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Definition of the noun Acyclovir
What does Acyclovir mean as a name of something?
noun - plural: acyclovirs
- An antiviral drug used in the treatment of genital herpes.
- synonym: acycloguanosine
Acyclovir a.k.a. Aciclovir: A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses. After conversion in vivo to the active metabolite acyclovir triphosphate, acyclovir competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the thymidine kinase of HSV.
- read more about Aciclovir
Printed encyclopedias and other books with definitions for Acyclovir
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Understanding Viruses (2016)
by Teri Shors
Acyclovir is a guanosine nucleoside analog (FIGURE3-40A). The Active Form ACV-TP O ACV-MP ACV-DP O Cellular kinase Cellular kinase HSV-1DNA polymerase “freezes” = Chain termination DNA DNA Information from De Clercq, E. 2002 ...
by John A. Yagiela, Frank J. Dowd, Bart Johnson, Angelo Mariotti, Enid A. Neidle
Acyclovir is a product of research revolving around the synthesis of compounds designed to mimic substrates for adenosine...
Acyclovir is an analogue of guanosine, or deoxyguanosine, in which two carbon atoms are missing from the ribose ...
Antiviral Drug Development (2012)
A Multidisciplinary Approach by Erik De Clercq, Richard T. Walker
Acyclovir is an extremely poor substrate for cellular thymidine kinase which explains its high selectivity for the viral infected cell. Acyclovir...
by Robert A. Baldor
Acyclovir is a purine compound used as an antiviral agent against the herpes virus. The medication is incorporated into the viral DNA and inhibits DNA polymerase, thus preventing replication of the ...
Comprehensive Biomaterials (2015)
by Paul Ducheyne, Kevin Healy, Dietmar E. Hutmacher, David W. Grainger, C. James Kirkpatrick
Self-assembled nanoparticles from prodrugs Acyclovir is a nucleoside antiviral agent against herpes simplex virus (HSV) with low oral bioavailability, typically < 20%, and a short circulation half-life, t1/2 1⁄4 2.5 h.90 Jin et al. have synthesized a ...
Encyclopedia of Health (2010)
Acyclovir is an antiviral drug that kills cells infected ...
Cesarean Section (2012)
Guidelines for Appropriate Utilization by Bruce L. Flamm, Edward J. Quilligan
Acyclovir is a nucleoside analog whose selective activity inhibits the replication of HSV at concentrations as much as 3000 fold less than those that inhibit mammalian cellular functions. Because of its remarkable specificity for cells already ...
HIV and AIDS (2008)
Acyclovir is a drug often used for herpes-2 and helps in cutting down the period of symptomatic disease or episode. The main shedding of the virus ( infectiousness) is during the periodic symptomatic phases. However, in a significant ...
by Anita Gupta, Nina Singh-Radcliff
*Also exhibits activity against HIV; **Also active against adenovirus and HPV Acyclovir is an analogue of nucleoside 2'-deoxyguanosine; it is activated within • the virus via phosphorylation.
by Devinder Mohan Thappa
Acyclovir is a synthetic guanosine analog, which is widely used for the treatment of herpes simplex virus and varicella zoster virus infections. Mode of action: Acyclovir, a prodrug, initially undergoes monophosphorylation by herpes ...
by Clay Cockerell, Antoanella Calame
Acyclovir is the prototypic antiherpetic agent and is effective against HSV- 1 and - 2, VZV, and somewhat against EBV.59 Acyclovir is a guanosine analog that is selectively phosphorylated by the herpes virus-encoded enzyme thymidine kinase ...
Textbook of Ophthalmology (2011)
by HV Nema, Nitin Nema
Acyclovir is a drug of choice for the treatment of herpetic infection of eye, skin and genitals. It is more potent than IDU, TFT and Ara-A in herpetic infection of the cornea because it penetrates the intact corneal epithelium and stroma and ...
by Gary C. Rosenfeld, David S. Loose
Acyclovir is a purine analogue that needs to be converted to nucleoside triphosphate for activity. b. Acyclovir requires viral thymidine kinase to be converted to monophosphate; it then uses cellular enzymes to be converted to a triphosphate ...
by F S K Barar
Acyclovir (Zovirax) Acyclovir is a guanosine derivative, and has potent ...
Equine Infectious Diseases (2013)
by Debra C. Sellon, Maureen Long
Nucleoside Analogs Acyclovir is an acyclic guanosine ...
by James G. Marks Jr., Jeffrey J. Miller
Acyclovir is a synthetic acyclic purine nucleoside analog. Phosphorylation of acyclovir depends on HSVspecific thymidine kinase. This enzyme converts acyclovir to ...
by Bhushan Kumar, Somesh Gupta
Acyclovir is a white crystalline powder soluble in water.135 It is highly active against HSV-1, slightly less active against HSV-2 and approximately eightfold less active against the varicella zoster virus. It is also active against Epstein–Barr virus ...
by Anthony D. Slonim, Murray M. Pollack
Nucleoside Analogs Acyclovir and Valacyclovir Acyclovir is an analog of 2'-deoxyguanosine.
2-Volume Set by Robert J. Mason, V.Courtney Broaddus, Thomas R Martin, Talmadge E King Jr., Dean Schraufnagel, John F. Murray, Jay A. Nadel
Acyclovir is an effective treatment that results in prompt improvement.20 Varicellazoster virus has also ...
Diseases of the Fetus and Infant by Richard J. Martin, Avroy A. Fanaroff, Michele C. Walsh
Resistance to acyclovir is a concern and has been seen in mothers who have had multiple recurrences treated with suppressive acyclovir, mothers who have taken oral acyclovir for suppression in the later part of pregnancy, and even in a few ...
by Howard M. Fillit, Kenneth Rockwood, Kenneth Woodhouse
Acyclovir is a safe but variably efficacious agent, though famciclovir is also used. In one double-blind, randomized group study of 55 patients, it was found that.
Online dictionaries and encyclopedias with entries for Acyclovir
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Scrabble value of A1C3Y4C3L1O1V4I1R1
The value of this 9-letter word is 19 points, but it's not an accepted word in the Official Scrabble Players Dictionary.
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