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Acarbose

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Definition of the noun Acarbose

What does Acarbose mean as a name of something?

noun

  1. An antidiabetic drug that inhibits alpha glucosidase.

Explanation

Acarbose: A complex oligosaccharide used as a hypoglycemic agent in diabetes management. Acarbose inhibits enzymes required in catabolism of carbohydrates, specifically pancreatic alpha-amylase, which hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine, and the membrane-bound intestinal alpha-glucosidases, which hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the small intestine. When acarbose is orally administered, less digestion of complex carbohydrates occur and less glucose is absorbed in the small intestine, thereby producing a smaller rise in postprandial blood glucose levels after a carbohydrate load.

  • also known as Glucobay

Printed books with definitions for Acarbose

Click on a title to look inside that book (if available):

Google previewMosby's 2015 Nursing Drug Reference (2016)

by CTI Reviews

Acarbose is an antidiabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes. It is sold in Europe under the brand name Glucobay (Bayer AG), in North America as Precose and in Canada as Prandase (Bayer AG) .

Google previewThe Insulin Resistance Solution (2016)

Reverse Pre-Diabetes, Repair Your Metabolism, Shed Belly Fat, and Prevent Diabetes - with more than 75 recipes by Dana Carpender by Rob Thompson, Dana Carpender

Acarbose is a natural substance produced by bacteria in soil. It's simply a small piece of starch modified in such a way that when amylase tries to break it down, it ties up the amylase and takes it out of action. Enough amylase remains to digest ...

Google previewPrevention of Type 2 Diabetes (2012)

From Science to Therapy by Derek LeRoith

Acarbose is a competitive inhibitor of the a-glucosidases of the brush border of the small intestine, enzymes that are necessary for the hydrolysis of the disaccharides, oligosaccharides and polysaccharides to monosaccharides for absorption ...

Google previewMarks' Basic Medical Biochemistry (2012)

by Alisa Peet

CH2OH CH2OH O OH OH O OH OH O O n Acarbose is an FDA-approved drug that blocks the activities of pancreatic -amylase and brush border -glucosidases ( with specificity for glucose). The drug is produced from a microorganism and is a ...

Google previewBiochemical, Physiological, and Molecular Aspects of Human Nutrition - E-Book (2013)

by Martha H. Stipanuk, Marie A. Caudill

Acarbose is the most widely used α-glucosidase inhibitor currently on the market (Figure 8-8). Acarbose is an efficient inhibitor of α-amylase and of the C-terminal ...

Google previewHormone Replacement Therapy (1999)

by A. Wayne Meikle

Like metformin, acarbose is a useful agent in treating patients with type 2 diabetes who develop hypoglycemia on even low doses of sulfonylureas. Because acarbose is absorbed to a minimal extent from the gastrointestinal tract, it is a safe ...

Google previewTextbook of Medicinal Chemistry (2012)

by V Alagarsamy

Properties and uses: Acarbose is a white or yellowish amorphous hygroscopic powder, very soluble in water, soluble in methanol, and practically insoluble in methylene chloride. It is an alpha-glucosidase inhibitor and used in the treatment of ...

Google previewHandbook of Drug Administration via Enteral Feeding Tubes, 3rd edition (2015)

by Rebecca White, Vicky Bradnam

Acarbose is a reversible, competitive inhibitor of the alpha-glycoside hydrolases of the small-intestinal brush border. Health and safety Standard precautions apply. Suggestions/recommendations • Owing to its mechanism of action, acarbose ...

Google previewPassing the FRACP Written Examination (2013)

Questions and Answers by Jonathan Gleadle, Tuck Yong, Jordan Li, Surjit Tarafdar, Danielle Wu

Acarbose is a man-made oligosaccharide designed to slow down the actions of alpha-amylase and alpha-glucosidase enzymes, thereby slowing the absorption of sugar after the meal. In a patient receiving pancreatic enzyme supplement due ...

Google previewMedical-Surgical Nursing, Critical Thinking in Patient Care (2016)

Nursing, Medical-surgerical nursing by CTI Reviews

Acarbose: Acarbose is an antidiabetic drug used totreat type2 diabetes mellitusand, in some countries,prediabetes. Itissold in Europe under thebrand name Glucobay (Bayer AG), in North America as Precose (Bayer Pharmaceuticals), and in ...

Google previewInstant Pharmacology (1999)

by Kourosh Saeb-Parsy

Acarbose is an oral hypoglycaemic agent which inhibits a- glucosidase. USES: Acarbose is occasionally used as an adjunct to other oral hypoglycaemic agents in the management of diabetes mellitus. MECHANISM OF ACTION: ...

