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Alkylating agent

Alkylating agent is a tautogram (all words start with the same letter). View more tautograms!

Definition of the noun alkylating agent

What does alkylating agent mean as a name of something?

noun

  1. an antineoplastic drug used to treat some forms of cancer

Explanation

  1. Alkylating agent are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumour growth by cross-linking guanine nucleobase in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. These drugs act nonspecifically. Some of them require conversion into active substances in vivo.
  2. Alkylating Agent: Agents that replace hydrogen atom in biologically active molecules with alky radical, hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cell growth.

Printed dictionaries and other books with definitions for Alkylating agent

Click on a title to look inside that book (if available):

Google previewEncyclopedia of Molecular Pharmacology

by Stefan Offermanns

Alkylating agent Classic (nitrogen mustards) Mechloretamine (nitrogen mustard) Cyclophosphamide Ifosfamide Chlorambucil (leukeran) Melphalan (alkeran) Alkyl sulfonates Busulfan Nitrosoureas Carmustine Lomustine Streptozocin ...

Google previewLewis' Dictionary of Toxicology (1998)

by Robert Alan Lewis

alkylating agent. any substance that is able to form covalent bonds and attach alkyl groups (e.g., methyl, ethyl) to nitrogen and oxygen atoms ...

Google previewEncyclopedia of Applied Plant Sciences (2016)

an alkylating agent used very often in Arabidopsis thaliana mutagenesis, generates mostly CG / T-A transitions. The alkylating agents applied most frequently in plant mutagenesis are presented in Table 2.

Google previewHawley's Condensed Chemical Dictionary (2016)

by Michael D. Larrañaga, Richard J. Lewis, Sr., Robert A. Lewis

Use: Alkylating agent. sec-butyl bromide. (2-bromobutane). CAS: 78-76-2. CH3 CHBrCH2CH3. Properties: Clear, colorless liquid; pleasant ...

Google previewConcise Dictionary of Modern Medicine (2010)

by Joseph Segen

See Alkylating agent, Antidiabetic agent, Antimitotic agent, Antineoplastic agent, Antiplatelet agent, Antipsychotic agent, Chemotherapeutic agent, Depolarizing agent, Inotropic agent, Keratolytic agent, Negative inotropic agent, ...

Google previewThe SAGE Encyclopedia of Cancer and Society (2015)

by Graham A. Colditz

For instance, COPP— cyclophosphamide (a nitrogen mustard alkylating agent), Oncovin (the mitotic inhibitor vincristine), procarbazine (an antineoplastic alkylating agent), and prednisone (a corticosteroid)—is used to treat Hodgkin's ...

Google previewMosby's Pocket Dictionary of Medicine, Nursing & Health Professions - E-Book (2013)

by Mosby

alkylating agent /al'kila'ting/, any substance that contains an alkyl radical and is capable of replacing a free hydrogen atom in an organic compound, or one that acts by a similar mechanism.

Google previewMosby's Dictionary of Medicine, Nursing and Health Professions - Australian & New Zealand Edition (2014)

by Peter Harris, Sue Nagy, Nicholas Vardaxis

-alis alkylating agent -alis, suffix meaning 'pertaining to' something specified. aliskirin, the first antihypertensive agent directly targeting renin to be approved by the )DA (in the United States). Other approved antihypertensive drugs that act on ...

Google previewDictionary of Rheumatology (2009)

by Jozef Rovenský, Juraj Payer

-tetrahydro-2H-1,3,2- oxazaphospho- rin-2-amino-2-oxide, an alkylating agent that after binding to DNA changes ...

Google previewEncyclopedia of Toxicology (2005)

by Bruce Anderson, Ann de Peyster, Shayne C. Gad, P.J. Bert Hakkinen, Michael Kamrin, Betty Locey, Harihara M. Mehendale, Carey Pope, Lee Shugart

• S YNONYMS: NnitrosoNmethylurea; 1Methyl1 nitrosourea; MNU; NNitrosoNmethylcarbamide; Nitrosomethylurea; NMethylNnitrosourea • C HEMICAL/P HARMACEUTICAL /O THER C LASS : Alkylating agent; DNA alkylating agent ...

Google previewEncyclopedia of Global Health (2008)

by Yawei Zhang

Mitomycin is an antibiotic alkylating agent to cross-link DNA and attack hypoxic tumor stem cells. Side effects include nausea and vomiting and se- vere myelosuppression, bone marrow suppression, potential renal toxicity and interstitial ...

Google previewCRC Dictionary of Agricultural Sciences (2001)

by Robert Alan Lewis

alkylating agent, any substance capable of forming covalent bonds and attaching alkyl groups (e.g., methyl, ethyl) to nitrogen and oxygen atoms of macromole- cules such as the DNA bases. Such agents ...

Google previewMosby's Medical Dictionary (2016)

by Mosby

alkylating agent /al′′kilā′ting/, any substance that contains an alkyl radical and is capable of replacing a free hydrogen atom in an organic compound ...

Google previewDictionary of Inorganic Compounds (1992)

by Jane E. Macintyre

Alkylating agent. Colourless volatile liq. with powerful odour. Insol. H2O; sol. many org. solvs. Bp 78°. O-Propyl.

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