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Examples of Akt

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50 examples:

PTEN loss, which frequently occurs in cancer, leads to PI3K–AKT activation.
(Nature Reviews Cancer, )

Variant RAF1 proteins show altered kinase activity that causes AKT hyperactivation.
(Nature Genetics, )

Here we report that Akt activity fluctuates across the cell cycle, mirroring cyclin A expression.
(Nature, )

Akt, also known as protein kinase B, plays key roles in cell proliferation, survival and metabolism.
(Nature, )

The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable.
(Nature Communications, )

In cases of facial overgrowth, which involve PTEN/Akt/TOR dysregulation, sirolimus could be used for limiting cell overgrowth.
(BoneKEy Reports, )

Targeted therapy of ErbB2-dependent tumours often provokes an adaptive response leading to reactivation of the PI3K/AKT pathway.
(Nature Communications, )

Here, Zhao et al . show that FOXO1-induced miR-3188 acts as a tumour suppressor in NPC by regulating the axis mTOR/PI3K/Akt/c-Jun.
(Nature Communications, )

Here, the authors show that miR-508 suppresses multiple phosphatases, resulting in constitutive activation of the PI3K/Akt pathway.
(Nature Communications, )

Here the authors show that the ubiquitin ligase NEDD4 is a part of a CD40 signalling complex required for CD40-induced Akt activation.
(Nature Communications, )

AIM2 suppresses colon tumorigenesis, independently of the inflammasome and IL-1β, by interacting with DNA-PK and inhibiting Akt activation.
(Nature Medicine, )

Here the authors show that UCP3 promotes mitochondrial uncoupling and prevents tumorigenesis through a mitochondrially-driven pathway of AKT inhibition.
(Nature Communications, )

Once a week, Ms. Kaiser, founder of the dance-based studios AKT and a host of ABC’s “My Diet Is Better Than Yours,” sleeps late and eats indulgently.
(The New York Times - Arts, )

InR2, by contrast, functions as a negative regulator of the InR1–PI(3)K–Akt pathway: suppression of InR2 results in development of the long-winged morph.
(Nature, )

Here, Seo et al . use shRNA-based genetic selection to identify novel genes regulating cell migration, functioning within the PI 3-kinase/PTEN/AKT signalling pathway.
(Nature Communications, )

Here, Yang et al. show that the protein G-protein-coupled receptor adaptor β-arrestin1 promotes hepatocellular carcinogenesis through pro-inflammatory Akt signalling.
(Nature Communications, )

Mutations that deregulate Notch1 and Ras/phosphoinositide 3 kinase (PI3K)/Akt signalling are prevalent in T-cell acute lymphoblastic leukaemia (T-ALL), and often coexist.
(Nature, )

The authors reveal a surprising new role for this protein in global patterning of dorsal ectoderm in frogs that is mediated by Akt signalling and independent of glycolysis.
(Nature Communications, )

Mutations and post-translational modifications of the PI3K/AKT pathway inhibitor PTEN are a feature of many cancers, but these have not been associated with cervical cancer.
(Nature Communications, )

Here, the authors identify an alternative to membrane PI3K–AKT signalling, a caveolin-1-dependent PTEN pathway that induces nuclear localization and activation of β-catenin.
(Nature Communications, )

Here we show, using in vitro and in vivo assays, that GCB-DLBCL-associated mutations occurring in S1PR2 frequently disrupt the receptor’s Akt and migration inhibitory functions.
(Nature, )

CRISPR-mediated Pten mutation led to elevated Akt phosphorylation and lipid accumulation in hepatocytes, phenocopying the effects of deletion of the gene using Cre–LoxP technology.
(Nature, )

Akt hyperactivation contributes to many pathophysiological conditions, including human cancers, and is closely associated with poor prognosis and chemo- or radiotherapeutic resistance.
(Nature, )

InR1, acting via the phosphatidylinositol-3-OH kinase (PI(3)K)–protein kinase B (Akt) signalling cascade, leads to the long-winged morph if active and the short-winged morph if inactive.
(Nature, )

