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Acridine

Definition of the noun Acridine

What does Acridine mean as a name of something?

noun - plural: acridines

  1. [uncountable, organic compound] A tricyclic aromatic heterocycle, dibenzopyridine, obtained from coal tar; it is used in the manufacture of dyes and drugs
  2. [countable, organic chemistry] Any of many derivatives of this compound

Explanation

  1. Acridine is an organic compound and a nitrogen heterocycle with the formula C₁₃H₉N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is replaced by nitrogen. Like the related molecule pyridine and quinoline, acridine is mildly basic. It is an almost colorless solid. There are no commercial applications of acridines but at one time acridine dyes were popular. It crystallizes in needles.
  2. Acridine: A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death.

Printed books with definitions for Acridine

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Google previewHeterocyclic Chemistry (1999)

Reaction with Nucleophilic Reagents: The most outstanding chemical property of acridine is that it undergoes nucleophilic attack at...

Reaction with Oxidizing Agents: Acridine is a very stable ring system towards the action of oxidizing agents.

Google previewCommercial Organic Analysis: pt. I. Fixed oils, fats, waxes, glycerol, nitroglycerin and nitroglycerin explosives. 3d ed. with revisions and addenda by the author and Henry Leffmann. 189 (1900)

by Alfred Henry Allen, Henry Leffmann, Joseph Merritt Matthews, Arnold Rowsby Tankard

H Acnrnma, C,,H,N = Acridine is a basic N body which may be isolated by agitating crude anthracene with dilute sulphuric acid, precipitating the solution with potassium chromate, purifying the acridine chromate by recrystallisation, ...

Google previewHuman Genetics (2016)

by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewCommercial Organic Analysis: pt. I. Fixed oils, fats, waxes, glycerol, nitroglycerin and nitroglycerin explosives. 3d ed. with revisions and addenda by the author and Henry Leffmann. 1899 (1901)

by Alfred Henry Allen, Henry Leffmann, Joseph Merritt Matthews

ACRIDINE, Ci3H9N Acridine is a basic body which may be isolated by agitating crude anthracene with dilute sulphuric acid, precipitating the solution with potassium chromate, purifying the acridine chromate by recrystallisation, precipitating ...

Google previewGenetics, A Conceptual Approach (2016)

Biology, Genetics by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewConcepts of Genetics (2016)

by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewEssential Genetics (2016)

by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewLewin's GENES XI (2016)

by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewGenetics Essentials, Concepts and Connections (2016)

by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewStudent Solutions Manual and Supplemental Problems to Accompany Genetics: Analysis of Genes and Genomes (2011)

by Daniel L. Hartl, Maryellen Ruvolo

Acridine is an intercalating agent, and can be expected to produce frameshift mutations. 5-bromouracil is incorporated in place of T, but is sometimes read as C by DNA polymerase. Thus, 5-bromouracil-induced mutations would be expected ...

Google previewEnvironmental Microbiology (2016)

by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewOrganic Chemistry (2014)

A Mechanistic Approach by Penny Chaloner

Acridine is a nitrogen analogue of anthracene, isolated from coal tar. It is known to be a potent carcinogen and mutagen. Pyrimidine and purine are the parent compounds of the bases in nucleic acids ( Figure ...

Google previewSherris Medical Microbiology (2016)

by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewIndustrial Medicine Desk Reference (2012)

by David F. Tver

Acridine is a severe irritant to the conjunctiva of the eyes, the mucous membranes of the respiratory tract, andthe skin. Itisa powerful photosensitizer of the skin. It causes sneezing on inhalation. Yellowish discoloration of scleraand conjuctiva ...

Google previewGenetics, Analysis of Genes and Genomes (2016)

by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewGenetics, Analysis and Principles (2016)

by CTI Reviews

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups is ...

Google previewBiocatalysis in Oil Refining (2011)

Acridine is a three-ring nitrogen heterocycle, classified as polycyclic aromatic hydrocarbons (PAHs), some of which are proposed to be human carcinogens based on the evidence of carcinogenicity in experimental animals. Acridine is ...

Google previewCircular Dichroism (2000)

Principles and Applications by Nina Berova, Koji Nakanishi

9-Amino acridine is a convenient probe since it has two mutually perpendicular transition moments in the molecular plane oriented along the dye principal axes and the ICD on complexation may be deconvoluted into those of the separate ...

Google previewAdvances in Laser Chemistry (2012)

Proceedings of the Conference on Advances in Laser Chemistry, California Institute of Technology, Pasadena, USA, March 20–22, 1978 by A. H. Zewail

Acridine Apart from the interesting chemistry involving the triplet state and the present controversy over the fate of the first excited singlet state in nonhydrogen- bonding solvents, acridine is a weak base, of which both states of protonation are ...

Google previewThe Chemical News and Journal of Industrial Science (1871)

\Vhen quite pure, acridine is a colourless crystalline bod ; fuses at 107°; boils, without decomposition, at 360°; is very diflicultly soluble in boiling water, and not at all in cold; readily soluble in alcohol, ether, sulphide of carbon, and ...

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Video about Acridine

Acridine Meaning

Video shows what acridine means. A tricyclic aromatic heterocycle, dibenzopyridine, obtained from coal tar, it is used in the manufacture of dyes and drugs.

View more videos about Acridine orange.

Scrabble value of A1C3R1I1D2I1N1E1

The value of this 8-letter word is 11 points. It is included in the first and second editions of the Official Scrabble Players Dictionary.

Anagrams of ACRIDINE

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