Google previewPharmacology in Rehabilitation (2016)

by CTI Reviews

Precose: Acarbose is an antidiabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes. It is sold in Europe under the brand name Glucobay (Bayer AG), in North Americaas Precoseand in Canada asPrandase ...

Google previewPolycystic Ovary Syndrome (2013)

Current and Emerging Concepts by Lubna Pal

Acarbose is a complex oligosaccharide inhibiting alpha-glucosidase and, hence, decreasing digestion of polysaccharides, reducing glucose absorption, and lowering postprandial insulin levels [64]. Clinical data about the effect of acarbose ...

Google preview320 Single Best Answer Questions for Final Year Medical Students (2016)

by Adam Ioannou

Acarbose is an alpha-glucosidase inhibitor and is used to inhibit the breakdown of starch. It's side effects include abdominal pain and diarrhoea. Simvastatin is a statin and acts as a HMG CoA reductase inhibitor, and it can cause myositis and ...

Google previewThe Final Hurdle (2011)

Single Best Answers in Clinical Pharmacology and Therapeutics by Shamik Dholakia, Chris John, Michael Schachter

Acarbose is an inhibitor of alpha glucosidase enzymes that act on the brush border of the small intestine reducing the rate of digestion and absorption of glucose. It is a good adjunct to other oral hypoglycaemic therapy, especially with the ...

Google previewMosby's Pharmacy Review for the NAPLEX (2010)

by Mosby

Metformin is a biguanide that decreases glucose production in the liver and Acarbose is an alpha-glucosidase inhibitor that decreases oral glucose aborption . 20. E. Rationale: There are various oral medications used to treat type 2 diabetes.

Google previewObesity and Diabetes (2009)

by Tony Barnett, Sudhesh Kumar

Acarbose is an a-glucosidase inhibitor that inhibits the breakdown of some complex sugars to glucose within the intestinal lumen, thus reducing the rise in glucose seen after a carbohydrate meal. This undigested carbohydrate is ...

Google previewNutraceuticals, Glycemic Health and Type 2 Diabetes (2009)

by Vijai K. Pasupuleti, James W. Anderson

Acarbose is an alpha-glucosidase inhibitor that slows the breakdown of disaccharides in the gut, resulting in decreased postprandial hyperglycemia, improved insulin sensitivity, and reduced stress on beta cells. A trial to prevent ...

Google previewGlycoproteins (1995)

by Jean Montreuil

The pseudo-tetrasaccharide, acarbose is a strong inhibitor of pig pancreatic a-amylase [71] and X-ray analysis of the crystal showed a well- defined density corresponding to five fully occupied subsites in the active site.

Google previewPharmacology, Principles and Applications (2016)

by CTI Reviews

Acarbose is an antidiabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay (Bayer AG), in North America as Precose (Bayer Pharmaceuticals), ...

Google previewType 2 Diabetes (2016)

Principles and Practice, Second Edition by Barry J. Goldstein, Dirk Mueller-Wieland

Acarbose is a pseudotetrasaccharide with a nitrogen bound between the first and second glucose unit. This modification of a natural tetrasaccharide is important for its high affinity for active centers of alpha-glucosidases of the brush border of ...

Google previewMedical Toxicology (2004)

by Richard C. Dart

O-GLUCOSIDASE INHIBITORS Acarbose is a complex pseudotetrasaccharide obtained from the fermentation processes of the microorganism Actinoplanes utahensis (10,11). Acarbose competitively and reversibly inhibits the O- glucosidase ...

Google previewMetabolic Medicine and Surgery (2014)

by Michael M. Rothkopf, Michael J. Nusbaum, Lisa P. Haverstick, RDN, CNSC

Acarbose is an agent that competitively and reversibly inhibits pancreatic α- amylase and intestinal α-glucosidase in the intestinal brush border [37]. This delays carbohydrate absorption, leading to lower postprandial insulin and glucose levels.

Google previewScully's Medical Problems in Dentistry (2014)

by Crispian Scully

Acarbose is an alpha- glucosidase ...

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Acarbose Meaning

Video shows what acarbose means. An antidiabetic drug that inhibits alpha glucosidase.. acarbose synonyms: Precose. Acarbose Meaning. How to pronounce ...

Scrabble value of A1C3A1R1B3O1S1E1

The value of this 8-letter word is 12 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

Anagrams of ACARBOSE

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