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Definition of the noun Prenylation
What does Prenylation mean as a name of something?
- See isoprenylation.
Prenylation is the addition of hydrophobic molecules to a protein or chemical compound. It is usually assumed that prenyl groups facilitate attachment to cell membranes, similar to lipid anchor like the GPI anchor, though direct evidence is missing. Prenyl groups have been shown to be important for protein-protein binding through specialized prenyl-binding domains.
Printed dictionaries and other books with definitions for Prenylation
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Protein prenylation is a post-translational event that facilitates the anchoring of certain proteins to cellular membranes (Scheme 1). Examples of post- translationally prenylated proteins are (small) GTP binding proteins that function as molecular ...
by Ronald Ross Watson, Douglas F. Larson
Prenylation is a process involving the binding of hydrophobic isoprenoid groups consisting of farnesyl or geranylgeranyl residues to the C-terminal region of Ras protein superfamily. FPP and GGPP are metabolic products of mevalonate that ...
Zakim and Boyer's Hepatology (2016)
A Textbook of Liver Disease E-Book by Thomas D. Boyer, Arun J. Sanyal, Norah A Terrault, Keith D Lindor
128,129 Prenylation is a posttranslational lipid modification that involves ...
by Yuri F. Belyi
Since prenylation is a stable and irreversible modification of proteins it has been speculated that these GDIs may mask the hydrophobicity of attached lipid groups to allow dissociation of Rho and Rab from membranes.” Thus these GDIs may ...
by Shaul Yalovsky, František Baluška, Alan Jones
Prenylation and CaaX Processing 2.1.1 Prenylation Protein prenylation is a posttranslational protein modification that involves the formation ...
Introduction to Proteins (2010)
Structure, Function, and Motion by Amit Kessel, Nir Ben-Tal
S-Prenylation Prenylation is a process of transferring an isoprene-based chain to the sulfur atom of cysteine. The transferred chain is either the 15-carbon farnesyl (Figure 2.37g), or the 20-carbon geranyl-geranyl (Figure 2.37h).
New Concepts and Experimental Approaches by Thomas J. Bach, Michel Rohmer
Protein prenylation is a posttranslational modification resulting in thioether linkage of a 15-carbon farnesyl, or 20-carbon geranylgeranyl, moiety to a cysteine residue at or near the carboxyl terminus of a protein. Most prenylated proteins are ...
by Paul F. Torrence
PROTEIN PRENYLATION: A POST-TRANSLATIONAL MODIFICATION Prenylation is a post-translational lipid modification of proteins that involves the covalent addition of an isoprene, or prenyl, group to a cysteine residue located within ...
Hemostasis and Thrombosis (2012)
Basic Principles and Clinical Practice by Victor J. Marder, William C. Aird, Joel S. Bennett, Sam Schulman, Gilbert C. White, II
Prenylation is a posttranslational process also catalyzed by soluble enzymes. It involves the attachment of a prenyl group— either a farnesyl or a geranyl of 15 or 20 carbon atoms respectively —onto soluble proteins that carry a CaaX motif (C ...
by Lei Liu
Prenylation Prenylation is a posttranslational addition of C15 (farnesyl) 142 A. Yang et al.
by Monika Waksmundzka-Hajnos, Joseph Sherma
Notably, prenylation is an important step, because of its presence in the biosynthetic pathway of polycyclic coumarins like furocoumarins and pyranocoumarins [4,8]. Higher plants synthesize coumarins via the shikimate– chorismate ...
Encyclopedia of Cancer (2011)
by Manfred Schwab
Minodronate, a nitrogencontaining bisphosphonate, acts intracellularly by inhibiting farnesyl pyrophosphate synthase, thus leading to the inhibition of posttranslational prenylation of small molecular weight G proteins, which could also ...
by George P. Rédei
Prenylation: The attachment of a farnesyl alcohol, in thioeter linkage, with a cystein residue located near the carboxyl terminus of the polypeptide chain. The donor is frequently farnesyl pyrophosphate. CH3 O O O− O− H CH3 Squalene H 4 ...
Encyclopedia of Cell Biology (2015)
Protein Prenylation The hydrophobicity of a protein can be modified by the covalent addition of lipids. For example, several proteins, such as Ras and Ras- related GTP-binding proteins undergo prenylation (the addition of isoprenoid groups) in ...
A Dictionary of Genetics (2006)
by Robert C. King, William D. Stansfield, Pamela Khipple Mulligan
prenylation the covalent binding of a protein to an isoprenoid lipid (q.v.), generally by its C-terminal ...
by J.C. Segen
see Fragile X syndrome, Hereditary neoplasms, Premalignancy Prenylation MOLECULAR BIOLOGY A post-translational modification of protein involving the addition of unit (s) of ...
Dictionary of Rheumatology (2015)
by Jozef Rovenský, Juraj Payer, Manfred Herold
Thus, interference with mevalonate and rarely protein prenylation occurs. The final consequence is impaired function, damage to cytoskeleton and decreased osteoclast survival. The bone tissue resorption is reduced and the bone turnover ...
by Lindsay H Allen, Andrew Prentice
is a key enzyme for MK-4 biosynthesis, and possesses side chain cleavage and prenylation activities. Most bacterially synthesized menaquinones have longer ...
The Dictionary of Virology (2009)
by Brian W.J. Mahy
Phytochemical Dictionary (1998)
A Handbook of Bioactive Compounds from Plants, Second Edition by Herbert Baxter, J.B. Harborne, Gerald P. Moss
Iso- prenylation of this key intermediate in either the 6- or 8- position, followed by ring ...
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Scrabble value of P3R1E1N1Y4L1A1T1I1O1N1
The value of this 11-letter word is 16 points, but it's not an accepted word in the Official Scrabble Players Dictionary.
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