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72 examples:

One area of specific focus is that of Anti-Money Laundering (AML).
(Forbes - Technology, )

This analysis overviews the late-stage AML pipeline and the changing AML market.
(Nature Reviews Drug Discovery, )

AML occurs mainly in older patients and has a three-year survival rate of 5 to 15 percent.
(Science Daily - News, )

Acute myeloid leukemia (AML) refers to a group of disorders that are also known as blood cancer.
(Science Daily - News, )

Despite improved therapy, only one out of every two adult patients survive acute myeloid leukemia (AML).
(Science Daily - News, )

Researchers have developed an automated 'debugging' approach called Adaptive Multimodal Bug Localisation (AML).
(Science Daily - News, )

The mechanism that gene MN1 uses to cause an aggressive AML subtype is better understood thanks to new research.
(Science Daily - News, )

The management of acute myeloid leukaemia (AML) in young adult patients has not changed much over the past 30 years.
(Nature Reviews Clinical Oncology, )

Acute myeloid leukaemia (AML) is a heterogeneous disease that is, in general, associated with a very poor prognosis.
(Nature Reviews Clinical Oncology, )

A promising new approach to the treatment of acute myeloid leukemia (AML) has been discovered by a team of researchers.
(Science Daily - News, )

Acute myeloid leukemia (AML) is actually an umbrella term for 11 distinct subtypes of the illness, new research has revealed.
(Tech Times - Health, )

The authors suggest the research may point to new paradigms in both the diagnosis and treatment of aggressive cancers, like AML.
(Science Daily - News, )

STAT3 is a transcription factor involved in cell survival and immunosuppression, and is implicated in acute myeloid leukaemia (AML).
(Nature Reviews Clinical Oncology, )

Ansley Riedel was just 10 months old when she was diagnosed with acute myeloid leukemia (AML) – a cancer of the blood and bone marrow.
(Fox News - Health, )

AML is an aggressive disease of malignant immature blood cells which, if left untreated, almost always causes the death of the affected patient.
(Science Daily - News, )

Gentner et al. identified a prognostic microRNA (miRNA) signature from leukaemia stem cells (LSCs) in human acute myeloid leukaemia (AML) samples.
(Nature Reviews Cancer, )

Here, the authors report frequent CDC25C mutations in FPD/AML patients and suggest that this gene may influence malignant transformation in FPD/AML.
(Nature Communications, )

Responses of acute myeloid leukaemia (AML) patients to cytarabine (Ara-C)-based therapies are often short lived with a median overall survival of months.
(Nature, )

In a Phase II clinical trial in poor prognosis AML, ribavirin monotherapy yielded promising responses including remissions; however, all patients relapsed.
(Nature, )

Lechman, Gentner et al. identified a prognostic microRNA (miRNA) signature from leukaemia stem cells (LSCs) in human acute myeloid leukaemia (AML) samples.
(Nature Reviews Cancer, )

The study demonstrates the validity of using approximate maximum likelihood (AML) algorithms to determine the direction of arrival (DOA) of birdsong sources.
(Science Daily - News, )

AML gleans debugging hints from both bug reports and test cases, and it performs a statistical analysis to pinpoint program elements that are likely to contain bugs.
(Science Daily - News, )

A mechanism that enables the development of resistance to Acute Myeloid Leukemia (AML) anticancer drugs, thereby leading to relapse, has been identified by researchers.
(Science Daily - News, )

Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to researchers.
(Science Daily - News, )

The standard of care for the treatment of acute myeloid leukaemia (AML) has changed little for decades, but there are now a number of interesting agents in development.
(Nature Reviews Drug Discovery, )

Multiple cytogenetic and molecular abnormalities that characterize different forms of AML have been used to better prognosticate patients and inform treatment decisions.
(Nature Reviews Clinical Oncology, )

New interactions between two molecules involved in acute myeloid leukemia (AML) have been found by scientists that may offer a new therapeutic target for cancer treatment.
(Science Daily - News, )

Scientists have identified a gene -- FOXC1 -- that, if switched on, causes more aggressive cancer in a fifth of acute myeloid leukemia (AML) patients, according to a study.
(Science Daily - News, )

Novartis' Midostaurin showed promising results in the survival rate of patients diagnosed with AML. Also known as PKC412, the drug will be set for regulatory submissions by 2016.
(Tech Times - Health, )

Three papers now present different aspects of a similar story: altered splicing can lead to myelodysplastic syndrome (MDS) and even to progression to acute myeloid leukaemia (AML).
(Nature Reviews Cancer, )

Familial platelet disorder with predisposition to acute myelogenous leukaemia (FPD/AML) is characterized by abnormal platelet function and a high risk of haematological malignancies.
(Nature Communications, )

