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Acyclovir

Definition of the noun Acyclovir

What does Acyclovir mean as a name of something?

noun - plural: acyclovirs

  1. An antiviral drug used in the treatment of genital herpes.

Explanation

Acyclovir a.k.a. Aciclovir: A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses. After conversion in vivo to the active metabolite acyclovir triphosphate, acyclovir competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the thymidine kinase of HSV.

Printed encyclopedias and other books with definitions for Acyclovir

Click on a title to look inside that book (if available):

Google previewAntiviral Drug Development (2012)

A Multidisciplinary Approach by Erik De Clercq, Richard T. Walker

Acyclovir is an extremely poor substrate for cellular thymidine kinase which explains its high selectivity for the viral infected cell. Acyclovir...

Google previewPharmacology and Therapeutics for Dentistry (2010)

by John A. Yagiela, Frank J. Dowd, Bart Johnson, Angelo Mariotti, Enid A. Neidle

Acyclovir is a product of research revolving around the synthesis of compounds designed to mimic substrates for adenosine...

Acyclovir is an analogue of guanosine, or deoxyguanosine, in which two carbon atoms are missing from the ribose ...

Google previewUnderstanding Viruses (2016)

by Teri Shors

Acyclovir is a guanosine nucleoside analog (FIGURE3-40A). The Active Form ACV-TP O ACV-MP ACV-DP O Cellular kinase Cellular kinase HSV-1DNA polymerase “freezes” = Chain termination DNA DNA Information from De Clercq, E. 2002 ...

Google previewSexually Transmitted Infections (2014)

by Bhushan Kumar, Somesh Gupta

Acyclovir is a white crystalline powder soluble in water.135 It is highly active against HSV-1, slightly less active against HSV-2 and approximately eightfold less active against the varicella zoster virus. It is also active against Epstein–Barr virus ...

Google previewComprehensive Biomaterials (2015)

by Paul Ducheyne, Kevin Healy, Dietmar E. Hutmacher, David W. Grainger, C. James Kirkpatrick

Self-assembled nanoparticles from prodrugs Acyclovir is a nucleoside antiviral agent against herpes simplex virus (HSV) with low oral bioavailability, typically < 20%, and a short circulation half-life, t1/2 1⁄4 2.5 h.90 Jin et al. have synthesized a ...

Google previewEncyclopedia of Health (2010)

Acyclovir is an antiviral drug that kills cells infected ...

Google previewLookingbill and Marks' Principles of Dermatology (2013)

by James G. Marks Jr., Jeffrey J. Miller

Acyclovir is a synthetic acyclic purine nucleoside analog. Phosphorylation of acyclovir depends on HSVspecific thymidine kinase. This enzyme converts acyclovir to ...

Google previewFanaroff and Martin's Neonatal-Perinatal Medicine (2014)

Diseases of the Fetus and Infant by Richard J. Martin, Avroy A. Fanaroff, Michele C. Walsh

Resistance to acyclovir is a concern and has been seen in mothers who have had multiple recurrences treated with suppressive acyclovir, mothers who have taken oral acyclovir for suppression in the later part of pregnancy, and even in a few ...

Google previewCesarean Section (2012)

Guidelines for Appropriate Utilization by Bruce L. Flamm, Edward J. Quilligan

Acyclovir is a nucleoside analog whose selective activity inhibits the replication of HSV at concentrations as much as 3000 fold less than those that inhibit mammalian cellular functions. Because of its remarkable specificity for cells already ...

Google previewCutaneous Manifestations of HIV Disease (2012)

by Clay Cockerell, Antoanella Calame

Acyclovir is the prototypic antiherpetic agent and is effective against HSV- 1 and - 2, VZV, and somewhat against EBV.59 Acyclovir is a guanosine analog that is selectively phosphorylated by the herpes virus-encoded enzyme thymidine kinase ...

Google previewEssentials of Pharmacotherapeutics (2000)

by F S K Barar

Acyclovir (Zovirax) Acyclovir is a guanosine derivative, and has potent ...

Google previewHIV and AIDS (2008)

by Doctorndtv.Com

Acyclovir is a drug often used for herpes-2 and helps in cutting down the period of symptomatic disease or episode. The main shedding of the virus ( infectiousness) is during the periodic symptomatic phases. However, in a significant ...

Google previewPharmacology in Anesthesia Practice (2013)

by Anita Gupta, Nina Singh-Radcliff

*Also exhibits activity against HIV; **Also active against adenovirus and HPV Acyclovir is an analogue of nucleoside 2'-deoxyguanosine; it is activated within • the virus via phosphorylation.

Google previewTextbook of Dermatology, Leprology & Venereology (2013)

by Devinder Mohan Thappa

Acyclovir is a synthetic guanosine analog, which is widely used for the treatment of herpes simplex virus and varicella zoster virus infections. Mode of action: Acyclovir, a prodrug, initially undergoes monophosphorylation by herpes ...

Google previewEquine Infectious Diseases (2013)

by Debra C. Sellon, Maureen Long

Nucleoside Analogs Acyclovir is an acyclic guanosine ...

Google previewTextbook of Ophthalmology (2011)

by HV Nema, Nitin Nema

Acyclovir is a drug of choice for the treatment of herpetic infection of eye, skin and genitals. It is more potent than IDU, TFT and Ara-A in herpetic infection of the cornea because it penetrates the intact corneal epithelium and stroma and ...

Google previewGenetic Variation in Drug Transporters in Ethnic Populations (2008)

Acyclovir is an anionic, polar molecule with a ...

Google previewHigh Risk Pregnancy (2010)

Management Options - Expert Consult by David K. James, Philip J. Steer, Carl P. Weiner, Bernard Gonik

infected newborns suggests that VariZIG in conjunction with intravenous acyclovir is a more effective prevention strategy than VariZIG alone.64 TABLE 29 –3 Evidence Quality and Prenatal If mother exposed to VZV, check immunity status.

Google previewTextbook of Oral and Maxillofacial Surgery (2008)

by Neelima Anil Malik, Malik

Acyclovir (Cyclovir, Zovirax) Acyclovir is a guanosine analogue and a potent ...

Google previewPharmacology (2007)

by Gary C. Rosenfeld, David S. Loose

Acyclovir is a purine analogue that needs to be converted to nucleoside triphosphate for activity. b. Acyclovir requires viral thymidine kinase to be converted to monophosphate; it then uses cellular enzymes to be converted to a triphosphate ...

Google previewBrocklehurst's Textbook of Geriatric Medicine and Gerontology (2010)

by Howard M. Fillit, Kenneth Rockwood, Kenneth Woodhouse

Acyclovir is a safe but variably efficacious agent, though famciclovir is also used. In one double-blind, randomized group study of 55 patients, it was found that.

Google previewMurray and Nadel's Textbook of Respiratory Medicine (2010)

2-Volume Set by Robert J. Mason, V.Courtney Broaddus, Thomas R Martin, Talmadge E King Jr., Dean Schraufnagel, John F. Murray, Jay A. Nadel

Acyclovir is an effective treatment that results in prompt improvement.20 Varicellazoster virus has also ...

Google previewPediatric Critical Care Medicine (2006)

by Anthony D. Slonim, Murray M. Pollack

Nucleoside Analogs Acyclovir and Valacyclovir Acyclovir is an analog of 2'-deoxyguanosine.

Online dictionaries and encyclopedias with entries for Acyclovir

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Scrabble value of A1C3Y4C3L1O1V4I1R1

The value of this 9-letter word is 19 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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