Examples of Abrogated
Sentence with the verb Abrogated
This repopulation can be abrogated by a PGE2-neutralizing antibody and celecoxib drug-mediated blockade of PGE2 signalling.
In addition, treatment on day 3 abrogated the induction of SIV-specific humoral and cellular immune responses.
DENV replication was nearly completely abrogated in cells deficient in the oligosaccharyltransferase (OST) complex.
Alcolea and colleagues used lineage tracing to track oesophageal epithelial progenitor cells in which Notch signalling is abrogated.
(Nature Reviews Cancer, )
In the absence of NEK7, caspase-1 activation and IL-1β release were abrogated in response to signals that activate NLRP3, but not NLRC4 or AIM2 inflammasomes.
Pou2f3−/− mice lack intestinal tuft cells and have defective mucosal type 2 responses to helminth infection; goblet cell hyperplasia is abrogated and worm expulsion is compromised.
Missense mutations in p53 generate aberrant proteins with abrogated tumour suppressor functions that can also acquire oncogenic gain-of-function activities that promote malignant progression, invasion, metastasis and chemoresistance.
Administration of the docosanoid resolution mediator, protectin DX (PDX), to obese diabetic mice resulted in release of IL-6 from skeletal muscle, which abrogated hepatic gluconeogenesis via Stat3-dependent transcriptional suppression.
(Nature Reviews Endocrinology, )
By contrast with MDV3100, JQ1 functions downstream of AR, and more potently abrogated BRD4 localization to AR target loci and AR-mediated gene transcription, including induction of the TMPRSS2-ERG gene fusion and its oncogenic activity.
Seokho et al. report that Wnt ligands bind the extracellular domain of polycystin 1 (PKD1) and induce Ca2+ influx through the Ca2+-permeable ion channel TRPP2. This activity is abrogated by PKD1 mutations linked to polycystic kidney disease.
(Nature Cell Biology, )
Antisense oligonucleotide knockdown of hepatic mitochondrial glycerophosphate dehydrogenase in rats resulted in a phenotype akin to chronic metformin treatment, and abrogated metformin-mediated increases in cytosolic redox state, decreases in plasma glucose concentrations, and inhibition of endogenous glucose production.
Activated macrophages formed a high-molecular-mass NLRP3–NEK7 complex, which, along with ASC oligomerization and ASC speck formation, was abrogated in the absence of NEK7. NEK7 was required for macrophages containing the CAPS-associated NLRP3(R258W) activating mutation to activate caspase-1. Mouse chimaeras reconstituted with wild-type, Nek7−/− or Nlrp3−/− haematopoietic cells showed that NEK7 was required for NLRP3 inflammasome activation in vivo.
See also examples for abrogate.
Don't miss the pronunciation examples of Abrogated to learn how to say it correctly!
Share this page
Go to the pronunciation of Abrogated to learn how to say it correctly!