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Active site

Definition of the noun active site

What does active site mean as a name of something?

noun

  1. the part of an enzyme or antibody where the chemical reaction occurs
    • lexical domain: Locations - nouns denoting spatial position
    • more generic words: site / situation = physical position in relation to the surroundings
    • part of: enzyme = any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions; antibody = any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response

Explanation

Active site: In biology, the active site is a small port in an enzyme where substrate molecules bind and undergo a chemical reaction. This chemical reaction occurs when a substrate collides with and slots into the active site of an enzyme. The active site is usually found in a 3-D groove or pocket of the enzyme, lined with amino acid residues. These residues are involved in recognition of the substrate. Residues that directly participate in the catalytic reaction mechanism are called active site residues. After an active site has been involved in a reaction, it can be used again. Many enzymes have deeply buried active sites, which can be accessed by a substrate via access channels.

  • also known as 活性位点

Printed dictionaries and other books with definitions for Active site

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Google previewConcise Dictionary of Biomedicine and Molecular Biology (2001)

by Pei-Show Juo

Active Site Region of an enzyme molecule at which the substrate binds and the catalytic event occurs (also called catalytic site). Active Site-Directed Irreversible Inhibitor An artificially designed inhibitor giving irreversible inhibition for a given ...

Google previewDictionary of Chemistry (2014)

by Andrew Hunt

active site It is possible to determine the activation energy for a reaction by measuring its rate over a range of temperatures and then using the Arrhenius equation. active site: the part of a catalyst that is responsible for its catalytic activity.

Google previewA Dictionary of Biology (2015)

by Elizabeth Martin, Robert Hine

A substance that—by binding to an *allosteric site on an enzyme—enables the active site of the enzyme to bind to the substrate. 3. Any compound that potentiates the activity of a drug or other foreign substance in the body. active immunity ...

Google previewDictionary of Biomedical Science (2002)

by Peter J. Gosling

active site (biochemistry) Part of an ENZYME that firstly specifically binds the SUBSTRATE(s) and secondly ...

Google previewEncyclopedia of toxicology (2005)

Dib-L] by Philip Wexler, Bruce D. Anderson

However, the strand-displacement activity was impaired, indicating that this activity of the ø29 DNA polymerase is located in the amino- terminal domain, somehow overlapping with the 3′–5′ exonuclease active site. Other amino acid ...

Google previewEncyclopedia of Optimization (2008)

by Christodoulos A. Floudas, Panos M. Pardalos

active set strategy see: Goldfarb-ldnani — active sets and interior point methods see: Successive quadratic programming: solution by — active site [92B05] (see: Genetic algorithms for protein structure prediction) active site [ 92B05] ...

Google previewA Dictionary of Science (2010)

by Elizabeth A. Martin

active site (active centre) 1. A site on the surface of a catalyst at which activity occurs. 2.

Google previewEncyclopedia of Molecular Pharmacology

by Stefan Offermanns

In this motif the two histidines are metal ligands while the glutamic acid is an >• active site residue. Glutamate carboxypeptidase binds two zinc ions via two histidines, an aspartic acid and two glutamic acids and in addition has two active site ...

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