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Cytarabine

Definition of the noun Cytarabine

What does Cytarabine mean as a name of something?

noun

  1. A particular drug used in chemotherapy.

Explanation

  1. Cytarabine or cytosine arabinoside is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia and non-Hodgkin lymphoma. It is also known as ara-C. It kills cancer cells by interfering with DNA synthesis.
    • also known as Arabinosilcitosina, Ara-C, Arabinosina citosina, Citosina-arabinosídeo, Sitozin Arabisonit, Sitosin Arabisonit, Arabinósido de citocina
  2. Cytarabine: An antimetabolite analogue of cytidine with a modified sugar moiety. Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.

Printed dictionaries and other books with definitions for Cytarabine

Click on a title to look inside that book (if available):

Google previewAnticancer Therapeutics (2008)

by Sotiris Missailidis

N H H Cytarabine is an analogue of cytidine with arabinose instead of ribose. It is converted to the triphosphate form within the cell and then competes with cytidine for incorporation N N into DNA. The arabinose sugar sterically hinders the ...

Google previewFDA Bioequivalence Standards (2014)

by Lawrence X. Yu, Bing Li

DepoCyt is a sustained-release MVL formulation of the active ingredient cytarabine indicated for intrathecal treatment of lymphomatous meningitis (Sigma -Tau Pharmaceutical 2011). Cytarabine is a cell cycle phase-specific antineoplastic ...

Google previewHuman Developmental Toxicants (2006)

Aspects of Toxicology and Chemistry by James L. Schardein, Orest T. Macina

CO OH O INTRODUCTION Cytarabine is a purine antimetabolite ...

Google previewDrugs in Cancer Care (2013)

by Rachel Midgley, Mark R. Middleton, Andrew Dickman, David Kerr

Pharmacology Cytarabine is a cell cyclespecific cytotoxic, preferentially affecting cells in S phase. It acts as a cytosine analogue, competing with ...

Google previewSide-effects of Cancer Chemotherapy on the Gastrointestinal Tract (2003)

Pathophysiology, Prophylaxis and Therapy by M. Staritz, G. Adler, W. Schmiegel, A. Knuth

Cytarabine is a structure-analogue of 2-deoxycytidine: its mechanism of action is provided by a stereoisomer of deoxycytidine (3-OH trans, not cis configuration) that results in steric hindrance of pyrimidine base rotation around the ...

Google previewCurrent Controversies in Bone Marrow Transplantation (1999)

by Brian J. Bolwell

Topotecan and high-dose cytarabine is an active ...

Google previewBiochemistry (1999)

by Victor L. Davidson, Donald B. Sittman

Cytarabine is a dideoxynucleoside analog (see Chapter 8). Upon phosphorylation after cell entry, it becomes incorporated into DNA, where it slows the rate of replication and alters the structure of DNA such that it is more prone to breakage.

Google previewPrimary Care, Second Edition (2014)

An Interprofessional Perspective by Joanne K. Singleton

Cytarabine is an antimetabolite that acts through the inhibition of DNA polymerase. Thus, it blocks cell replication in part by killing cells undergoing DNA synthesis. Cytarabine may be used in conjuction with other drugs for induction treatment ...

Google previewAbeloff's Clinical Oncology E-Book (2013)

by John E. Niederhuber, James O. Armitage, James H Doroshow, Michael B. Kastan, Joel E. Tepper

Patients With AML Who Are Not Candidates for Intensive Therapy • Low-dose cytarabine is a generally accepted therapy for patients with AML who are not candidates for intensive therapy. Recent alternatives include decitabine, azacitidine, ...

Google previewApplied Pharmacology (2010)

by Stan Bardal, Jason Waechter, Doug Martin

n Myelosuppression: Cytarabine is a particularly potent bone marrow suppressant. n GI effects are caused by irritation of GI epithelium. n Stomatitis may occur. n Hepatotoxicity: Reversible elevations in liver enzymes may develop. n CNS: CNS ...

Google previewSupportive Care in Pediatric Oncology (2015)

A Practical Evidence-Based Approach by James Feusner, Caroline A. Hastings, Anurag K. Agrawal

Although this same report demonstrated that some patients may be rechallenged without permanent neurologic damage, the decision to proceed with additional cytarabine is a difficult one. Identified risk factors for cerebellar syndrome include ...

Google previewBlueprints Notes and Cases, Pharmacology (2004)

by Aaron B. Caughey

Cytarabine is a pyrimidine analogue used primarily in the treatment of leukemias. In high doses, this agent is associated with myelosuppression, rash (which may be severe), chemical conjunctivitis, and cerebellar dysfunction (especially when ...

Google previewThomas' Hematopoietic Cell Transplantation (2004)

by E. Donnall Thomas, Karl G. Blume, Stephen J. Forman, Frederick R. Appelbaum

Cytarabine (Table 13.2) Cytarabine is a cell cycle specific antineoplastic agent that affects cells only in S-phase. Although its mechanism of action is not fully understood, it metabolite cytarabine-triphosphate is believed to inhibit the action of ...

Google previewEncyclopedia of Molecular Pharmacology

by Stefan Offermanns

Cytarabine (cytosine arabinoside, ara C, Fig. 6) is an analog of the pyrimidine nucleosides. It is one of the most potent agents available for treating acute myeloid leukemia. The drug must first be activated by pyrimidine nucleoside kinase to the ...

