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Header of Acetylation

Examples of Acetylation

Sentences

40 examples:

N-terminal acetylation is a common protein modification in eukaryotes.
(Nature Communications, )

Tumour suppressor activity of p53 has been suggested to rely on acetylation of its C terminus.
(Nature Communications, )

Pharmacological inhibition of tau acetylation ameliorates these phenotypes in a mouse model of AD.
(Nature Medicine, )

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility.
(Nature Reviews Endocrinology, )

The importance of the post-translational modification by acetylation in regulating protein function is not fully understood.
(Nature Communications, )

Through a cell-based high-throughput chemical screen, we identify a Cdk4 inhibitor that potently decreases PGC-1α acetylation.
(Nature, )

Post-translational acetylation of TDP-43 promotes accumulation of insoluble, hyperphosphorylated TDP-43, according to a new study.
(Nature Reviews Neurology, )

Histone acetylation has been proposed to be crucial for the regulation of gene transcription controlled by the plant hormone auxin.
(Nature Communications, )

Here the authors demonstrate that MAT IIα stability is regulated by acetylation and this regulation is important for tumour growth.
(Nature Communications, )

Histone modifications alter the cellular transcriptional profile, and dysregulation of histone acetylation frequently occurs in cancer.
(Nature Reviews Drug Discovery, )

Comprehensive analysis of changes in protein acetylation in response to lysine deacetylase inhibitors uncovers inhibitor specificities.
(Nature Biotechnology, )

Lysine acetylation is a conserved protein post-translational modification that links acetyl-coenzyme A metabolism and cellular signalling.
(Nature Reviews Molecular Cell Biology, )

The role of known histone modifications, such as Lys acetylation and methylation, in transcriptional control and epigenetics is well-established.
(Nature Reviews Molecular Cell Biology, )

Here, the authors show that the bZIP11 transcription factor activates auxin-mediated transcription by recruiting the histone acetylation machinery.
(Nature Communications, )

It has recently been shown that acetylation of soluble tau oligomers is increased in the brains of people with mild-to-moderate Alzheimer disease (AD).
(Nature Reviews Neuroscience, )

Here the authors describe a method to uncover patterns of site-specific histone acetylation by deconvolution of overlapping peptide isomer mass spectra.
(Nature Communications, )

Here, the authors show that α-tubulin acetylation regulates p38 kinase signalling and expression of the anti-inflammatory cytokine IL-10 in macrophages.
(Nature Communications, )

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the development of several diseases.
(Nature Reviews Drug Discovery, )

Acetylation of tau at K174 is identified in Alzheimer's disease (AD) brain tissue and exacerbates tau-mediated neurodegeneration and memory impairments in mice.
(Nature Medicine, )

α-tubulin acetylation is an evolutionarily conserved modification but despite its prevalence, the physiological function of this process remains poorly understood.
(Nature Communications, )

First acetylation enhances the search kinetics of transcriptional activators, and later the acetylation accelerates the transition of RNAP2 from initiation to elongation.
(Nature, )

In this Focus review Mowen and David describe the key 'non-conventional' modifications such as acetylation and nitrosylation that affect immunologically-relevant proteins.
(Nature Immunology, )

Here the authors show that Brd1 epigenetically marks CD8 enhancer for activation by mediating H3K14 acetylation, which is necessary for establishing the CD8 T-cell lineage.
(Nature Communications, )

Acetylation at C13 before C8 hydroxylation introduces a protective group subsequently hydrolyzed by a carboxylesterase, which triggers rearrangement to a cyclic hemiacetal.
(Nature Chemical Biology , )

Here, the authors show that acetylation of the transcriptional factor PLZF promotes the assembly of a repressor complex that limits the inflammatory response mediated by NF-κB.
(Nature Communications, )

New data show that it can also stimulate transcription by cooperating with PARP-1 to promote CBP-mediated H2B acetylation and that this regulatory function is lost in cancer cells.
(Nature Structural & Molecular Biology, )

They report that histone methylation or acetylation at the FosB locus in nucleus accumbens is sufficient to control drug- and stress-evoked transcriptional and behavioral responses.
(Nature Neuroscience, )

Our single-cell analysis reveals histone H3 lysine-27 acetylation at a gene locus can alter downstream transcription kinetics by as much as 50%, affecting two temporally separate events.
(Nature, )

New work shows that PARP1 and CBP can be displaced from chromatin in cancer cells that have lost macroH2A.1.1, thus leading to changes in histone H2B acetylation at cancer-relevant genes.
(Nature Structural & Molecular Biology, )

Here, Cohen et al . discover lysine acetylation as a modification that regulates TDP-43 function, providing a mechanism that could be implicated in the pathogenesis of TDP-43 proteinopathies.
(Nature Communications, )

Here Sun et al. show that Beclin 1 acetylation regulated by p300 and SIRT1 inhibits autophagosome maturation, and mutation of the acetylation sites leads to tumour growth suppression in vivo.
(Nature Communications, )

Here the authors show that the virus in the EGFR-dependent manner induces IFRD1, which blocks NFκB activating acetylation, and that this process can be suppressed by the EGFR inhibitor cetuximab.
(Nature Communications, )

In 1964, Vincent Allfrey and colleagues reported the identification of histone acetylation and with deep insight proposed a regulatory role for this protein modification in transcription regulation.
(Nature Reviews Molecular Cell Biology, )

Here the authors solve the structure of a DNMT1-USP7 complex and demonstrate the mechanism by which DNMT1 stability is regulated through acetylation by preventing association with the deubiquitinase USP7.
(Nature Communications, )

Here Wang and colleagues show that the Rho GTPase-activating protein ArhGAP30 is required for P300-mediated p53 acetylation and functional activation in colorectal cancer, and identify ArhGAP30 as a potential prognostic marker.
(Nature Communications, )

Godena et al. find that disease-associated LRRK2 mutations promote its binding to deacetylated microtubules, and cause defects in axonal transport and Drosophila locomotor behaviour that can be reversed by enhancing tubulin acetylation.
(Nature Communications, )

Here the authors show that in Arabidopsis, N-terminal acetylation is decreased by drought stress, that abundance of an N-terminal acetyltransferase is reduced by abscisic acid and that constitutive downregulation can confer drought resistance.
(Nature Communications, )

Starting with early work on histone acetylation, a variety of residue-specific modifications have now been linked to RNA polymerase II (RNAP2) activity, but it remains unclear if these markers are active regulators of transcription or just passive byproducts.
(Nature, )

The combination of deep chromatin immunoprecipitation–sequencing with a statistical test that scores the correlation of peak height and allelic imbalance allows de novo discovery of histone acetylation quantitative trait loci without prior genotyping or genome sequencing.
(Nature Methods, )

While N-terminal acetylation has been shown to regulate the function or stability of a limited number of specific proteins, Holmes et al. report that global loss of this modification results in widespread protein misfolding, and show that the resulting stress response contributes to the suppression of a yeast prion phenotype.
(Nature Communications, )

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