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Aciclovir: A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses. After conversion in vivo to the active metabolite acyclovir triphosphate, acyclovir competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the thymidine kinase of HSV.

  • also known as Acyclovir, Acycloguanosine

Printed dictionaries and other books with definitions for Aciclovir

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Google previewFundamentals of Pharmacology (2015)

An Applied Approach for Nursing and Health by Alan Galbraith, Shane Bullock, Elizabeth Manias, Barry Hunt, Ann Richards

Resistance to aciclovir is an emergent cause of con- cern; this may also eventuate with famciclovir. Resistant cases can be treated with foscarnet (see below). Oral ganciclovir must be taken with or after food to maximise absorption. This drug ...

Google previewManual of Dentistry (2016)

by Irena Baumruková

Aciclovir is a drug used in the management ...

Google previewEssentials of Organic Chemistry (2013)

For Students of Pharmacy, Medicinal Chemistry and Biological Chemistry by Paul M. Dewick

O HO HOH 2 C N NH N O N NH 2 2 ́-deoxyguanosine N HOH2C N O NH N NH2 aciclovir Aciclovir is a member of a group of nucleoside derivatives termed acyclonucleosides,inthat there is an incomplete sugar ring. The structural relationship ...

Google previewOxford Handbook of Clinical Pathology (2012)

by James Carton

Aciclovir is a guanosine analogue which is phosphorylated by viral thymidine kinase. Aciclovir triphosphate is incorporated into viral DNA and terminates chain replication. • Ganciclovir is related to acyclovir, but is more active against ...

Google preview320 Single Best Answer Questions for Final Year Medical Students (2016)

by Adam Ioannou

Aciclovir is a guanosine analogue antiviral medication used to treat herpes simplex infections. Aciclovir is incorporated into the viral DNA and prevents viral replication. 11. C Polycythaemia DLCO is a measure of the diffusion Respiratory ...

Google previewQuestions and Answers for Dental Nurses (2013)

by Carole Hollins

caries Aciclovir is a drug used ...

Google previewCrash Course: Cell Biology and Genetics (2013)

by Matthew Stubbs, Narin Suleyman

DNA polymerase inhibitors Aciclovir is an acyclic nucleoside analogue that acts as a chain terminator of herpesvirus DNA synthesis. It is a prodrug, converted to aciclovir monophosphate by a-herpesvirus encoded thymidine kinase.

Google previewInfectious Disease, eTextbook (2010)

Clinical Cases Uncovered by Hamish McKenzie, Robert Laing, Alexander Mackenzie, Pamela Molyneaux, Abhijit Bal

Aciclovir is a nucleoside analogue that ...

Google previewOral and Maxillofacial Surgery (2012)

by Lars Andersson, Karl-Erik Kahnberg, M. Anthony Pogrel

Aciclovir is an acyclic guanine nucleoside analog drug. Many generic forms of aciclovir are currently available. It is one of the most commonly used antiviral drugs and has been primarily used for the treatment of herpes simplex virus and ...

Google previewOphthalmic Surgery: Principles and Practice (2011)

by George L. Spaeth, Helen Danesh-Meyer, Ivan Goldberg, Anselm Kampik

Aciclovir is an anti-viral that is effective against the herpes family of viruses. It becomes activated in virus-infected cells by a virally encoded enzyme and is therefore non-toxic to uninfected cells. Ganciclovir is a nuceloside analog of aciclovir ...

Google previewABC of Dermatology (2014)

by Rachael Morris-Jones

Aciclovir is a well-established antiviral drug used in the treatment of HHV. It inhibits viral DNA polymerase and irreversibly inhibits viral DNA synthesis. The underlying diagnosis determines the dose and treatment duration. Primary genital ...

Google previewMolecular Medicine (2016)

An Introduction by Jens Kurreck, Cy Aaron Stein

Aciclovir is a prodrug that is initially administered in an inactive form and is then metabolized into the active species in the body. Following selective first phosphorylation by the viral thymidine kinase, cellular kinases further phosphorylate the ...

Google previewBlack’s Medical Dictionary (2017)

by Harvey Marcovitch

Aciclovir. An antiviral drug that inhibits DNA synthesis in cells infected by HERPES VIRUSES, although it does not eradicate them. It is only effective if started towards the onset of infection; uses include the treatment of herpes simplex ...

