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Header of Acyclovir


Definition of the noun Acyclovir

What does Acyclovir mean as a name of something?

noun - plural: acyclovirs

  1. An antiviral drug used in the treatment of genital herpes.


Acyclovir a.k.a. Aciclovir: A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses. After conversion in vivo to the active metabolite acyclovir triphosphate, acyclovir competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the thymidine kinase of HSV.

Printed dictionaries and other books with definitions for Acyclovir

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Google previewAntiviral Drug Development (2012)

A Multidisciplinary Approach by Erik De Clercq, Richard T. Walker

Acyclovir is an extremely poor substrate for cellular thymidine kinase which explains its high selectivity for the viral infected cell. Acyclovir...

Google previewBratton's Family Medicine Board Review (2014)

by Robert A. Baldor

Acyclovir is a purine compound used as an antiviral agent against the herpes virus. The medication is incorporated into the viral DNA and inhibits DNA polymerase, thus preventing replication of the ...

Google previewOxford Desk Reference: Critical Care (2008)

by Carl Waldmann, Neil Soni, Andrew Rhodes

Acyclovir a nucleoside analogue and requires intracellular activation to exert antiviral activity It is active against herpesviruses. Acyclovir is a preferred substrate for the viral ...

Google previewEncyclopedia of Health (2010)

Acyclovir is an antiviral drug that kills cells infected ...

Google previewCesarean Section (2012)

Guidelines for Appropriate Utilization by Bruce L. Flamm, Edward J. Quilligan

Acyclovir is a nucleoside analog whose selective activity inhibits the replication of HSV at concentrations as much as 3000 fold less than those that inhibit mammalian cellular functions. Because of its remarkable specificity for cells already ...

Google previewCutaneous Manifestations of HIV Disease (2012)

by Clay Cockerell, Antoanella Calame

Acyclovir is the prototypic antiherpetic agent and is effective against HSV- 1 and - 2, VZV, and somewhat against EBV.59 Acyclovir is a guanosine analog that is selectively phosphorylated by the herpes virus-encoded enzyme thymidine kinase ...

Google previewHIV and AIDS (2008)

by Doctorndtv.Com

Acyclovir is a drug often used for herpes-2 and helps in cutting down the period of symptomatic disease or episode. The main shedding of the virus ( infectiousness) is during the periodic symptomatic phases. However, in a significant ...

Google previewTextbook of Dermatology, Leprology & Venereology (2013)

by Devinder Mohan Thappa

Acyclovir is a synthetic guanosine analog, which is widely used for the treatment of herpes simplex virus and varicella zoster virus infections. Mode of action: Acyclovir, a prodrug, initially undergoes monophosphorylation by herpes ...

Google previewEquine Infectious Diseases (2013)

by Debra C. Sellon, Maureen Long

Nucleoside Analogs Acyclovir is an acyclic guanosine ...

Google previewTextbook of Ophthalmology (2011)

by HV Nema, Nitin Nema

Acyclovir is a drug of choice for the treatment of herpetic infection of eye, skin and genitals. It is more potent than IDU, TFT and Ara-A in herpetic infection of the cornea because it penetrates the intact corneal epithelium and stroma and ...

Google previewGenetic Variation in Drug Transporters in Ethnic Populations (2008)

by Cheryl D. Cropp

Acyclovir is an anionic, polar molecule with a ...

Google previewTextbook of Oral and Maxillofacial Surgery (2008)

by Neelima Anil Malik, Malik

Acyclovir (Cyclovir, Zovirax) Acyclovir is a guanosine analogue and a potent ...

Google previewBiochemistry and Molecular Biology of Antimicrobial Drug Action (2005)

by Trevor J. Franklin, George Alan Snow

Acyclovir is a prodrug that is first converted to the monophosphate derivative by thymidine kinase (TK) encoded in the viral genome, and subsequently to the inhibitory triphosphate by enzymes of the infected host cell. One relatively uncommon ...

Google previewPharmacology (2007)

by Gary C. Rosenfeld, David S. Loose

Acyclovir is a purine analogue that needs to be converted to nucleoside triphosphate for activity. b. Acyclovir requires viral thymidine kinase to be converted to monophosphate; it then uses cellular enzymes to be converted to a triphosphate ...

Google previewPediatric Critical Care Medicine (2006)

by Anthony D. Slonim, Murray M. Pollack

Nucleoside Analogs Acyclovir and Valacyclovir Acyclovir is an analog of 2'-deoxyguanosine.

