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Definition of the noun Bioactivation

What does Bioactivation mean as a name of something?


  1. [biology] The metabolic activation of xenobiotic compounds into reactive, toxic compounds

Specialised definition of the noun Bioactivation

Glossary of pesticide

transformation of a pesticide within an organism into a more biochemically active metabolite

Printed dictionaries and other books with definitions for Bioactivation

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Google previewOptimizing the "Drug-Like" Properties of Leads in Drug Discovery (2007)

by Ronald Borchardt, Edward Kerns, Michael Hageman, Dhrien Thakker, James Stevens

Avoidance of “toxicophores” or chemical structures that are likely to undergo bioactivation is a logical initial approach to lead optimization. A number of readily recognizable chemical structures have been associated with idiosyncratic reactions ...

Google previewPharmaceutical Industry Practices on Genotoxic Impurities (2014)

by Heewon Lee

are listed here Metabolic bioactivation is an inherent part of the Cramer classification as many of these class III structures undergo metabolic bioactivation to form potentially toxic chemical entities: ...

Google previewSupplementary Mutagenicity Tests (1993)

UKEMS Recommended Procedures by David J. Kirkland, Margaret Fox

Exogenous activation system Bioactivation is a pre-requisite for ...

Google previewGeneral and Molecular Pharmacology (2015)

Principles of Drug Action by Francesco Clementi, Guido Fumagalli

Bioactivation is a metabolic process that increases the toxicity of the substance through the formation of unstable intermediates or metabolites with highly reactive chemical bonds capable of reacting with organic macromolecules. In particular ...

Google previewMolecular Biology of the Toxic Response (1998)

by Alvaro Puga, Kendall Wallace

Because P450-mediated bioactivation is an initial and obligatory step in chemical carcinogenesis, the interindividual variation in metabolic activity of P450s may influence subsequent steps, including dotoxification by phase IIenzymes and the ...

Google previewEncyclopedia of Toxicology (2005)

by Bruce Anderson, Ann de Peyster, Shayne C. Gad, P.J. Bert Hakkinen, Michael Kamrin, Betty Locey, Harihara M. Mehendale, Carey Pope, Lee Shugart

bioactivation of carcinogens pertains only to inhibition of chemicalinduced carcinogenesis.

Google previewEncyclopedia of Dietary Supplements (Print) (2004)

by Paul M. Coates, M. Coates Paul, Marc Blackman, Marc R. Blackman, Gordon M. Cragg, Mark Levine, Jeffrey D. White, Joel Moss, Mark A. Levine

The anticancer benefits attributed to garlic are also associated with suppressed nitrosamine bioactivation. Evidence from multiple sources points to the effectiveness of garlic to block DNA alkylation, an initial step in nitrosamine carcinogenesis.

Google previewA Dictionary of Chemistry (2016)

by Richard Rennie, Jonathan Law

bioactivation. A metabolic process in which a product that is chemically reactive is produced from a relatively inactive precursor. biochemical. fuel. cell. A system that exploits biological reactions for the conversion of biomass (chemical energy) ...

Google previewThe Facts on File Dictionary of Environmental Science (2007)

by Bruce C. Wyman, L. Harold Stevenson

bioactivation likely to be bioaccumulated are not readily decomposed in either the environment or an organism and are likely to be stored in the fatty tissue. Bioaccumulation is also the progressive increase in the amount of a chemical in an ...

Google previewThe Dictionary of Substances and their Effects (DOSE) (2007)

by S D Gangolli

Other effects Any other adverse effects Nephrotoxicity may be caused by intrarenal bioactivation of the reduced glutathione-conjugate (3). Legislation Included in Schedule 4 (Release into Air: Prescribed Substances) Statutory Instrument ...

Google previewElsevier's Dictionary of Vitamins and Pharmacochemistry (2006)

by Henry Philippsborn

(Pharmaceutical chemistry; a medicamentous substance which needs metabolic bioactivation for turning active.) d medikamentöses Biovorprodukt n; medikamentöser Biovorläufer m f bioprécurseur m médicamenteux p bioprecursor m ...

Google previewEncyclopedia of Parasitology: A-M (2008)

by Heinz Mehlhorn, Horst Aspöck

regioisomer isoquine does not show any bioactivation, but the in vitro antimalarial activity is maintained. Isoquine seems to be an interesting 4-aminoquinoline for further development as antimalarial drug, not only ...

Google previewA Dictionary of Biomedicine (2010)

by John Lackie

bioactivation The conversion of a *xenobiotic substance to a more toxic or active derivative within the body. bioassay Any assay that involves using ...

Google previewThe Dictionary of Substances and Their Effects: C (1999)

by S. Gangolli

Phospholipase A2 activation may be part of the chain of causality leading from initial bioactivation to ultimate cell death in rat hepatocytes (38). Studies indicate that enzyme induction and toxicokinetics resulting from the oral administration of ...

Google previewEncyclopedia of Neuroscience (2009)

Volume One by Larry R. Squire

The mitochondrial ferrous iron catalyzes the bioactivation of protoxins (e.g., catechols, 1-methyl-4- phenyl-1,2 ...

Google previewThe Encyclopedia of Vitamin E (2007)

by Victor R. Preedy, Ronald Ross Watson

anthracene bioactivation in mammary tissue.

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Video about Bioactivation

Bioactivation Meaning

Video shows what bioactivation means. The metabolic activation of xenobiotic compounds into reactive, toxic compounds. Bioactivation Meaning. How to ...

Scrabble value of B3I1O1A1C3T1I1V4A1T1I1O1N1

The value of this 13-letter word is 20 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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