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Header of Afterload


Definition of the noun Afterload

What does Afterload mean as a name of something?


  1. [physiology] The load on a working muscle from a constant opposing force


Afterload is the tension or stress developed in the wall of the left ventricle during ejection. In other words, it is the end load against which the heart contracts to eject blood. Afterload is readily broken into components: it is the aortic pressure the left ventricular muscle must overcome to eject blood. The greater the aortic/pulmonary pressure, the greater the after load on the left/right ventricle, respectively. Following Laplace's law, the tension upon the muscle fibers in the heart wall is the pressure within the ventricle multiplied by the volume within the ventricle, divided by the wall thickness. Therefore, when comparing a normal heart to a heart with a dilated left ventricle, if the aortic pressure is the same in both hearts, the dilated heart must create a greater tension to overcome the same aortic pressure to eject blood because it has a larger internal radius and volume. Thus, the dilated heart has a greater total load on the myocytes, i.e., has a higher afterload. Conversely, a hypertrophied left ventricle has a lower afterload. When contractility becomes impaired and the ventricle dilates, the afterload rises and limits output.

Printed dictionaries and other books with definitions for Afterload

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Google previewArterial Hypertension (2012)

Pathogenesis, Diagnosis, and Therapy by J. Rosenthal

Afterload is a term initially used in isolated muscle experiments. In the intact heart , afterload refers to systolic myocardial wall tension, which is determined by intraventricular pressure and ventricular size. When preload and contractility are held ...

Google previewCardiology (2012)

An Illustrated Textbook by Kanu Chatterjee, Mark Anderson, Donald Heistad

Afterload is a product of LV cavity size (La Place relationship) and is inversely related to wall thickness or hypertrophy. In clinical practice, systemic vascular resistance (SVR) is frequently calculated [SVR : (mean arterial pressure — CVP) x ...

Google previewGerioperative Nursing Care (2011)

Principles and Practices of Surgical Care for the Older Adult by Dr. Raelene V. Shippee-Rice, PhD, RN, Dr. Susan Fetzer, PhD, RN, MBA, Jennifer V. Long, CRNA, CRNP, MS, Alexandra Armitage, MS, CNL, APRN

Afterload refers to the resistance that the ventricular contraction must overcome to eject stroke volume. Resistance is produced by the weight of the blood, the flexibility of the aortic valve, and the diastolic pressure in the aorta. When there are ...

Google previewAcute Coronary Care 1986 (2012)

by Robert M. Califf, G.S. Wagner

The term afterload refers to the hydraulic forces (impedance) opposing the left wentricle as it ejects blood. The determinants of impedance in the human circulation are complex, difficult to measure and require sophisticated analysis. Therefore ...

Google previewManual of Critical Care Nursing (2010)

Nursing Interventions and Collaborative Management by Marianne Saunorus Baird, Susan Bethel

Afterload refers to the pressure or force which must be generated within the right and left ventricles/ventricular myocardium during systole to overcome the vascular resistance to ejection. The pressures created by the blood volume ...

Google previewHypertension: A Companion to Braunwald's Heart Disease (2012)

by Henry R. Black, William Elliott

Increased aortic pulsatile afterload is a major factor in the development of left ventricular hypertrophy (LVH) with increased coronary blood flow requirements. In addition, increased turbulent flow leads to endothelial dysfunction with a greater ...

Google previewACCCN's Critical Care Nursing (2011)

by Doug Elliott, Leanne Aitken, Wendy Chaboyer

Afterload is a major determinant of blood pressure, ...

Google previewFaust's Anesthesiology Review E-Book (2014)

Expert Consult by Michael J. Murray, Steven H. Rose, Denise J. Wedel, C. Thomas Wass, Barry A Harrison, Jeff T Mueller

Reducing afterload is an important goal in managing congestive heart failure. Contractility Contractility refers to the intrinsic ability of the myocardium to generate force at given end-diastolic fiber length and is closely related to the availability of ...

Google previewEquine Anesthesia (2008)

Monitoring and Emergency Therapy by William W. Muir III, John A. E. Hubbell

Ventricular afterload is a term used to describe the forces that resist the ejection of blood into the aorta and is closely related to the tension (or stress) in the ventricular wall during systole. Afterload can be thought of in terms of vascular ...

Google previewBraunwald's Heart Disease (2011)

A Textbook of Cardiovascular Medicine by Robert O. Bonow, Douglas L. Mann, Douglas P. Zipes, Peter Libby

Increased afterload means that an increased intraventricular pressure has to be generated first to open the aortic valve and then during the ejection phase.These increases will be translated into an increased myocardial wall stress, which can ...

Google previewEncyclopedia of International Sports Studies: F-O (2006)

by Roger Bartlett, Chris Gratton, Christer Rolf

One of the most important clinical features of the systolic murmur of HCM is that it changes as the dynamic pressure gradient changes in response to increased myocardial contractility, decreased preload, and decreased afterload. Helpful ...

Google previewMosby's Dental Dictionary (2013)

by Elsevier, Mosby

Isotrate, Dilatrate-SR, Isordil; drug class: nitrate antianginal; action: generates nitric oxide, which relaxes vascular smooth muscle, thereby decreasing preload/ afterload. This is responsible for decreasing left ventricular end-diastolic pressure ...

Google previewEncyclopedia of Heart Diseases (2005)

by M. Gabriel Khan

Prevention and Management GLOSSARY afterload arterial impedance, restriction to blood flow delivered from the left ventricle; force against which the myocardium contracts in systole; a major determinant of wall stress. arrhythmia general ...

Google previewEncyclopedia of Nursing Research, Third Edition (2011)

by Joyce J. Fitzpatrick, PhD, MBA, RN, FAAN, Meredith Kazer, PhD, APRN, A/GNP-BC

afterload, and contractility to improve overall cardiac output and tissue perfusion. Nurses must be trained with the requisite knowledge and skills to work with these invasive devices and hemodynamic monitoring remains a fundamental ...

Google previewChurchill Livingstone Medical Dictionary (2008)

by Chris Brooker

afterload n the pressure of blood in aorta and vessel constriction that forms the resistance or load that ...

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Video about Afterload

Afterload Meaning

Video shows what afterload means. The load on a working muscle from a constant opposing force. Afterload Meaning. How to pronounce, definition audio ...

Scrabble value of A1F4T1E1R1L1O1A1D2

The value of this 9-letter word is 13 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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