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Tasigna

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Tasigna is a brand, drug brand.

Miscellanea

Tasigna a.k.a. Nilotinib: An orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome imatinib resistance, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive chronic myeloid leukemia cells. This agent also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors. With a binding mode that is energetically more favorable than that of imatinib, nilotinib has been shown to have an approximately 20-fold increased potency in kinase and proliferation assays compared to imatinib.

  • also known as 尼罗替尼

Printed dictionaries and other books with definitions for Tasigna

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Google previewDictionary of Chemistry

All Terms of Chemistry by Engineering Bug

Tasigna : A drug used to treat certain types of chronic myelogenous leukemia ( CML). It is used in some newly diagnosed patients. It is also used in patients who have not gotten better after treatment with other anticancer drugs or who are not ...

Google previewConcise Colour Medical Dictionary (2015)

by Elizabeth Martin

and nilotinib (Tasigna), used for treating chronic 781 tyrosinosis myeloid leukaemia; *sunitinib, for treating renal cell carcinoma;

Google previewConcise Medical Dictionary (2015)

by Elizabeth Martin

and nilotinib (Tasigna), used for treating chronic 781 tyrosinosis myeloid leukaemia; *sunitinib, for treating renal cell carcinoma;

Google previewMosby's Pocket Dictionary of Medicine, Nursing & Health Professions (2013)

by Mosby

tabula rasa m tache noire tachistoscope tachometer tachyarrhythmia tachycardia tachycardia-bradycardia syndrome tachycardiac tachyphagia tachyphylaxis tachypnea artar tartaric acid HOOC(CH m COOH tartrate Tarui's disease Tasigna.

Google previewMosby's Medical Dictionary (2016)

by Mosby

Tasigna, a chemotherapeutic agent. Brand name for nilotinib. task analysis, the identification and evaluation of the cognitive and motor steps required to accomplish a specific action. task functions, behaviors that focus or direct activities toward ...

Google previewEncyclopedia of Molecular Pharmacology

by Stefan Offermanns

Imatinib resistance in CML and ALL is addressed by second generation c-Abl inhibitors like nilotinib (AMN-107, Tasigna) and dasatinib (BMS-354825, Sprycel) . Imatinib is also used for the treatment of gastrointestinal stroma tumors (GIST), ...

Google previewMosby's Dictionary of Medicine, Nursing & Health Professions (2016)

by Mosby

Tasigna, a chemotherapeutic agent. Brand name for nilotinib. task analysis, the identification and evaluation of the cognitive and motor steps required to accomplish a specific action. task functions, behaviors that focus or direct activities toward ...

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Scrabble value of T1A1S1I1G2N1A1

The value of this 7-letter word is 8 points, but it's not an accepted word in the Official Scrabble Players Dictionary.

Anagrams of TASIGNA

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