Examples of Abrogated
Sentence with the verb Abrogated
This repopulation can be abrogated by a PGE2-neutralizing antibody and celecoxib drug-mediated blockade of PGE2 signalling.
In addition, treatment on day 3 abrogated the induction of SIV-specific humoral and cellular immune responses.
Alcolea and colleagues used lineage tracing to track oesophageal epithelial progenitor cells in which Notch signalling is abrogated.
(Nature Reviews Cancer, )
Missense mutations in p53 generate aberrant proteins with abrogated tumour suppressor functions that can also acquire oncogenic gain-of-function activities that promote malignant progression, invasion, metastasis and chemoresistance.
Administration of the docosanoid resolution mediator, protectin DX (PDX), to obese diabetic mice resulted in release of IL-6 from skeletal muscle, which abrogated hepatic gluconeogenesis via Stat3-dependent transcriptional suppression.
(Nature Reviews Endocrinology, )
By contrast with MDV3100, JQ1 functions downstream of AR, and more potently abrogated BRD4 localization to AR target loci and AR-mediated gene transcription, including induction of the TMPRSS2-ERG gene fusion and its oncogenic activity.
Antisense oligonucleotide knockdown of hepatic mitochondrial glycerophosphate dehydrogenase in rats resulted in a phenotype akin to chronic metformin treatment, and abrogated metformin-mediated increases in cytosolic redox state, decreases in plasma glucose concentrations, and inhibition of endogenous glucose production.
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