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Examples of Abasic


4 examples:

DNA pairing defects such as mismatched and abasic DNA are prevalent in cancer cells.
(Nature Communications, )

Now, structural and kinetic analyses reveal that NER enzymes DNA polymerase β and FEN1 can also excise these adducts and thus provide a 'backup' repair pathway for abasic sites.
(Nature Structural & Molecular Biology, )

Here, Lee et al. report that substituting nucleotide in position 6 of the seed region of the small interfering RNAs with abasic spacers can significantly decrease miRNA-like off-target repression while preserving on-target activity.
(Nature Communications, )

During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair.
(Nature Structural & Molecular Biology, )

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