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Definition of the noun Electrotransfer
What does Electrotransfer mean as a name of something?
- [biology, genetics] the use of electroporation to transfer genetic material into cells
Printed dictionaries and other books with definitions for Electrotransfer
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MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia by Tomaz Jarm, Peter Kramar, Anze Zupanic
Abstract— Gene electrotransfer is a promising nonviral method for transferring genes into the cells. The method is based on electroporation and it has been proven to be successful in both in vivo and in vitro conditions. This phenomenon occurs when cells are exposed to electric field established by high and low voltage pulses. The first high voltage pulse results in a high level of cell permeabilization (permeabilization pulse), while the second low voltage pulse provides a driving force ...
by Ales Iglic
Gene electrotransfer is a very promising method for use in gene therapy and the first clinical trials were successfully concluded [4–6]. Another promising field for gene electrotransfer is genetic vaccination. While gene therapy works by delivering therapeutic genes into target cells to express themselves and produce proteins acting directly against a given disease, in genetic vaccination the produced proteins act as antigens that illicit an immune response [7,8]. In future, genetic therapies ...
by Jac A. Nickoloff
Electrotransfer is a very useful application of electroporation because the DNA isolation step can be omitted. 6.
by Hidenori Akiyama, Richard Heller
Because electrotransfer is a physical method, delivery is theoretically possible to any tissue or cell type. This aspect has been demonstrated as the effective delivery has been accomplished in many tissue types and animal species and with a diversity of plasmids [79, 236, 237]. GET has also been successfully translated to the clinic. The first trial utilized microsecond pulses to successfully treat metastatic melanoma using gene-based immunotherapy . Clinical applications of GET ...
Drug Delivery (2017)
An Integrated Clinical and Engineering Approach by Yitzhak Rosen, Pablo Gurman, Noel Elman
THE ELECTROPORATION PROCEDURE DNA electrotransfer is a multistep process as reviewed in, for example, Escoffre et al. . The initial step is diffusion toward the cell. As mentioned, diffusion is much simpler in vitro and in vivo, and even between tissues, there are noticeable differences. Thus, in a tumor, cell adherence is often low, and DNA may distribute in the space between cells. Contrarily, DNA diffusion after injection intradermally may be notoriously difficult as there are ...
World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany (2010)
Vol. 25/XIII Special Topics and Workshops by Olaf Dössel, Wolfgang C. Schlegel
Abstract— Gene electrotransfer is an established method for gene delivery which uses high-voltage pulses to increase permeability of a cell membrane and thus enables transfer of genes. It was shown that critical steps of electrotransfection are cell electropermeabilization, contact of plasmid DNA with the cell membrane, translocation, entering the nucleus and gene expression. However, mechanisms of the processes are still not fully understood. In this paper we theoretically and ...
Gene and Cell Therapy (2015)
Therapeutic Mechanisms and Strategies, Fourth Edition by Nancy Smyth Templeton
Because of this versatility, electrotransfer is an important tool in disease therapeutics as it can be used to increase the bioavailability of chemotherapeutics such as bleomycin and cisplatin [18–20], to increase the expression of therapeutic FIGURE 15.2 Examples of some commercially available electrodes for in 331 ...
by Thomas Lathrop Stedman
test electrophoretogram electrotransfer test Elek test ELISA titer Ellsworth-Howard test ...
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Video about Electrotransfer
Video shows what electrotransfer means. the use of electroporation to transfer genetic material into cells. Electrotransfer Meaning. How to pronounce, definition ...
Scrabble value of E1L1E1C3T1R1O1T1R1A1N1S1F4E1R1
The value of this 15-letter word is 20 points, but it's not an accepted word in the Official Scrabble Players Dictionary.
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