In AML cells, CA upregulated SE-associated genes with tumour suppressor and lineage-controlling functions, including the transcription factors CEBPA, IRF8, IRF1 and ETV6 (refs 8).
(Nature, )

A new study provides a rationale for the use of poly (ADP-ribose) polymerase (PARP) inhibitors to trigger irreparable DNA damage as a therapeutic approach in acute myeloid leukemia (AML).
(Nature Medicine, )

The new discovery constitutes a major breakthrough in the fight against AML, one of the deadliest forms of leukemia, because it immediately suggests strategies to overcome drug resistance.
(Science Daily - News, )

Here we show that the Mediator-associated kinases cyclin-dependent kinase 8 (CDK8) and CDK19 restrain increased activation of key SE-associated genes in acute myeloid leukaemia (AML) cells.
(Nature, )

Patients with relapsed and/or refractory acute myeloid leukaemia (AML) have a poor prognosis; allogeneic stem-cell transplantation is potentially curative, but many patients are ineligible.
(Nature Reviews Clinical Oncology, )

However, as has been recently discovered, these cells do have a weakness: the enzyme 5-lipoxygenase (5-LO) plays a significant role in the survival of leukaemic AML stem cells, it turns out.
(Science Daily - News, )

Point mutations of the isocitrate dehydrogenases IDH1 and IDH2, found in acute myeloid leukaemia (AML), promote a block in cellular differentiation that is due to global DNA hypermethylation.
(Nature Reviews Drug Discovery, )

Our results demonstrate that Mediator kinases can negatively regulate SE-associated gene expression in specific cell types, and can be pharmacologically targeted as a therapeutic approach to AML.
(Nature, )

Combining the drug gemtuzumab ozogamicin (GO) with conventional chemotherapy may improve the outcome of bone marrow transplantation for some children battling high-risk acute myeloid leukemia (AML).
(Science Daily - News, )

Individually increasing or decreasing the expression of these transcription factors suppressed AML cell growth, providing evidence that leukaemia cells are sensitive to the dosage of SE-associated genes.
(Nature, )

At the EORTC–NCI–AACR (ENA) Symposium in Barcelona, promising data for AG-120, an oral inhibitor of the mutated IDH1 gene product, was presented in patients with advanced-stage acute myeloid leukaemia (AML).
(Nature Reviews Clinical Oncology, )

There are several features that distinguish t-AML from de novo AML, including a higher incidence of TP53 mutations, abnormalities of chromosomes 5 or 7, complex cytogenetics and a reduced response to chemotherapy.
(Nature, )

In new research, investigators describe compulsive evolution and dramatic genetic diversity in cells belonging to one of the most treatment-resistant and lethal forms of blood cancer: acute myeloid leukemia (AML).
(Science Daily - News, )

A moving photographic juxtaposition of a boy named Noah depicting him as an AML patient and later as a survivor is the centrepiece of a new campaign called 'My Life is Proof' promoting the Children’s Cancer Center.
(Daily Mail - Health, )

A new study shows "extremely promising” early phase 1 clinical trial results for the investigational drug AG-120 against the subset of patients with acute myeloid leukemia (AML) harboring mutations in the gene IDH.
(Science Daily - News, )

Cancer researchers have discovered a pre-leukemic stem cell that may be the first step in initiating disease and also the culprit that evades therapy and triggers relapse in patients with acute myeloid leukemia (AML).
(Science Daily - News, )

Here, the authors show that mir-22 functions as a tumour suppressor in de novo acute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.
(Nature Communications, )

Here the authors show that these cells have elevated GSK3β, and that its inhibition prolongs survival of mice transplanted with human AML and stimulates NK cytotoxicity via increased adhesion of NK cells to their targets.
(Nature Communications, )

The chemotherapy treatments necessary to treat Acute Myeloid Leukemia (AML) in children can be grueling on the body, and can cause health-related complications during therapy, as well as long down the road after remission.
(Science Daily - News, )

AML is a devastating disease and proves fatal within five years for 90 per cent of seniors over age 65. This new avocado-derived drug could one day significantly increase life expectancy and quality of life for AML patients.
(Science Daily - News, )

A new study provides the first insights into epigenetic heterogeneity in AML. The study highlights a striking independence of genetic and epigenetic variation, and links the kinetics of epigenetic change to clinical outcome.
(Nature Medicine, )

A number of highly recurrent mutations associated with acute myeloid leukaemia (AML) have been identified using genomic approaches, but a link between mutations detected at diagnosis and disease outcome has so far not been found.
(Nature Reviews Clinical Oncology, )

Following the discovery of BRD4 as a non-oncogene addiction target in acute myeloid leukaemia (AML), bromodomain and extra terminal protein (BET) inhibitors are being explored as a promising therapeutic avenue in numerous cancers.
(Nature, )

