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Examples of Adrenocortical


10 examples:

Pediatric adrenocortical carcinoma is a rare malignancy with poor prognosis.
(Nature Communications, )

Jérôme Bertherat, Aurélien de Reyniès and colleagues perform integrated genomic analyses of adrenocortical carcinomas.
(Nature Genetics, )

Current understanding of the pathogenesis of adrenocortical carcinoma (ACC) is incomplete, and treatment options are limited.
(Nature Reviews Endocrinology, )

Integrated genomic analysis has revealed two distinct molecular subsets of adrenocortical carcinomas (ACCs) with opposite clinical outcomes.
(Nature Reviews Endocrinology, )

Significant new findings about adrenocortical carcinoma, a rare cancer with an often poor prognosis, have been revealed by a new study comprised of 39 international institutions.
(Science Daily - News, )

A gain-of-function point mutation in the gene that encodes one of the catalytic subunits of protein kinase A (PRKACA) in cortisol-producing adrenocortical adenomas has been independently reported by three groups.
(Nature Reviews Endocrinology, )

In an advance that could lead to better identification of malignant pediatric adrenocortical tumors, and ultimately to better treatment, researchers have mapped the “genomic landscape” of these rare childhood tumors.
(Science Daily - News, )

Here the authors analyse the genomes, exomes and transcriptomes of 37 such tumours and identify genetic alterations whose nature, timing and potential interactions are key events with prognostic significance in pediatric adrenocortical tumorigenesis.
(Nature Communications, )

Findings from whole-genome, whole-exome and/or transcriptome sequencing of 37 paediatric adrenocortical tumours have demonstrated the prognostic importance of specific mutations. 100% of tumours had IGF2 overexpression, and the majority (78%) had TP53 mutations.
(Nature Reviews Clinical Oncology, )

Primary adrenal Cushing syndrome is the result of cortisol hypersecretion mainly by adenomas and, rarely, by bilateral micronodular or macronodular adrenocortical hyperplasia. cAMP-dependent protein kinase A (PKA) signalling is the major activator of cortisol secretion in the adrenal cortex.
(Nature Reviews Endocrinology, )

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