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Anandamide

Definition of the noun Anandamide

What does Anandamide mean as a name of something?

noun

  1. [biochemistry] The ethanolamide of arachidonic acid; it binds to, and activates cannabinoid receptors in the brain

Explanation

Anandamide, also known as N-arachidonoylethanolamine or AEA, is an endogenous cannabinoid neurotransmitter. The name is taken from the Sanskrit word ananda, which means "joy, bliss, delight", and amide. It is synthesized from N-arachidonoyl phosphatidylethanolamine by multiple pathways. It is degraded primarily by the fatty acid amide hydrolase enzyme, which converts anandamide into ethanolamine and arachidonic acid. As such, inhibitors of FAAH lead to elevated anandamide levels and are being pursued for therapeutic use.

Printed dictionaries and other books with definitions for Anandamide

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Google previewBiology of Kundalini (2008)

by Jana Dixon

Anandamide is a recently discovered messenger molecule that plays a role in pain, depression, appetite, memory, and fertility. Its name comes from ananda, the Sanskrit word for “bliss.” Anandamide is synthesized enzymatically in areas of the brain that are important in memory...

Google previewTextbook of Gastroenterology (2011)

by Tadataka Yamada

Anandamide is an endogenous can-nabinoid and belongs to a family that has been shown to modulate hepatic fibrogenesis both in vitro and in vivo. Endocannabinoids bind to CB1 and CB2 receptors, which exert powerful profibrogenic and antifibrogenic effects, respectively [219,220]. Inhibition of the rennin–angiotensin system is probably the most promising strategy for treating liver fibrosis [12]. There is overwhelming experimental data indicating that pharmacological or genetic ...

Google previewCounseling Boys and Young Men (2012)

by Suzanne Degges-White, PhD, LMHC-IN, LPC-NC, NCC, Bonnie Colon, LMHC, NCC, NCSC

One such compound is called anandamide ( Sanskrit for bliss), ...

Google previewCommunication in Plants (2006)

Neuronal Aspects of Plant Life by F. Baluška, František Baluška, Stefano Mancuso, Dieter Volkmann

b Anandamide is an N-acylethanolamine (NAE) with a 20- carbon acyl chain and four double bonds. It has a wide range of neuromodulatory and physiological functions in vertebrates, and is drawn in two different conformations. c NAE types identified and quantified in plants CB receptors is somewhat surprising ...

Google previewPractice Questions in Psychopharmacology (2013)

by Srikanth Sajja, Ann Mortimer

Anandamide is an ethanolamide derivative of arachidonic acid. True. Benzodiazepines with longer half-lives are more likely to cause more severe withdrawal effects. False. Those with shorter half-lives cause more severe withdrawal symptoms. Study of the effects of the drug on the body is ' pharmacokinetics'. False. It is known as pharmacodynamics. 'Median toxic dose' is the dose at which 50 percent of patients experience a toxic effect. True. The ratio of the median toxic dose to the ...

Google previewEncyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances, 2d ed. (2015)

by David W. Group

Anandamide Discovered in1992 by Raphael Mechoulam,it is an endocannabinoid,or chemical producedby the body that is similar to THC, the psychoactive ingredient in marijuana. Effects: Identified in2004by neuroscientist Arne Dietrich of the Georgia Instituteof Technology asthe most likelycause of theflow state,or the athlete'sfeeling ofbeing “in thezone.”It isthought that anandamide helps endorphins cross the bloodbrain barrier,and that itis crucial toforgetting conditioned fear and ...

Google previewEncyclopedia of Neuroscience (2009)

Volume One by Larry R. Squire

several other receptors, in particular vanilloid TRPV1 receptor (anandamide stimulates Ca2+ influx, cation current, and depolarization), TASK-1 (anandamide inhibits outward K+ current), low- voltage-activated ...

Google previewEncyclopedia of the Neurological Sciences (2014)

Soon after, two endogenous ligands for the cannabinoid receptors were also identified, namely arachidonylethanolamide (anandamide) and 2- arachydonyl glycerol (2-AG). Anandamide shows selectivity for binding at the CB1 receptor, ↓ cAMP, ↓ Ca2+ whereas 2-AG shows affinity for both receptors. The enzymes ...

Google previewDictionary of Pharmaceutical Medicine (2017)

by Gerhard Nahler

anandamide/AEA, 2-arachidonoylglycerol/2-AG) that bind to cannabinoid receptors (CB1, CB2 receptors being the most prominent); these receptors are G- protein coupled receptors (GPCRs or GPRs) and mediate also the psychoactive effects of cannabis (CB1); ECs are involved in a variety of physiological processes, including appetite, mood, sleep, immune- and inflammatory processes, pain, ...

Google previewEncyclopedia of Movement Disorders (2010)

Several endocannabinoids have now been described, but arachydonoyl ethanolamide (anandamide) and 2-arachidonylglycerol (2-AG) are the best characterized. These are ecosanoid phospholipids produced on receptor-mediated demand in response to elevated intracellular calcium and immediately released. This is in ...

Google previewThe Dictionary of Cell and Molecular Biology (2012)

by John M. Lackie

Bind to the cannabinoid receptors and mimic actions of endogenous agonists anandamide and palmitoyl ethanolamine. cannabinoid receptors G-protein- coupled receptors for cannabinoids (and endogenous agonists such as anandamide). CB1 receptors (472aa) are mostly found in brain and may mediate the psychotropic activities; act by inhibiting adenylate cyclase and inhibit L-type Ca21 channel current. The CB2 receptors (360aa) are more peripheral and found extensively in the ...

Google previewEncyclopedia of Drug Policy (2011)

"the War on Drugs" Past, Present, and Future by James Hawdon, Mark Kleiman

Cannabinoid receptors generally are activated by anandamide, ...

Google previewEncyclopedia of Genetics, Genomics, Proteomics, and Informatics (2008)

by George P. Rédei

Anandamide also protect the central ...

Google previewEncyclopedia of Substance Abuse Prevention, Treatment, and Recovery (2009)

by Gary L. Fisher, Nancy A. Roget

The neurotransmitter, anandamide, has been suggested to be of importance during the early stages of pregnancy. This neurotransmitter, not discovered until 1995, acts on the limbic system and has been implicated as affecting emotions, motor coordination, and learning. It is generally found in high concentrations in mammalian uteri and may help regulate the early ...

Google previewSocial Issues in America: An Encyclopedia (2015)

An Encyclopedia by James Ciment

replace a natural brain chemical, anandamide, which binds to receptors in the cortex, basal ganglia, and cerebellum of the brain. THC is classified as a psychoactive drug, producing mild hallucinations, and as a depressant. Marijuana is typically administered by smoking crushed, dried leaves, seeds, and flowers. Two common preparations for smoking are marijuana rolled in cigarette papers, called a joint, and replacing tobacco in cigars, called a blunt. Bhang is the cheapest and ...

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Scrabble value of A1N1A1N1D2A1M3I1D2E1

The value of this 10-letter word is 14 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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