Google previewPharmaceutical Manufacturing Encyclopedia, 3rd Edition (2013)

by William Andrew Publishing

Cytarabine ...

Google previewEncyclopedia of the Neurological Sciences (2014)

Table 2 Neurotoxic syndromes caused by antineoplastic drugs Table 2 Continued Syndrome Responsible agents Syndrome Responsible agents Acute/ subacute encephalopathy Cytarabine (high-dose IV) Asparaginase Cisplatin ...

Google previewConcise Medical Dictionary (2015)

by Elizabeth Martin

cytarabine. n. an *antimetabolite that interferes with pyrimidine synthesis and is used to suppress the symptoms of acute myeloblastic leukaemia and lymphomatous meningitis. It is administered by subcutaneous, intravenous, or * intrathecal ...

Google previewConcise Dictionary of Modern Medicine (2010)

by Joseph Segen

cytarabine. AraC, cytosine arabinoside Oncology An antimetabolite analogue of deoxycytidine, used synergistically with antifolates, alkylating agents, and cisplatinum to treat AML Pharmacokinetics Poorly absorbed–±20% absorbed orally, ...

Google previewBlack's Student Medical Dictionary (2015)

by Harvey Marcovitch

Cytarabine A drug used mainly to induce remission of acute myeloblastic LEUKAEMIA. A potent suppressant of MYELOBLASTS, its use requires monitoring by a HAEMATOLOGIST. (See CYTOTOXIC.) Cyto A prefix meaning ...

Google previewThe SAGE Encyclopedia of Cancer and Society (2015)

by Graham A. Colditz

Fifth, the components of the CODOX-M/IVAC regimen are cyclophosphamide, doxorubicin, high-dose methotrexate or ifosfamide, etoposide, and high-dose cytarabine. It is given with HAART and given for the treatment of aggressive ...

Google previewInverted Medical Dictionary, Second Edition (1991)

by Bruce C. Carlstedt, Mary J. Stanaszek, Walter F. Stanaszek

acyclovir adenosine deaminase antidiuretic hormone doxorubicin doxorubicin/vincristine/ cytarabine/prednisone adenosine diphosphate doxorubicin (Adriamycin®) aminoglycoside silver nitrate ...

Google previewEncyclopedia of Toxicology (2005)

by Bruce Anderson, Ann de Peyster, Shayne C. Gad, P.J. Bert Hakkinen, Michael Kamrin, Betty Locey, Harihara M. Mehendale, Carey Pope, Lee Shugart

Carmustine a Azacitidine Altretamine Cytarabine Cisplatin Carboplatin Daunorubicin Docetaxel Cyclophosphamide a Carmustine Doxorubicin Etoposide Cytarabine a ...

Google previewMosby's Dictionary of Medicine, Nursing and Health Professions - Australian & New Zealand Edition (2014)

by Peter Harris, Sue Nagy, Nicholas Vardaxis

See cytarabine. arabinosylcytosine. See cytarabine. arachidonic acid / arމۑkidonމik/ [Gk, arachis, peanut], a long-chain fatty acid that is a component of lecithin and a basic material in the biosynthesis of some prostaglandins. In mammals ...

Google previewBlack's Medical Dictionary (2005)

by Bloomsbury Publishing

Cytarabine irritation or another cause, some cavity which ought naturally to contain a little fluid becomes distended, or the natural outlet from the cavity becomes blocked. Wens are caused by the blockage of the outlet from sebaceous ...

Google previewCancer Dictionary (2004)

by Henry A. Rose

DepoFoam-encapsulated cytarabine The anticancer drug cytarabine formulated inside small particles of a synthetic lipid material called DepoFoam. This dosage form slowly releases the drug and provides a sustained action. depsipeptide ...

Google previewThe Dictionary of Virology (2009)

by Brian W.J. Mahy

1-β-D-arabinofuranosylcytosine hydrochloride See cytarabine hydrochloride. 1-β -D-arabinofuranosylthymidine See spongothymidine. 1-β-D- arabinofuranosyluracilSeespongouridine. arabinosyl adenine See adenine arabinoside. arabinosyl ...

Google previewDictionary of Carbohydrates (1997)

by Peter M. Collins

Cytarabine, USAN, INN, JAN, BAN. Cylosar-U. Aracylidine. Ara-C. Aracytin. Alexan. Tarabine. NSC 63878. V 19920 Isol. from the mushroom Xerocomus ...

Google previewMerriam-Webster's Medical Dictionary (1995)

by Merriam-Webster, Inc, Roger W. Pease, Jr.

cytarabine. •. cytophotometry. cy«toho«y \si-'ta-la-je\ n, pl -cits 1 : a branch of biology dealing with the structure, function, multiplication, pathology, and life history of cells 2 ...

Google previewThe Dictionary of Drugs: Chemical Data (2014)

Chemical Data, Structures and Bibliographies by J. Elks

Cytarabine, USAN, INN, JAN, BAN. Cytosar-U. Aracytidine. Ara-C. Other synonyms Antineoplastic and antiviral agent. Prisms ( EtOH ...

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Video about Cytarabine

Cytarabine Meaning

Video shows what cytarabine means. A particular drug used in chemotherapy.. cytarabine synonyms: cytosine arabinoside. Cytarabine Meaning. How to ...

Scrabble value of C3Y4T1A1R1A1B3I1N1E1

The value of this 10-letter word is 17 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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