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Examples of Aberrations

Sentence with the noun Aberrations

1 example:

This is the curse of our age, even the strangest aberrations are no cure for boredom.
(Stendhal)

Other sentences

43 examples:

Of all the sexual aberrations, chastity is the strangest.
(Anatole France)

Of all the sexual aberrations, perhaps the most peculiar is chastity.
(Remy de Gourmont)

Aberrations on the skin are nothing to fool around with.
(NBC Today, )

Diabetes is associated with aberrations in glucose metabolism.
(Nature Communications, )

Targeted cancer therapy requires knowledge of driver aberrations.
(Nature Communications, )

Chromosomal aberrations can be detected by global gene expression analysis.
(Nature Communications, )

Multipolar spindles are a feature of cancer cells often associated with chromosomal aberrations.
(Nature Cell Biology, )

Over a century ago, centrosome aberrations were postulated to cause cancer by promoting genome instability.
(Nature Reviews Cancer, )

Wiesner et al. report a mechanism of oncogene activation that is independent of somatic genetic aberrations.
(Nature Reviews Cancer, )

In fact, it is among the most frequent chromosomal aberrations seen in many cancers, including ovarian and breast cancers.
(Science Daily - News, )

Direct wavefront sensing with laser ‘guide stars’ is used in astronomy and microscopy to correct for optical aberrations.
(Nature Communications, )

Ring chromosomes are structural aberrations commonly associated with birth defects, mental disabilities and growth retardation.
(Nature, )

Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined.
(Nature, )

These aberrations result from stressors in the intrauterine environment (maternal smoking, diet, or high levels of endocrine-disrupting chemicals).
(Science Daily - News, )

Here the authors analyse DNA copy number aberrations in primary tumours from CRC patients and identify genetic variants that influence drug response.
(Nature Communications, )

Dewhurst et al. examined the evolution and consequences of chromosomal aberrations using long-term culture of a diploid colon cancer progenitor cell line.
(Nature Reviews Cancer, )

As with most cancers, triple-negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes.
(Science Daily - News, )

Now a multi-institutional research team has identified a family of enzymes they say is crucial for the growth of cancers that have genetic aberrations in p53.
(Science Daily - News, )

The Pan-Cancer Initiative, a major effort to analyze the molecular aberrations in cancer cells across a range of tumor types, has yielded an abundance of new findings.
(Science Daily - News, )

Dewhurst and colleagues examined the evolution and consequences of chromosomal aberrations in long-term culture of a diploid colon cancer progenitor cell line over time.
(Nature Reviews Genetics, )

Owing to the severity of these large aberrations that can affect multiple contiguous genes, no possible therapeutic strategies for ring chromosome disorders have been proposed.
(Nature, )

Molecular aberrations in men with advanced-stage disease have been associated with sensitivity to platinum-based chemotherapy and poly(ADP-ribose) polymerase-1 (PARP) inhibitors.
(Nature Reviews Urology, )

Zhu et al. identified mutations in the histone-lysine N-methyltransferase SETD2 and showed that these mutations cooperate with other genetic aberrations to promote acute leukaemia.
(Nature Reviews Cancer, )

Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders with diverse phenotypes and can derive from hematopietic stem cells after the acquisition of specific somatic aberrations.
(Nature Communications, )

Here, the authors carry out genome and transcriptome sequencing of clear cell renal cell carcinomas (ccRCCs) and highlight genomic aberrations and biological pathways underlying ccRCC tumorigenesis.
(Nature Communications, )

A phase II trial has investigated ibrutinib monotherapy in patients with chronic lymphocytic leukaemia (CLL) harbouring TP53 aberrations, who often have a poor response to first-line chemoimmunotherapy.
(Nature Reviews Clinical Oncology, )

Here, the authors use gene expression profiles to generate a catalogue of copy number aberrations in 45 mouse models, and compare mouse and human tumours to identify additional drivers of tumorigenesis.
(Nature Communications, )

The "virtuous" origin of derivatives as a means to protect, say, farmers from weather aberrations, has morphed into something dangerous and harmful to Wall Street investors, and by contagion, Main Street.
(Forbes - Education, )

Here, the authors report eSNP-Karyotyping, a new method that can detect chromosomal aberrations by measuring the ratio of expression between the two alleles without comparison to a matched diploid sample.
(Nature Communications, )

ALKATI is expressed from both ALK alleles, and no recurrent genetic aberrations are found at the ALK locus, indicating that the transcriptional activation is independent of genetic aberrations at the ALK locus.
(Nature, )

Many cancers harbour deficiencies in DNA double-strand break (DSB) repair; in particular, aberrations affecting components of the homologous recombination (HR) pathway, such as BRCA1 and BRCA2, and ATM, are common.
(Nature Reviews Clinical Oncology, )

With improved knowledge of protein activity, scientists can better understand not only basic biology but also how disease corrupts cellular function and identify potential therapeutics to rectify these aberrations.
(Science Daily - News, )

Benjamin Raphael and colleagues report an analysis of altered subnetworks of somatic aberrations in TCGA pan-cancer data sets, including 3,281 samples from 12 cancer types, using a newly developed HotNet2 algorithm.
(Nature Genetics, )

The latest sequencing and analysis methods have successfully identified somatic alterations, including single-nucleotide variants, insertions and deletions, copy-number aberrations, structural variants and gene fusions.
(Nature Reviews Genetics, )

This study identifies many new alterations, confirms genetic differences in these distinct subtypes of biliary tract cancer and demonstrates that approximately 40% of described genetic aberrations are potentially targetable.
(Nature Genetics, )

Prognostic and/or predictive genetic aberrations in haematological malignancies include nucleotide substitutions, insertions and deletions, copy-number alterations, and rearrangements that result in oncogene fusion or overexpression.
(Nature Reviews Clinical Oncology, )

Our results suggest a fundamentally different function for cellular reprogramming as a means of ‘chromosome therapy’ to reverse combined loss-of-function across many genes in cells with large-scale aberrations involving ring structures.
(Nature, )

Liquid biopsies — such as the sequencing-based analysis of cell-free DNA (cfDNA) circulating in blood — have garnered increasing interest in oncology as a minimally invasive method to obtain information on cancer-associated genetic and epigenetic aberrations.
(Nature Reviews Genetics, )

DNA methylation patterns are disrupted in various malignancies, suggesting a role in the development of cancer, but genetic aberrations directly linking the DNA methylation machinery to malignancies were rarely observed, so this association remained largely correlative.
(Nature Reviews Cancer, )

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are often caused by genetic defects that result in functional deregulation of epigenetic proteins, their altered expression and/or their atypical recruitment to certain gene promoters.
(Nature Reviews Drug Discovery, )

To test the optical performance and components of the beamline, the scientists put a material in the path of the x-ray beam and attempted to characterize its structure as the best way to identify and fix possible flaws or aberrations that the instrument could have caused.
(Science Daily - News, )

A new study based on single-nucleus sequencing reports that triple-negative breast cancers acquire copy number aberrations in short punctuated bursts in the earliest stages of tumor evolution, rather than continuously and gradually, challenging prevailing models of tumor evolution.
(Nature Genetics, )

Moreover, we have found that several important histone regulator genes (MLL2 (also called KMT2D), ASH1L, MLL3 (KMT2C), SETD1B, CREBBP and EP300) are frequently altered in ESCC. Pathway assessment reveals that somatic aberrations are mainly involved in the Wnt, cell cycle and Notch pathways.
(Nature, )

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