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Examples of Active site

Sentences with the noun Active site

17 examples:

Here we present a 2.1 Å co-crystal structure of resveratrol bound to the active site of TyrRS.
(Nature, )

The active site of many non-noble metal cathodic oxygen reduction catalysts consists of a nitrogen-corodinated transition metal.
(Nature Communications, )

The CO 2 -fixing enzyme rubisco requires motor proteins known as rubisco activases to remove inhibitors bound to its active site.
(Nature Communications, )

Goldfeder et al. present tyrosinase crystal structures and reveal that both of its substrates orient identically in the active site.
(Nature Communications, )

Enzymatic catalysis relies on stereoelectronic complementarity between the enzyme's active site and the substrate's transition state.
(Nature Chemistry, )

Fluorescent probes at the exit channel and near the active site of RNA polymerase shed light on how transcriptional pausing is regulated.
(Nature Structural & Molecular Biology, )

Here, the authors have designed pre-substrates to release fluorescent signals whenever a nucleophile fragment binds next to the active site of the enzyme.
(Nature Communications, )

Here the authors show that plasma-activated copper can catalyse the reduction of carbon dioxide to ethylene with high efficiency and reveal cationic copper as the active site.
(Nature Communications, )

Now crystal structures of BcsA–BcsB along with functional analysis reveal that binding of c-di-GMP releases a conserved gating loop to allow substrate to enter the active site.
(Nature Structural & Molecular Biology, )

Our work highlights the plasticity of deubiquitinases and indicates that new conformational states can occur when a true substrate, such as diubiquitin, is bound at the active site.
(Nature, )

Researchers have demonstrated that even when certain amino acids are far from the active site of an enzyme, a change in their flexibility and atomic fluctuations can significantly impact enzyme activity.
(Science Daily - News, )

The identification of the active site of an iron-containing catalyst raises hopes of designing practically useful catalysts for the room-temperature conversion of methane to methanol, a potential fuel for vehicles.
(Nature, )

The ACP domain is differentially and precisely positioned after polyketide chain substrate loading on the active site of the ketosynthase, after extension to the β-keto intermediate, and after β-hydroxy product generation.
(Nature, )

NEK7, a kinase involved in mitosis, is regulated by the kinase NEK9. Here the authors identify the region in NEK9 that binds NEK7 and find that the mechanism of regulation involves dimerization coupled to structural changes in the active site.
(Nature Communications, )

The crystal structure implies a two-step mechanism for hydrazine synthesis: a three-electron reduction of nitric oxide to hydroxylamine at the active site of the γ-subunit and its subsequent condensation with ammonia, yielding hydrazine in the active centre of the α-subunit.
(Nature, )

Reactivity occurs at an extra-lattice active site called α-Fe(ii), which is activated by nitrous oxide to form the reactive intermediate α-O; however, despite nearly three decades of research, the nature of the active site and the factors determining its exceptional reactivity are unclear.
(Nature, )

Complexes with tethered amines that resemble the active site of hydrogenases have been shown both to catalyse hydrogen production (from protons and electrons) with rates far exceeding those of such enzymes and to mediate reversible electrocatalytic hydrogen production and oxidation with enzyme-like performance.
(Nature, )

Other sentences

38 examples:

A third metal ion enters the active site and has a key role in hydrolysis.
(Nature Structural & Molecular Biology, )

This flexibility of the active site prevents irreversible oxidative damage.
(Nature Chemistry, )

Simulations also show that although Ca2+ drives folding it leaves the active site unstable.
(Nature Chemistry, )

Catalysts that contain two types of active site split long hydrocarbon molecules into more-useful shorter ones.
(Nature, )

Here, the authors review the raft of techniques applied to characterize their crystal, pore and active site structures.
(Nature Communications, )

In enzyme-catalysed metabolic pathways, substrate channelling often directs the movement of intermediates from one active site to the next.
(Nature Chemistry, )

Here, the authors use structural biology and biochemistry to investigate the role of proteasome active site residues on maturation and activity.
(Nature Communications, )

Here, Leferink et al. show that mutation of residues in copper nitrate reductase that are 12Å away from the active site perturb enzyme function.
(Nature Communications, )

Here, the authors identify important arrangements of active site residues and use structural bioinformatics to successfully predict enzyme activity.
(Nature Communications, )

Site-directed mutagenesis studies confirmed the active site resi-dues essential for activity, and we found that BpHep has specificity for heparan sulfate.
(Nature Chemical Biology , )

However, these effects take place through different mechanisms: GTP directly extends loops around the active site, whereas taxol works like a remote lever.
(Nature Structural & Molecular Biology, )

Protein crystallography confirms that the active site geometry of the redesigned dehalogenase matches that of the target, but its enantioselectivity remains low.
(Nature Chemical Biology , )

A hallmark of these and other DNA repair enzymes is their use of base flipping to sequester modified nucleotides from the DNA helix and into an active site pocket.
(Nature, )

