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Header of Acantholysis


Definition of the noun acantholysis

What does acantholysis mean as a name of something?

noun - plural: -

  1. a breakdown of a cell layer in the epidermis (as in pemphigus)
    • lexical domain: States - nouns denoting stable states of affairs
    • more generic terms: disease of the skin / skin disease / skin disorder = a disease affecting the skin
    • part of: pemphigus = a skin disease characterized by large thin-walled blisters (bullae) arising from normal skin or mucous membrane

Alternative definition of the noun acantholysis


  1. [medicine] The loss of intercellular connections, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris.

Printed dictionaries and other books with definitions for Acantholysis

Click on a title to look inside that book (if available):

Google previewPathology of Domestic Animals (2013)

by K. V.F. Jubb

Acantholysis is a loss of cohesion between epidermal cells resulting in intraepidermal clefts, vesicles, and bullae (Fig. 5.8). This process may also involve the outer root sheath of hair follicles and glandular ductal epithelium. Acantholysis is ...

Google previewOral Pathology, Clinical Pathologic Correlations (2016)

Medicine, Internal medicine by CTI Reviews

Acantholysis is the loss of intercellular connections resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris. This histological feature is also seen in herpes simplex infections (HSV 1 and 2). Measles is ...

Google previewPractical Dermatopathology (2012)

by Ronald P. Rapini

Acantholysis Acantholysis is the loss of cohesion between keratinocytes as a result of dissolution of intercellular connections, sometimes resulting in an intraepidermal vesicle.

Google previewAndrew's Diseases of the Skin (2011)

Clinical Dermatology by William D. James, Timothy Berger, Dirk Elston

Acantholysis is an uncommon finding but may be present. The inflammatory infiltrate in the dermis is composed of mononuclear cells and is generally mild. Specimens should be obtained from skin sites where hair follicles are numerous.

Google previewLever's Histopathology of the Skin (2009)

by David E. Elder, Rosalie Elenitsas, Bernett L. Johnson, George F. Murphy

Acantholysis is the most prominent feature. The pattern may resemble that of pemphigus vulgaris, pemphigus vegetans, pemphigus foliaceus, or benign familial pemphigus (45).Acantholysis may be combined with dyskeratosis, in which case ...

Google previewSide-Effects of Anti-Inflammatory Drugs (2012)

Part Two Studies in Major Organ Systems by K. D. Rainsford, G. P. Velo

Acantholysis is a typical though not pathognomonic histological abnormality of pemphigus that is also to be seen ...

Google previewInflammatory Dermatopathology (2016)

A Pathologist's Survival Guide by Steven D. Billings, Jenny Cotton

Acantholysis is the result of loss of appropriate keratinocyte–keratinocyte adherence. This adherence is mediated by tight junctions, adherens junctions, gap junctions, and desmosomes. Desmosomes are critical to keratinocyte adhesion, and ...

Google previewOrigin and Continuity of Cell Organelles (2013)

by J. Reinert, H. Ursprung

Acantholysis is a condition, of multiple origin, in which the epidermis loses its compact histological structure and fluid spaces (blisters) appear. WILGRAM and CAULFIELD (1965) studying a variety of acantholytic diseases, reported graded ...

Google previewUSMLE Images for the Boards (2012)

A Comprehensive Image-Based Review by Amber S. Tully, James S. Studdiford

Definitive diagnosis via punch biopsy □ Treatment with corticosteroids and immunosuppressive drugs □ Acantholysis is the breaking apart of epidermal cells. □ Both cutaneous and mucosal lesions □ Flaccid bullae □ Positive Nikolsky sign ...

Google previewHistology for Pathologists (2016)

Medicine, Internal medicine by CTI Reviews

Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris. It is absent in bullous pemphigoid, making it useful for differential ...

Google previewAn Aid to the MRCP Short Cases (2009)

by Robert E. J. Ryder, M. Afzal Mir, E. Anne Freeman

Acantholysis is a characteristic histological feature. Nikolsky's sign* is invariably present. Immunofluorescence of biopsy shows intercellular immunoglobulins ( usually IgG) and/or complement factor C3. Pemphigoid: the site of the blisters is at ...

Google previewBasic and Clinical Immunology (2016)

Medicine, Allergology by CTI Reviews

Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris.

Google previewDermatology (2012)

by Jean L. Bolognia, Joseph L. Jorizzo, Julie V. Schaffer

acantholysis, ballooning degeneration. Acantholysis refers to discohesion of keratinocytes as a consequence of the disruption of desmosomes (intercellular connections) and this can lead to an ...

Google previewDiagnostic Atlas of Common Eyelid Diseases (2007)

by Jonathan J. Dutton, Gregg S. Gayre, Alan D. Proia

Acantholysis is the loss of cohesion between epidermal (or epithelial) cells leading to the formation of intraepidermal clefts, vesicles, or bullae. Primary acantholysis results from dissolution or separation of the desmosomes ...

