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Mipomersen

Definition of the noun Mipomersen

What does Mipomersen mean as a name of something?

noun

  1. [medicine] An oligonucleotide drug used to reduce cholesterol levels

Explanation

Mipomersen is a cholesterol-reducing drug candidate. It is an antisense therapeutic that targets the messenger RNA for apolipoprotein B. It is administered as a weekly injection.

Printed books with definitions for Mipomersen

Click on a title to look inside that book (if available):

Google previewMolecular Probes: Advances in Research and Application: 2011 Edition (2012)

ScholarlyPaper

According to recent research published in the journal Current Opinion In Lipidology, “Mipomersen is a second-generation antisense oligonucleotide developed to inhibit the synthesis of apolipoprotein B-100 in the liver. In this review we will ...

Google previewHandbook of Lipidology (2016)

by Tapan Ghose

Mipomersen is an antisense oligonucleotide that targets mRNA encoding ApoB100.

Google previewPreventive Nutrition (2016)

The Comprehensive Guide for Health Professionals by Adrianne Bendich, Richard J. Deckelbaum

Mipomersen is a valuable addition to the management of dyslipidemia, resulting in significant lowering of serum LDLcholesterol and triglycerides but at the cost of significant hepatic transaminitis (>30 %) [140]. Tesamorelin is an analog of ...

Google previewCardiovascular Diseases (2016)

Genetic Susceptibility, Environmental Factors and their Interaction by Nikolaos Papageorgiou

Mipomersen is a single-stranded, antisense oligonucleotide that binds to a mRNA that encodes apolipoprotein B-100. Lomitapide inhibits the microsomal triglyceride transfer protein (MTP), resulting in the reduction of chylomicrons and VLDL ...

Google previewTextbook of Interventional Cardiology (2015)

by Eric J. Topol, Paul S. Teirstein

Antisense to Apolipoprotein B Mipomersen is an antisense oligonucleotide designed to reduce apo B-100 ...

Google previewFamilial Hypercholesterolemia: New Insights for the Healthcare Professional: 2013 Edition (2013)

ScholarlyPaper

Mipomersen is an oligonucleotide inhibitor of apolipoprotein B-lOO synthesis ( called an antisense inhibitor) indicated as an adjunct to lipid-lowering medications and diet to reduce LDL-C, apolipoprotein B, total cholesterol, and non-high ...

Google previewLDL Lipoproteins: Advances in Research and Application: 2011 Edition (2012)

ScholarlyBrief

Mipomersen is an apolipoprotein (apo) B synthesis inhibitor that has demonstrated significant reductions in apo B and low-density lipoprotein (LDL) cholesterol in Phase 1 clinical trials in healthy volunteers,” scientists writing in the Journal of ...

Google previewCombination Therapy In Dyslipidemia (2015)

by Maciej Banach

Mipomersen is a 2'-O-methoxyethyl chimeric 20-mer oligonucleotide complementary to the coding region of human apoB-100 mRNA, modified to withstand almost all nuclease degradation [32]. Once the apoB ASO binds to the apoB mRNA, ...

Google previewMetabolic Control (2016)

by Stephan Herzig

Mipomersen is a new and attractive alternative to LDL apheresis for these patients. ApoB RNAi-Approaches For apolipoprotein B-100, several RNA- silencing drugs are investigated in clinical trials. Using the SNALP technology ( Rozema et al.

Google previewCoronary Artery Disease (2015)

by James T. Willerson, David R. Holmes, Jr.

Mipomersen is a second-generation antisense oligonucleotide (Fig. 3.5) that binds to the mRNA sequence encoding apo B and leads to dose-dependent reductions in LDL-C, apo B, and Lp(a) levels [139, 140]. A once-weekly subcutaneous ...

Google previewAtherosclerosis (2015)

Risks, Mechanisms, and Therapies by Hong Wang

Mipomersen is an antisense oligonucleotide that targets the mrnA for ApoB and is in phase III clinical trials. It has been shown to significantly reduce LdL-C in patients with homozygous familial hypercholesterolemia, and may also be useful in ...

Google previewGenomic Essentials for Graduate Level Nurses (2016)

by Diane C. Seibert, Quannetta T. Edwards, Ann H. Maradiegue, Susan T. Tinley

Mipomersen is a once-weekly ...

Google previewRoach's Introductory Clinical Pharmacology (2013)

by Susan M. Ford, Sally S. Roach

On the other hand, mipomersen is a chemically engineered drug being studied to target specific cell compo- nents ...

Google previewHandbook of Pharmacogenomics and Stratified Medicine (2014)

Antisense Oligonucleotide Therapies Mipomersen is an antisense oligonucleotide therapy that specifically binds to the apolipoprotein B-100 mRNA, blocking translation of the gene product. The reduction in production of apo B- 100 results in ...

Google previewPharmacotherapeutics For Advanced Practice Nurse Prescribers (2015)

by Teri Moser Woo, Marylou V Robinson

Mipomersen is a weekly injection associated with a 24% reduction in LDL. Lomitapride is an oral medication in a new class of drugs that inhibits bowel enzymes that help manufacture cholesterol in the liver. It lowered LDL by 47% in a small ...

Google previewDyslipidemias (2015)

Pathophysiology, Evaluation and Management by Abhimanyu Garg

Mipomersen is an antisense apo B-100 mRNA recently approved for the treatment of homozygous FH. It is administered subcutaneously as a weekly injection. In a randomized, double-blind, placebo-controlled study with 34 patients, the mean ...

Google previewPharmaceutics (2013)

Basic Principles and Application to Pharmacy Practice by Alekha Dash, Somnath Singh, Justin Tolman

Mipomersen (Kynamros) Mipomersen is an antisense oligonucleotide that inhibits the synthesis of apo B-100 involved in the production of low-density lipoprotein and very lowdensity lipoprotein associated with familial ...

Google previewClinical Cardiogenetics (2016)

by H.F. Baars, P.A.F.M. Doevendans, Arjan C. Houweling, J. Peter van Tintelen

Mipomersen is an ASO that in 2013 was approved by the FDA for use in patients with homozygous FH (HoFH), although it is still not approved in Europe. It lowered LDL-C with 25% in patients already receiving lipid-lowering drugs, while also ...

Google previewFerri's Clinical Advisor 2018 E-Book (2017)

5 Books in 1 by Fred F. Ferri

Conclusions: Mipomersen is an effective therapy to further reduce apolipoprotein B-containing lipoproteins, including LDL and lipoprotein(a), in HeFH patients with coronary artery disease on statins and other lipid-lowering therapy.

Google previewFerri's Clinical Advisor 2017 (2016)

5 Books in 1 by Fred F. Ferri

Conclusions: Mipomersen is an effective therapy to further reduce apolipoprotein B-containing lipoproteins, including LDL and lipoprotein(a), in HeFH patients with coronary artery disease on statins and other lipid-lowering therapy.

Google previewHenry's Clinical Diagnosis and Management by Laboratory Methods E-Book (2016)

by Richard A. McPherson, Matthew R. Pincus

Mipomersen is an antisense oligonucleotide that inhibits production of apoB-100. It is administered as a subcutaneous injection once a week. Mipomersen also was initially developed for patients with lipid disorders but was ultimately targeted ...

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Video about Mipomersen

Mipomersen Meaning

Video shows what mipomersen means. An oligonucleotide drug used to reduce cholesterol levels. Mipomersen Meaning. How to pronounce, definition audio ...

Scrabble value of M3I1P3O1M3E1R1S1E1N1

The value of this 10-letter word is 16 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

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