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Indiplon

Explanation

Indiplon is a nonbenzodiazepine, hypnotic sedative that was developed in 2 formulations - an immediate release product for sleep onset and a modified-release version for sleep maintenance.

Printed books with definitions for Indiplon

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Google previewComprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches (2013)

The AMERICAN ACADEMY OF PAIN MEDICINE Textbook on Patient Management by Timothy R. Deer, Michael S. Leong, Asokumar Buvanendran, Vitaly Gordin, Philip S. Kim, Sunil J. Panchal, Albert L. Ray

Indiplon is a novel pyrazolopyrimidine, nonbenzodiazepine g-aminobutyric acid (GABA) agonist with a high affinity and selectivity for the a1 subunit associated with sedation for the treatment of insomnia [29].

Google previewDrug Repositioning (2012)

Bringing New Life to Shelved Assets and Existing Drugs by Michael J. Barratt, Donald E. Frail

Indiplon is a GABAA receptor agonist that was in development for the treatment of insomnia. The D3-indiplon compound showed an approximate twofold increase in half-life when orally dosed to rats. Linezolid (Zyvox®) is the only oxazolidinone antibiotic approved for the both intravenous (IV) and oral treatment of susceptible and resistant Gram-positive pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).

Google previewGABA and Sleep (2010)

Molecular, Functional and Clinical Aspects by Jaime M. Monti, Seithikurippu Ratnas Pandi-Perumal, Hanns Möhler

Neubauer Abstract Indiplon is an investigational hypnotic that has been evaluated in efficacy and safety studies as a possible treatment for insomnia. It is a positive allosteric modulator of GABA responses at the GABAA receptor complex and has selectivity for receptors containing the a1 subunit subtype. The compound's short elimination half-life has allowed the development of immediate -release and modified-release formulations. Clinical trials have been conducted with ...

Google previewBasic Concepts of Psychiatric-mental Health Nursing (2008)

by Louise Rebraca Shives

Indiplon is an investigational nonbenzodiazepine drug that may Soon be ...

Google previewPsychiatric Mental Health Nursing (2014)

by Katherine M. Fortinash, Patricia A. Holoday Worret

Indiplon is an indirect γ-aminobutyric acid agonist. Other Agents Used for Sleep Trazodone. Mechanism of Action. Trazodone is a serotonin reuptake inhibitor that blocks serotonin receptors. The dose as a hypnotic is 50 to 200 mg at bedtime. Pharmacokinetics. There is delayed onset, with a long half-life of 6 hours that may be longer for older adults and obese patients. Side effects are sedation and orthostatic hypotension. Priapism, which is a rare but serious adverse effect, sometimes ...

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Scrabble value of I1N1D2I1P3L1O1N1

The value of this 8-letter word is 11 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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