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Definition of the noun alkylating agent
What does alkylating agent mean as a name of something?
- an antineoplastic drug used to treat some forms of cancer
- Alkylating agent are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumour growth by cross-linking guanine nucleobase in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. These drugs act nonspecifically. Some of them require conversion into active substances in vivo.
- Alkylating Agent: Agents that replace hydrogen atom in biologically active molecules with alky radical, hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cell growth.
Printed dictionaries and other books with definitions for Alkylating agent
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by Stefan Offermanns, Walter Rosenthal
Alkylating agent Classic (nitrogen mustards) Mechloretamine (nitrogen mustard) Cyclophosphamide Ifosfamide Chlorambucil (leukeran) Melphalan (alkeran) Alkyl sulfonates Busulfan Nitrosoureas Carmustine Lomustine Streptozocin ...
by Robert Alan Lewis
alkylating agent. any substance that is able to form covalent bonds and attach alkyl groups (e.g., methyl, ethyl) to nitrogen and oxygen atoms ...
by Nam Nguyen
သာသနာျပုပုဂ္ဂိုလံမ့ာဵ acidosis ။ 1434 alkylate to treat with an alkylating agent. alkylate တစံဤီဵ alkylating ေအဵဂ့ငံဴဴ္ငံဴအတူကုသရနံ။ 1435 alkylating agent an organic compound ...
alkylating agent /al'kila'ting/, any substance that contains an alkyl radical and is capable of replacing a free hydrogen atom in an organic compound, or one that acts by a similar mechanism.
by Nam Nguyen
alkylate to treat with an alkylating alkylate sa paggamot sa isang alkylating agent. agent. 1435 alkylating agent an organic ...
Mosby's Dictionary of Medicine, Nursing and Health Professions - Australian & New Zealand Edition (2009)
by Peter Harris, Sue Nagy, Nicholas Vardaxis
alkylating agent /al'kila'ting/ (in medicine) a substance that ...
Dictionary of Rheumatology (2009)
by Jozef Rovenský, Juraj Payer
-tetrahydro-2H-1,3,2- oxazaphospho- rin-2-amino-2-oxide, an alkylating agent that after binding to DNA changes ...
Encyclopedia of Toxicology (2005)
by Bruce Anderson, Ann de Peyster, Shayne C. Gad, P.J. Bert Hakkinen, Michael Kamrin, Betty Locey, Harihara M. Mehendale, Carey Pope, Lee Shugart
• S YNONYMS: NnitrosoNmethylurea; 1Methyl1 nitrosourea; MNU; NNitrosoNmethylcarbamide; Nitrosomethylurea; NMethylNnitrosourea • C HEMICAL/P HARMACEUTICAL /O THER C LASS : Alkylating agent; DNA alkylating agent ...
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