Google previewConcise Medical Dictionary (2015)

by Elizabeth Martin

aciclovir. (acyclovir) n. an antiviral drug that inhibits DNA synthesis in cells infected by *herpesviruses. Administered ...

Google previewBlack's Medical Dictionary (2005)

by Bloomsbury Publishing

Aciclovir is an antiviral drug that inhibits DNA synthesis in cells infected by HERPES VIRUSES, although it does not eradicate them. It is only effective if started at the onset of infection; uses include the systemic treatment of herpes simplex ...

Google previewConcise Dictionary of Pharmacological Agents (2012)

Properties and Synonyms by I.K. Morton, Judith M. Hall

aciclovir [BAN, INN, JAN] (acyclovir [USAN]: acyclovir sodium [USAN]; Zovirax") is a synthetic nucleoside analogue ANTIVIRAL. It can be used orally or topically to treat infection by the herpes viruses, and is valuable ...

Google previewDictionary of Obstetrics and Gynecology (1988)

by Christoph Zink

2–OH NH3 N Aciclovir (INN) adaptation, maternal: the physiological adaptation processes of the maternal organism during pregnancy. 1. organic changes (usually hormonally mediated): genitalia: increased size of the uterus ...

Google previewA Dictionary of Biomedicine (2010)

by John Lackie

See ACICLOVIR. 2. Ot—AIIllIlO— adipylcysteinylvaline, a precursor for isopenicillin synthesis. acyclovir See ACICLOVIR. acyl An organic radical or functional group derived from an organic acid. Common examples are formyl, acetyl, ...

Google previewA Dictionary of Dentistry (2010)

by Robert Ireland

acellular acesulfamepotassium acetate strip acetone acetylsalicylic acid ache acheilia achlorhydria achondroplasia aciclovir acid acidetch technique acidogenic acidogenic theory acidosis acidulated phosphate fluoride gel aciduric acinic cell ...

Google previewSaunders Comprehensive Veterinary Dictionary (2011)

by Virginia P. Studdert, Clive C. Gay, Douglas C. Blood

acyclovir, aciclovir [a-si'klo-vēr] a synthetic analog of guanosine which selectively interferes with viral DNA synthesis. Usedparenterally and topicallyasan antiviral agent, butmore effective compounds are available for treatment ofherpetic ...

Google previewHarty's Dental Dictionary (2007)

by Peter Heasman, Giles McCracken

aciclovir ( acyclovir) An antiviral drug of some use against the herpes viruses. The treatment is primarily symptomatic and only effective if started at the onset of the infection.

Google previewA Dictionary of Science (2017)

by Jonathan Law

acetyl coenzyme A acetylene acetylenes acetyl group acetylide achene Acheson process achiral achondrite achromatic lens aciclovir acid acid anhydrides acid– base balance acid–base indicator acid dissociation constant acid dye acid ...

Google previewDictionary of Veterinary Nursing (2007)

by Denis Richard Lane, Sue Guthrie, Sian Griffith

aciclovir An antiviral substance that inhibits theformation ofDNA andhas been used in animal herpes infections. acid Chemical substances with pH lower than 7 , ...

Google previewBlack's Veterinary Dictionary (2015)

Aciclovir may be used for ophthalmic infections by herpesviruses. Zidurodine alleviates clinical signs in cases of feline immunodeficiency virus (FIV). However, antiviral drugs have to be used with great care as the margin between an effective ...

Google previewPharmaceutical Manufacturing Encyclopedia, 3rd Edition (2013)

by William Andrew Publishing

ethyl ester Common Name: Aciclovir valinate; Valaciclovir; Valacyclovir Structural Formula: Chemical Abstracts Registry No.

Google previewThe Dictionary of Cell and Molecular Biology (2012)

by John M. Lackie

Aciclovir. (2) Alpha-aminoadipylcysteinylvaline, precursor for isopenicillin synthesis. ACV synthase Enzyme (alpha-aminoadipylcysteinyl- valine synthase, EC, 3770aa in Emericella nidulans) responsible for an early step in ...

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Scrabble value of A1C3I1C3L1O1V4I1R1

The value of this 9-letter word is 16 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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