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Definition of the noun Prenylation

What does Prenylation mean as a name of something?


  1. See isoprenylation.


Prenylation is the addition of hydrophobic molecules to a protein or chemical compound. It is usually assumed that prenyl groups facilitate attachment to cell membranes, similar to lipid anchor like the GPI anchor, though direct evidence is missing. Prenyl groups have been shown to be important for protein-protein binding through specialized prenyl-binding domains.

Printed dictionaries and other books with definitions for Prenylation

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Google previewFrontiers in Medicinal Chemistry (2010)

Protein prenylation is a post-translational event that facilitates the anchoring of certain proteins to cellular membranes (Scheme 1). Examples of post- translationally prenylated proteins are (small) GTP binding proteins that function as molecular ...

Google previewImmune Dysfunction and Immunotherapy in Heart Disease (2008)

by Ronald Ross Watson, Douglas F. Larson

Prenylation is a process involving the binding of hydrophobic isoprenoid groups consisting of farnesyl or geranylgeranyl residues to the C-terminal region of Ras protein superfamily. FPP and GGPP are metabolic products of mevalonate that ...

Google previewZakim and Boyer's Hepatology (2016)

A Textbook of Liver Disease E-Book by Thomas D. Boyer, Arun J. Sanyal, Norah A Terrault, Keith D Lindor

128,129 Prenylation is a posttranslational lipid modification that involves ...

Google previewIntracellular Parasitism of Microorganisms (2013)

by Yuri F. Belyi

Since prenylation is a stable and irreversible modification of proteins it has been speculated that these GDIs may mask the hydrophobicity of attached lipid groups to allow dissociation of Rho and Rab from membranes.” Thus these GDIs may ...

Google previewIntegrated G Proteins Signaling in Plants (2009)

by Shaul Yalovsky, František Baluška, Alan Jones

Prenylation and CaaX Processing 2.1.1 Prenylation Protein prenylation is a posttranslational protein modification that involves the formation ...

Google previewIntroduction to Proteins (2010)

Structure, Function, and Motion by Amit Kessel, Nir Ben-Tal

S-Prenylation Prenylation is a process of transferring an isoprene-based chain to the sulfur atom of cysteine. The transferred chain is either the 15-carbon farnesyl (Figure 2.37g), or the 20-carbon geranyl-geranyl (Figure 2.37h).

Google previewIsoprenoid Synthesis in Plants and Microorganisms (2012)

New Concepts and Experimental Approaches by Thomas J. Bach, Michel Rohmer

Protein prenylation is a posttranslational modification resulting in thioether linkage of a 15-carbon farnesyl, or 20-carbon geranylgeranyl, moiety to a cysteine residue at or near the carboxyl terminus of a protein. Most prenylated proteins are ...

Google previewAntiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats (2005)

by Paul F. Torrence

PROTEIN PRENYLATION: A POST-TRANSLATIONAL MODIFICATION Prenylation is a post-translational lipid modification of proteins that involves the covalent addition of an isoprene, or prenyl, group to a cysteine residue located within ...

Google previewHemostasis and Thrombosis (2012)

Basic Principles and Clinical Practice by Victor J. Marder, William C. Aird, Joel S. Bennett, Sam Schulman, Gilbert C. White, II

Prenylation is a posttranslational process also catalyzed by soluble enzymes. It involves the attachment of a prenyl group— either a farnesyl or a geranyl of 15 or 20 carbon atoms respectively —onto soluble proteins that carry a CaaX motif (C ...

Google previewProtein Ligation and Total Synthesis I (2015)

by Lei Liu

Prenylation Prenylation is a posttranslational addition of C15 (farnesyl) 142 A. Yang et al.

Google previewHigh Performance Liquid Chromatography in Phytochemical Analysis (2010)

by Monika Waksmundzka-Hajnos, Joseph Sherma

Notably, prenylation is an important step, because of its presence in the biosynthetic pathway of polycyclic coumarins like furocoumarins and pyranocoumarins [4,8]. Higher plants synthesize coumarins via the shikimate– chorismate ...

Google previewEncyclopedia of Cancer (2011)

by Manfred Schwab

Minodronate, a nitrogencontaining bisphosphonate, acts intracellularly by inhibiting farnesyl pyrophosphate synthase, thus leading to the inhibition of posttranslational prenylation of small molecular weight G proteins, which could also ...

Google previewEncyclopedia of Genetics, Genomics, Proteomics, and Informatics (2008)

by George P. Rédei

Prenylation: The attachment of a farnesyl alcohol, in thioeter linkage, with a cystein residue located near the carboxyl terminus of the polypeptide chain. The donor is frequently farnesyl pyrophosphate. CH3 O O O− O− H CH3 Squalene H 4 ...

Google previewEncyclopedia of Cell Biology (2015)

Protein Prenylation The hydrophobicity of a protein can be modified by the covalent addition of lipids. For example, several proteins, such as Ras and Ras- related GTP-binding proteins undergo prenylation (the addition of isoprenoid groups) in ...

Google previewA Dictionary of Genetics (2006)

by Robert C. King, William D. Stansfield, Pamela Khipple Mulligan

prenylation the covalent binding of a protein to an isoprenoid lipid (q.v.), generally by its C-terminal ...

Google previewThe Dictionary of Modern Medicine (1992)

by J.C. Segen

see Fragile X syndrome, Hereditary neoplasms, Premalignancy Prenylation MOLECULAR BIOLOGY A post-translational modification of protein involving the addition of unit (s) of ...

Google previewDictionary of Rheumatology (2015)

by Jozef Rovenský, Juraj Payer, Manfred Herold

Thus, interference with mevalonate and rarely protein prenylation occurs. The final consequence is impaired function, damage to cytoskeleton and decreased osteoclast survival. The bone tissue resorption is reduced and the bone turnover ...

Google previewEncyclopedia of Human Nutrition (2012)

by Lindsay H Allen, Andrew Prentice

is a key enzyme for MK-4 biosynthesis, and possesses side chain cleavage and prenylation activities. Most bacterially synthesized menaquinones have longer ...

Google previewThe Dictionary of Virology (2009)

by Brian W.J. Mahy

prenylation ...

Google previewPhytochemical Dictionary (1998)

A Handbook of Bioactive Compounds from Plants, Second Edition by Herbert Baxter, J.B. Harborne, Gerald P. Moss

Iso- prenylation of this key intermediate in either the 6- or 8- position, followed by ring ...

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Prenylation Meaning

Video shows what prenylation means. isoprenylation. Prenylation Meaning. How to pronounce, definition audio dictionary. How to say prenylation. Powered by ...

Scrabble value of P3R1E1N1Y4L1A1T1I1O1N1

The value of this 11-letter word is 16 points, but it's not an accepted word in the Official Scrabble Players Dictionary.


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