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Exalgo is a brand, drug brand.
Exalgo a.k.a. Hydromorphone: The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate for guanosine diphosphate on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate. Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.
Printed encyclopedias and other books with definitions for Exalgo
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Small and Large Animal by Mark G. Papich
Hydroxyethyl Starch • Exalgo is an extended-release formulation for people in 8-, 12-, and 16-mg tablets that allows for once-daily treatment. This formulation has not been evaluated in animals. Stability and Storage Store in a tightly ...
by Janet L. Abrahm, Amanda Moment, Arden O'Donnell
Exalgo is a sustained-release form of hydromorphone that is taken daily. In 2005, the makers of Palladone, another form of sustained-release hydromorphone, withdrew it because of concerns of overdose if the pill was taken with alcohol.
Life Lessons, Facing Death, and Surviving Cancer (AML M2) Leukemia and beyond. A Medical Rep’s story of how FAITH, POSITIVE ATTITUDE, and EXERCISE can beat the odds. by Chris J. Hamilton
Exalgo —Also known as Hydromorphone Hydrochloride. Exalgo is a mu-opioid agonist ...
The Lupus Encyclopedia (2014)
A Comprehensive Guide for Patients and Families by Donald E. Thomas, Jr.
See flares Exalgo (hydromorphone), 630 exemestane (Aromasin), 358 exercise: aerobic exercise, ...
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Scrabble value of E1X8A1L1G2O1
The value of this 6-letter word is 14 points, but it's not an accepted word in the Official Scrabble Players Dictionary.
Anagrams of EXALGO
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