Here, the authors demonstrate that the cell of origin determines the aggressiveness of AML in a mouse model and identify unique biomarkers of the specific leukaemia cell of origin by profiling open chromatin regions of AML samples.
(Nature Communications, )

Approximately 25% of patients with acute myelogenous leukaemia (AML) also have internal tandem duplication of the FLT3 gene (FLT3–ITD); these patients typically have shorter overall survival compared with those who lack this aberration.
(Nature Reviews Clinical Oncology, )

Children receiving chemotherapy for AML receive 4 to 5 intensive chemotherapy courses, and while some children recover quickly from each course, others may take several months or more, which increases their risk for life-threatening infections.
(Science Daily - News, )

A protein-coding gene called hnRNP K has been identified as a tumor suppressor for acute myeloid leukemia (AML), a finding that could be important for investigating how best to target treatment of a blood cancer striking mostly older individuals.
(Science Daily - News, )

Cancer researchers led by stem cell scientist Dr. John Dick have discovered a pre-leukemic stem cell that may be the first step in initiating disease and also the culprit that evades therapy and triggers relapse in patients with acute myeloid leukemia (AML).
(Science Daily - News, )

Researchers have identified a set of genes, including DNMT3A, that could potentially be used to predict clinical outcomes of patients who suffer from a type of Acute Myeloid Leukemia (AML) associated with an FLT3 internal tandem duplication (FLT3-ITD) mutation.
(Science Daily - News, )

We report that the natural product cortistatin A (CA) selectively inhibits Mediator kinases, has anti-leukaemic activity in vitro and in vivo, and disproportionately induces upregulation of SE-associated genes in CA-sensitive AML cell lines but not in CA-insensitive cell lines.
(Nature, )

New data from a next-generation-sequencing study of 15 patients with acute myelogenous leukaemia (AML) has revealed that a subset of patients with clearance of the founding AML clone after induction chemotherapy also develop expansion of a genetically unrelated population of clones.
(Nature Reviews Clinical Oncology, )

To identify factors involved in primary and acquired BET resistance in leukaemia, here we perform a chromatin-focused RNAi screen in a sensitive MLL–AF9;NrasG12D-driven AML mouse model, and investigate dynamic transcriptional profiles in sensitive and resistant mouse and human leukaemias.
(Nature, )

Genome sequencing of therapy-related acute myeloid leukaemia (t-AML) has revealed that these malignancies do not have more mutations than de novo AML, and that TP53 mutations, which are common in t-AML, are likely to be present before treatment with chemotherapy and expand following treatment.
(Nature Reviews Cancer, )

In their report, the investigators have identified a crucial dysfunction in blood cell development that underlies AML and show that inhibiting the action of a specific enzyme prompts the differentiation of leukemic cells, reducing their number and decreasing their ability to propagate the cancer.
(Science Daily - News, )

Here, by sequencing the genomes of 22 patients with t-AML, we show that the total number of somatic single-nucleotide variants and the percentage of chemotherapy-related transversions are similar in t-AML and de novo AML, indicating that previous chemotherapy does not induce genome-wide DNA damage.
(Nature, )

Patients whose acute myelogenous leukemia (AML) had relapsed or was resistant to chemotherapy and those who were deemed unable to tolerate chemotherapy experienced responses to the selective BCL-2 inhibitor venetoclax (Venclexta), with complete remissions in some, according to phase II clinical trial data.
(Science Daily - News, )

In two separate studies on CEBPA mutations in acute myeloid leukemia (AML) subtypes, researchers successfully identified and validated a gene known as Sox4 as a potential therapeutic target and a class of anti-cancer drugs, histone deacetylase inhibitors, as potential candidates in the treatment of certain AML.
(Science Daily - News, )

For many institutions, there are several challenges to creating a sustainable AML organization – one that can respond to regulatory reporting mandates and provide information to support “business as usual” demands – while also finding, developing and retaining the talent needed to accomplish these critical activities.
(Forbes - Technology, )

Using genetic profiling to study bone marrow samples from patients with acute myeloid leukemia (AML), researchers found that those whose cells still carried mutations 30 days after the initiation of chemotherapy were about three times more likely to relapse and die than patients whose bone marrow was cleared of these mutations.
(Science Daily - News, )

Our screen shows that suppression of the PRC2 complex, contrary to effects in other contexts, promotes BET inhibitor resistance in AML. PRC2 suppression does not directly affect the regulation of Brd4-dependent transcripts, but facilitates the remodelling of regulatory pathways that restore the transcription of key targets such as Myc.
(Nature, )

Melbourne researchers have showed that they can stop leukemia in its tracks by targeting a protein that puts the handbrake on cancer cell growth.The researchers discovered that targeting a protein called Hhex could cure acute myeloid leukemia (AML) in preclinical disease models, and could be a key target for new therapies for human leukemia.
(Science Daily - News, )

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