximab is a platelet aggregation inhibitor primarily used during and after coronary artery procedures such as angioplasty but also may be used during peripheral angioplasty procedures.

Google previewTextbook of Critical Care (2015)

Two Volume Set by Yatin Mehta, Mukesh Gupta

Abciximab is an irreversible, noncompetitive inhibitor that is unlike the small molecule inhibitors because it works through steric hindrance of the receptor site, thereby blocking the binding of fibrinogen and vWF to the GP-IIb/IIIa receptor ...

Google previewLippincott's Illustrated Q&A Review of Pharmacology (2013)

by Stanley Zaslau

Abciximab is a monoclonal antibody that binds to glycoprotein receptor IIb/IIIa to inhibit plate— let aggregation. (B) The mechanism of action of clopidogrel is irreversibly block ADP receptors on platelets to prevent platelet aggregation.

Google previewClinical Pharmacy and Therapeutics (2011)

by Roger Walker

Abciximab is a monoclonal antibody which binds to coronary glycoprotein IIb/IIIa receptors and to other related sites. It is licensed as an adjunct to heparin and aspirin for the prevention of ischaemic complications in highrisk patients ...

Google previewAnesthesia and Uncommon Diseases (2012)

by Lee A Fleisher

Of the three intravenous GPIIbIIIa inhibitors, abciximab is a large monoclonal antibody (mAb) that binds and causes permanent dysfunction of the GPIIbIIIa receptor, ...

Google previewCoronary Stenting: A Companion to Topol's Textbook of Interventional Cardiology E-Book (2013)

by Matthew J. Price

Abciximab is a large chimeric monoclonal antibody with a high binding affinity that results in a prolonged pharmacologic effect.35 It is a monoclonal antibody that is a Fab (fragment antigen binding) fragment of a chimeric human-mouse ...

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Scrabble value of A1B3C3I1X8I1M3A1B3

The value of this 9-letter word is 24 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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