Google previewEncyclopedia of Microbiology, Four-Volume Set (2000)

by Martin Alexander, Barry R. Bloom, David A. Hopwood, Roger Hull, Barbara H. Iglewski, Allen I. Laskin, Stephen G. Oliver, Moselio Schaechter, William C. Summers

Acyclovir and Valaciclovir Acyclovir has become the most widely prescribed and clinically effective antiviral drug available to date. Valaciclovir, the L-valine ester oral prodrug of ...

Google previewThe Encyclopedia of Skin and Skin Disorders, Third Edition (2009)

by Carol Turkington, Jeffrey S. Dover

acyclovir (Trade name: Zovirax) An antiviral drug introduced in 1982 used in treating the virus causing HERPES SIMPLEX INFECTION, SHINGLES, and CHICKEN POX. Acyclovir is available in topical or oral form. Severe cases ...

Google previewThe Encyclopedia of Blindness and Vision Impairment (2002)

by Jill Sardegna, Susan Shelly, Scott Steidl

Acyclovir is distinctive in that, unlike other antiviral medications, it attacks the viral cells only and disregards normal cells. Acyclovir is available in pill, cream, injection, or ointment form. It is commonly used to treat HERPES SIMPLEX type 1 and ...

Google previewEncyclopedia of the Neurological Sciences (2014)

Table 2 Antiviral agents and the nonretroviral viruses against which they are effective Antiviral agents Active against Acyclovir (Zovirax) Famcyclovir (Famvir) Amantadine (Symmetrel) Rimantadine (Flumadine) Ribavirin (Virazole) Valacyclovir ...

Google previewSexually Transmitted Disease: An Encyclopedia of Diseases, Prevention, Treatment, and Issues (2013)

An Encyclopedia of Diseases, Prevention, Treatment, and Issues by Jill Ann Grimes MD, Lori Apffel Smith MD, Kristyn Fagerberg MD

Acyclovir. (Zovirax). There are many antivirals used to treat sexually transmitted diseases (STDs). An- tiviral medications typically cannot eliminate viral infections (versus antibiotics, which can cure bacterial infections), but antivirals can ...

Google previewEncyclopedia of the Eye, Four-Volume Set (2010)

by Joseph Besharse, Reza Dana

andvaline and glycinebased dipeptide conjugateof acyclovir – valine–valine–acyclovir (VVACV)and glycine–valine–acyclovir ( GVACV) are shown inFigure5. VACV isfoundtobehydrolyzedprimarily by esterasesto ...

Google previewEncyclopedia of Sexually Transmitted Diseases (2004)

by Elaine A. Moore, Lisa Marie Moore

Some recommend acyclovir (400 mg twice daily) to try to prevent transmission, some recommend cesarean section and some recommend both.

Google previewThe Complete Encyclopedia of Medicine & Health (2006)

by J. P. Schadé

However, the antiviral medication acyclovir (Zovirax) actually stops the herpesvirus ...

Google previewEssential 18000 English-Norwegian Medical Words Dictionary (2015)

by Nam Nguyen

acyclovir (acycloguanosine). a nucleoside analog antiviral drug used to treat the symptoms of the genital form of herpes simplex virus infection. see also herpes simplex virus; nucleoside analog. acyclovir (Acycloguanosine). en antiviral ...

Google previewThe Dictionary of Virology (2009)

by Brian W.J. Mahy

They include acyclovir, bucyclovir, ganciclovir, penciclovir, and 2HM-HBG. de Clercq E (1995) Rev Med Virol 5, 149 acyclic nucleoside phosphonates A series of antiviral compounds active against a wide range of DNA viruses. They include ...

Google previewEncyclopedia of AIDS (1998)

A Social, Political, Cultural, and Scientific Record of the HIV Epidemic by Raymond A. Smith

Acyclovir (Zovirax) is approved for the treatment of HSV inital infections and reactivations. It is also used to prevent reactivations in high-risk patients such as people with HIV/AIDS. Acyclovir is not a cure for HSV; it only holds infection in check ...

Google previewDictionary of DNA and Genome Technology (2012)

by Paul Singleton

acyclovir(alternative spelling: aciclovir ) 9-(2-hydroxyethoxy- methyl)guanine: an antiviral agent active against a number ...

Google previewThe Encyclopedia of Infectious Diseases (2007)

by Carol Turkington, Bonnie Ashby

acyclovir ( Trade name: Zovirax) An antiviral drug prescribed for the treatment of herpes simplex, ...

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Scrabble value of A1C3Y4C3L1O1V4I1R1

The value of this 9-letter word is 19 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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