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Allopurinol

Definition of the noun Allopurinol

What does Allopurinol mean as a name of something?

noun - plural: allopurinols

  1. A drug used primarily to treat hyperuricemia and its complications.

Explanation

Allopurinol: A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies.

  • also known as 알로퓨리놀, แอลโลพูรินอล, 别嘌醇

Printed books with definitions for Allopurinol

Click on a title to look inside that book (if available):

Google previewBiomarkers in Drug Hypersensitivity (2017)

by José A. G. Agúndez, Silvia Selinski, Emanuela Corsini, Klaus Golka, Elena García-Martín

Allopurinol is a commonly prescribed medication that has been used to inhibit xanthine oxidase in patients with gouty arthritis, hyperuricemia, and in cancer patients undergoing chemotherapy (Lam et al., 2013; Min et al., 2015). In Thailand ...

Google previewAdvanced Assessment, Interpreting Findings and Formulating Differential Diagnoses (2016)

Medicine, Medicine by CTI Reviews

Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. Mechanism of action Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally ...

Google previewMedical-Surgical Nursing, Volume 1 and (2016)

by CTI Reviews

Allopurinol: Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronicgout. Mechanismofaction Allopurinol is a purine analog; it is a structural isomer of hypoxanthine ...

Google previewHead and Neck Cancer (2016)

by CTI Reviews

Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. Mechanism of action Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally ...

Google previewMerritts Neurology (2016)

by CTI Reviews

Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. Allopurinol is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an ...

Google previewClinical Handbook of Psychotropic Drugs (2016)

Medicine, Medicine by CTI Reviews

Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. Allopurinol is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an ...

Google previewNutrition and Diagnosis-Related Care (2016)

by CTI Reviews

Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. Allopurinol is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an ...

Google previewHarrison's Neurology in Clinical Medicine (2016)

Medicine, Neurology by CTI Reviews

Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. Allopurinol is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an ...

Google previewThe Molecular Basis of Cancer (2012)

by Peter B. Farmer, John M. Walker

Allopurinol is a drug that inhibits xanthine oxidase, an enzyme that converts hypoxanthine into xanthine and xanthine into uric acid. Uric acid is sparingly soluble in urine and can precipitate in the distal renal tubules causing damage to the ...

Google previewAdvances in Enzymology and Related Areas of Molecular Biology (2009)

by Alton Meister

Allopurinol is a pyrazolopyrimidine and so does not have an oxidizable C-8 locus . On the other hand, in analogy to hypoxanthine, it can be oxidized at C-2 and is converted by Xanthine oxidase to the 2-oxo product alloxanthine. Release of ...

Google previewAdvances and Updates in Internal Medicine, An Issue of Veterinary Clinics: Exotic Animal Practice (2010)

by Kemba Marshall

Allopurinol is a competitive xanthine oxidase inhibitor that blocks the metabolic pathways from hypoxanthine via xanthine to uric acid, thus decreasing uric acid production.9,63 Allopurinol must be used with caution in birds of prey, because ...

Google previewEssentials of Organic Chemistry (2013)

For Students of Pharmacy, Medicinal Chemistry and Biological Chemistry by Paul M. Dewick

The hypoxanthine analogue allopurinol is a drug that is used for this purpose. Allopurinol resembles hypoxanthine, though it contains a pyrazole ring rather than an imidazole ring. Allopurinol is oxidized by the enzyme to alloxanthine.

Google previewClinical Pharmacy and Therapeutics (2011)

by Roger Walker

Allopurinol is an inhibitor of xanthine oxidase and will lead to the accumulation of mercaptopurine which ...

Google previewHandbook of ICU Therapy (2014)

by John Fuller, Jeff Granton, Ian McConachie

Allopurinol is a hypoxanthine analog that competitively inhibits xanthine oxidase and blocks the conversion of the metabolism of ...

Google previewSmall Animal Therapeutics (2013)

by R. J. Martin

Allopurinol acts to reduce the plasma uric acid concentration and the urinary output of the urates by inhibiting an enzyme ( xanthine oxidase). Allopurinol is a competitive antagonist of xanthine oxidase and leads ...

Google previewThe Top 100 Drugs (2014)

Clinical Pharmacology and Practical Prescribing by Andrew Hitchings, Dagan Lonsdale, Daniel Burrage, Emma Baker

Allopurinol is a xanthine oxidase inhibitor. Xanthine oxidase metabolises xanthine (produced from purines) to uric acid. Inhibition of xanthine oxidase lowers plasma uric acid concentrations and reduces precipitation of uric acid in the joints or ...

Google previewClinical Light Damage to the Eye (2012)

by David Miller

Allopurinol is a commonly used antihyperuricemic agent in treating gout. Scattered reports have appeared regarding the possible relationship between the development of lens opacities in relatively young patients (second to fourth decade) ...

Google previewPharmacology and Therapeutics for Dentistry (2010)

by John A. Yagiela, Frank J. Dowd, Bart Johnson, Angelo Mariotti, Enid A. Neidle

Also, although allopurinol is a competitive inhibitor, alloxanthine is a noncompetitive inhibitor of xanthine oxidase, with a higher potency than allopurinol. Xanthine oxidase catalyzes the oxidation of hypoxanthine to xanthine and then to uric ...

Google previewPhacoemulsification, Fourth Edition (2011)

by Amar Agarwal, Athiya Agarwal, Soosan Jacob

A/opurino/ Allopurinol is an antihyperuricemic drug widely used for the treatment of hyperuricemia and chronic gout. It inhibits the terminal step in uric acid synthesis, which results in a reduction of uric acid concentrations in both serum and ...

Google previewInternal Medicine (2012)

An Intensive Review by Ajay K. Singh, Joseph Loscalzo

Allopurinol is the standard treatment for both the prevention and treatment of hyperuricemia. Allopurinol is an inhibitor of xanthine oxidase and is extremely well tolerated. The most common adverse reaction is an erythematous skin rash due to ...

Google previewThe Brigham Intensive Review of Internal Medicine (2014)

by Ajay K. Singh, Joseph Loscalzo

Allopurinol is the standard treatment for both the prevention and treatment of hyperuricemia. Allopurinol is an inhibitor of xanthine oxidase and is extremely well tolerated. The most common adverse reaction is an erythematous skin rash due to ...

Google previewFanaroff and Martin's Neonatal-Perinatal Medicine (2010)

Diseases of the Fetus and Infant by Richard J. Martin, Avroy A. Fanaroff, Michele C. Walsh

Allopurinol is an inhibitor of xanthine oxidase and has free radical scavenging action, but in a study involving 32 TABLE 40–8 ...

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Video about Allopurinol

Allopurinol Meaning

Video shows what allopurinol means. A drug used primarily to treat hyperuricemia and its complications.. Allopurinol Meaning. How to pronounce, definition ...

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Scrabble value of A1L1L1O1P3U1R1I1N1O1L1

The value of this 11-letter word is 13 points. It is included in the first and second editions of the Official Scrabble Players Dictionary.

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