Examples of Axin
Disruption of the RNF146–TNKS interaction inhibits turnover of the substrate Axin in cells.
Recent studies have shown that PARylation can serve as a signal for the polyubiquitination and degradation of several crucial regulatory proteins, including Axin and 3BP2 (refs 9).
Cancer-associated point mutations in the scaffold protein Axin derail Wnt signaling and promote tumor growth through formation of nonamyloid nanoaggregates that rewire the Axin interactome.
(Nature Structural & Molecular Biology, )
Here the authors implicate Tankyrase—previously shown to target the scaffolding protein Axin for proteolysis—in early Wnt signalling by promoting the interaction between Axin and the Wnt co-receptor LRP6.
(Nature Communications, )
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