Google previewRook's Textbook of Dermatology, 4 Volume Set (2016)

by Christopher Griffiths, Jonathan Barker, Tanya Bleiker, Robert Chalmers, Daniel Creamer

Acantholysis is the term used to describe a loss of cohesion between keratinocytes due to the break down of intercellular bridges. It results in the formation of intraepidermal clefts, vesicles and bullae. It appears to be the primary ...

Google previewAn Illustrated Dictionary of Dermatologic Syndromes, Second Edition (2006)

by Susan B. Mallory

Histology: granular cell layer acantholysis DIF: IgG, C3 or both along keratinocyte surfaces Pemphìgus erythematosus SYN; seNEAR-usHER SYNDROME Clinical features of lupus erythematosus with lesions on face with erythema and scaling ...

Google previewConcise Dictionary of Modern Medicine (2010)

by Joseph Segen

acantholysis. Dermatology The pathologic disruption of intercellular bridges between keratinocytes in the squamous epithelium of mucocutaneous surfaces, resulting in intraepithelial vesicles Diseases with Pemphigus vulgaris, benign familial ...

Google previewEncyclopedia of Cell Biology (2015)

These inhibit desmosomal adhesion causing loss of cell–cell adhesion ( acantholysis) that manifests as blistering of the skin and mucosae. One mechanism for these autoantibodies to disrupt adhesion is by inducing the downregulation of Dsg ...

Google previewA Dictionary of Medicine (1894)

Including General Pathology, General Therapeutics, Hygiene, and the Diseases of Women and Children by Sir Richard Quain

ACANTHOLYSIS. — An acanthosis characterized by separation of the upper layers of the epidermis — as pemphigus essentialis and gangrsena cachectica infantum. ACANTHOMA. — Hyperplasia of the prickle-cell layer of the epidermis.

Google previewThe Encyclopedia of Neuropsychological Disorders (2012)

by Chad A. Noggle, Arthur MacNeill Horton

Skin biopsy: histology shows keratinocyte necrosis, epidermal acantholysis, and IgG and complement deposition in epidermal and basement membrane Zones Cyclophosphamide ...

Google previewA Gateway to MDS- Encyclopedia of MCQs in Dental Sciences (Vol 2 : Basic) : 2005 (2005)

Acantholysis A. Pemphigus C Sub-epithelial vesicles B. Psoriasis D. Apusitzsign C Lichenplanus D. Erythema multiforme 314. Nikolsky's sign is positive ...

Google previewDictionary of Practical Surgery (1886)

by Christopher Heath

Acantholysis, ii. 180 Acarus ...

Google previewConcise Pocket Medical Dictionary (2015)

by UN Panda

Acantholysis A term used in dermal pathology to denote dissolution of the layers of the epidermis. It is seen in such conditions as pemphigus vulgaris and keratosis follicularis. Acanthoma Well differentiated a. keratinizing cornifying squamous ...

Google previewA Dictionary of Dentistry (2010)

by Robert Ireland

acantholysis n. The breakdown of epidermal or epithelial cells due to a loss of intercellular substance . It is often seen in conditions such as *pemphigus vulgaris, where it is caused by ...

Google previewConcise Dictionary of Biomedicine and Molecular Biology (2001)

by Pei-Show Juo

Acantholysis Destruction of the epidermis. Acanthoma Carcinoma of the epidermis or tumor of the skin. Acanthosis The thickening and warty growth of the prickle-cell layer of the skin, e.g., eczema and psoriasis. Acapnia A marked decrease of ...

Google previewMosby's Dictionary of Medicine, Nursing and Health Professions - Australian & New Zealand Edition (2014)

by Peter Harris, Sue Nagy, Nicholas Vardaxis

acantholysis /akމantholމisis/, loss of cohesion between keratinocytes, sometimes resulting in an intraepidermal blister. The cells are rounded.

Google previewIllustrated Encyclopedia of Dermatology (2012)

by Lionel Fry, Fenella Wojnarowska, Parvin Shahrad

Histology will show an intraepidermal blister, and socalled acantholysis, in which the epidermal cells drift apart from each other, and the space between them becomes filled with fluid.

Google previewThe Illustrated Doctors Dictionary (2011)

A medical dictionary written by a doctor for doctors, now illustrated by Joseph C Segen

Cf Bullous pemphigoid Pathology Acantholysis.

Google previewEncyclopedia of Toxicology (2005)

by Bruce Anderson, Ann de Peyster, Shayne C. Gad, P.J. Bert Hakkinen, Michael Kamrin, Betty Locey, Harihara M. Mehendale, Carey Pope, Lee Shugart

Following an oral gavage for 90 days, the noeffect dose is 8mgkg −1 day −1 , with severe forestomach tissue lesions characterized by inflammation, necrosis, acantholysis, hyperkeratosis, and epithelial hyperplasia. Mice exposed to 8ppm ...

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Scrabble value of A1C3A1N1T1H4O1L1Y4S1I1S1

The value of this 12-letter word is 20 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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