The stereochemical outcome of enzyme-catalysed reactions with physiological substrates is typically governed by the well-defined geometry of the enzyme active site.
(Nature Chemistry, )

Now, a NiFe model complex has been reported that mimics the structure and the Ni-centred hydrogen evolution activity found at the active site of
(Nature Chemistry, )

The active site environment is dominated by π systems, which assist phosphate-C1′ bond breakage following FMN reduction, leading to formation of the N5–C1′ bond.
(Nature, )

Rumpf et al. present structures of human Sirt2 in complex with two highly selective drug-like inhibitors, and show that they act by rearranging the enzyme’s active site.
(Nature Communications, )

Here, the authors solve the crystal structure of the kinase bound to a lipid substrate and an ATP analogue, and show that the active site arose through convergent evolution.
(Nature Communications, )

Constructing and testing a number of model catalysts allowed the researchers to clarify the active site as being the carbon atom attached to pyridinic nitrogens in the material.
(Science Daily - News, )

These data reveal the unusually open P. falciparum β2 active site and provide valuable information about active-site architecture that can be used to further refine inhibitor design.
(Nature, )

Furthermore, we can assign the Fe–CO and Fe–CN− ligands at the active site, and can obtain the hydrogen-bond networks and the preferred proton transfer pathway in the hydrogenase.
(Nature, )

Here, the authors report a mechanism-based inhibitor of galactosidases that functions by forming a carbocation within the active site, and subsequently alkylating a nucleophilic residue.
(Nature Communications, )

Here, the authors show that bisphosphine ligands can alter the geometry of the active site in silver catalysts, driving protonation and ultimately extrusion of carbon dioxide from formic acid.
(Nature Communications, )

Iron and nitrogen doped carbon materials are widely studied electrocatalysts, however measurement of features such as intrinsic turn-over frequency and active site utilization has proved difficult.
(Nature Communications, )

We show that after binding MD2, MraYAA undergoes remarkably large conformational rearrangements near the active site, which lead to the formation of a nucleoside-binding pocket and a peptide-binding site.
(Nature, )

Here, the authors solve an atomic structure of Sleeping Beauty (SB) transposase and model the target DNA into the active site, elucidating details that may enable the rational design of novel transposases.
(Nature Communications, )

Researchers have found a protein with an active site that opens and initiates translation only when the protein binds to a small subset of mRNAs -- those critical to regulating the growth and proliferation of cell.
(Science Daily - News, )

We emphasize the importance of dynamics and hydration for enzymatic catalysis and protein design by transplanting the active site from a haloalkane dehalogenase with high enantioselectivity to nonselective dehalogenase.
(Nature Chemical Biology , )

The multi-institutional team used neutron crystallography to uncover detailed interactions of hydrogen bonds at the enzyme’s active site, revealing a pH-induced proton ‘hopping’ mechanism that guides its activity.
(Science Daily - News, )

We use a chemical probe to dissect individual catalytic steps of enoyl-thioester reductases (Etrs), validating an active site tyrosine as the cryptic proton donor and explaining how it had eluded definitive identification.
(Nature Chemical Biology , )

Here the authors show the radical SAM thiamin pyrimidine synthase ThiC comprises an additional active site metal, probably representing an evolutionary link between the radical SAM and adenosylcobalamin-dependent enzyme superfamilies.
(Nature Communications, )

Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structure into the pre-40S maps allows inferences on ribosomal maturation to be drawn.
(Nature Communications, )

An intricate mechanism of ubiquitin-assisted conformational changes activates the enzyme, and while all chain types interact with the enzymatic S1 site, only Lys11-linked chains can bind productively across the active site and stimulate catalytic turnover.
(Nature, )

Because human tyrosyl transfer-RNA (tRNA) synthetase (TyrRS) translocates to the nucleus under stress conditions, we considered the possibility that the tyrosine-like phenolic ring of resveratrol might fit into the active site pocket to effect a nuclear role.
(Nature, )

In influenza virus, the polymerase (FluPol) is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding and endonuclease domains required for transcription initiation by cap-snatching.
(Nature, )

The structure reveals the locations and the detailed folds of 50 mitoribosomal proteins, shows the highly conserved mitoribosomal peptidyl transferase active site in complex with its substrate transfer RNAs, and defines the path of the nascent chain in mammalian mitoribosomes along their idiosyncratic exit tunnel.
(Nature, )

The TEC consists of two extensively interacting subunits: an RNA-dependent RNA polymerase (RdRP) and an NTPase VP4. We find that the bracelet domain of RdRP undergoes marked conformational change when q-CPV is converted to t-CPV, leading to formation of the RNA template entry channel and access to the polymerase active site.
(Nature, )

To examine the mechanism of Dis3l2 substrate recognition we determined the structure of mouse Dis3l2 in complex with an oligoU RNA to mimic the uridylated tail of pre-let-7. Three RNA-binding domains form an open funnel on one face of the catalytic domain that allows RNA to navigate a path to the active site different from that of its exosome counterpart.
(Nature, )

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