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Exalgo is a brand, drug brand.


Exalgo a.k.a. Hydromorphone: The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate for guanosine diphosphate on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate. Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.

Printed encyclopedias and other books with definitions for Exalgo

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Google previewSaunders Handbook of Veterinary Drugs (2015)

Small and Large Animal by Mark G. Papich

Hydroxyethyl Starch • Exalgo is an extended-release formulation for people in 8-, 12-, and 16-mg tablets that allows for once-daily treatment. This formulation has not been evaluated in animals. Stability and Storage Store in a tightly ...

Google previewA Physician's Guide to Pain and Symptom Management in Cancer Patients (2014)

by Janet L. Abrahm, Amanda Moment, Arden O'Donnell

Exalgo is a sustained-release form of hydromorphone that is taken daily. In 2005, the makers of Palladone, another form of sustained-release hydromorphone, withdrew it because of concerns of overdose if the pill was taken with alcohol.

Google previewCHE-MOment (2013)

Life Lessons, Facing Death, and Surviving Cancer (AML M2) Leukemia and beyond. A Medical Rep’s story of how FAITH, POSITIVE ATTITUDE, and EXERCISE can beat the odds. by Chris J. Hamilton

Exalgo —Also known as Hydromorphone Hydrochloride. Exalgo is a mu-opioid agonist ...

Google previewThe Lupus Encyclopedia (2014)

A Comprehensive Guide for Patients and Families by Donald E. Thomas, Jr.

See flares Exalgo (hydromorphone), 630 exemestane (Aromasin), 358 exercise: aerobic exercise, ...

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Scrabble value of E1X8A1L1G2O1

The value of this 6-letter word is 14 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

Anagrams of EXALGO

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