Scientists have discovered how giving a class of drugs called AKT inhibitors in combination with radiotherapy might boost its effectiveness across a wide range of cancers, according to a new study.
(Science Daily - News, )

Notably, cyclin A2-deletion-induced cellular apoptosis in mouse embryonic stem cells is partly rescued by S477D/T479E-Akt1, supporting a physiological role for cyclin A2 in governing Akt activation.
(Nature, )

Lien et al. show that oncogenic PI(3)K/Akt signalling stimulates glutathione (GSH) synthesis by activation of the transcription factor Nrf2 and regulation of GSH biosynthesis genes in breast cancer.
(Nature Cell Biology, )

The PIK3CA–AKT–mTOR pathway is one of the most commonly activated pathways in human cancers, which has led to the development of small-molecule inhibitors that target various nodes in the pathway.
(Nature, )

Inhibitors of many components of the phosphoinositide 3-kinase (PI3K)–AKT–mammalian target of rapamycin (mTOR) signalling pathway are in various stages of development against different tumour types.
(Nature Reviews Drug Discovery, )

Haetscher et al . show in mice that miR-193b controls the life-long self-renewal ability of HSCs via AKT and STAT5 pathways, with loss of miR-193b accelerating HSC expansion and reducing differentiation.
(Nature Communications, )

Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling.
(Nature Communications, )

Here the authors show that Raptor also exists in a free form, unbound to mTORC, and that this free Raptor negatively regulates hepatic Akt activity and lipid metabolism in mice via a mechanism involving the Akt phosphatase PHLPP2.
(Nature Communications, )

Here, the authors demonstrated that GABRA3 activates AKT to promote breast cancer cell invasion and that the A-to-I edited form of GABRA3, specifically expressed in noninvasive breast cancers, can suppress the function of wild type GABRA3.
(Nature Communications, )

Work in Caenorhabditis elegans identifies a substrate for CED-3 caspase during apoptosis, CNT-1. The cleavage product of CNT-1 localizes to the plasma membrane and blocks the activation of AKT by PIP3, suppressing AKT's prosurvival effects.
(Nature Structural & Molecular Biology, )

The intercommunication was immunosuppressive, involving Ca2+-dependent activation of Akt, because AM-specific knockout of Cx43 enhanced alveolar neutrophil recruitment and secretion of proinflammatory cytokines in the bronchoalveolar lavage.
(Nature, )

The phosphoinositide 3-kinase–AKT–mechanistic target of rapamycin (PI3K–AKT–mTOR) pathway is one of the most commonly activated pathways in human cancer, and a number of agents have been developed against various nodes of the pathway.
(Nature Reviews Drug Discovery, )

Dual inhibition of RAF and the PI(3)K/AKT/mTOR intracellular signalling pathways blunted the outgrowth of the drug-resistant cell population in BRAF mutant human melanoma, suggesting this combination therapy as a strategy against tumour relapse.
(Nature, )

Here the authors discover one such pathway and show that SIKE, an inhibitor of interferon signalling, prevents pathological but not physiological cardiac hypertrophy by interacting with TBK1 and modulating the TBK1/AKT signalling in rodents and monkeys.
(Nature Communications, )

PTEN dephosphorylates phosphatidylinositol (3,4,5)-triphosphate, thereby opposing the activity of class I phosphatidylinositol 3-kinases that mediate growth- and survival-factor signalling through phosphatidylinositol 3-kinase effectors such as AKT and mTOR.
(Nature, )

Here, the authors show that IL-1β signalling via IL-1R1/MyD88 inhibits the Akt/GSK-3β/β-catenin pathway in mesenchymal stem cells, which suppresses their mobilization, proliferation, and differentiation into osteoblasts, processes necessary for bone regeneration.
(Nature Communications, )

Phosphorylation of Akt at S473 (ref. 5) and T308 (ref. 6) activates Akt. However, it remains unclear whether further mechanisms account for full Akt activation, and whether Akt hyperactivation is linked to misregulated cell cycle progression, another cancer hallmark.
(Nature, )

The EphA2 receptor tyrosine kinase is overexpressed in many cancers and is reported to be phosphorylated by Akt. Here, Zhou et al. show that RSK, rather than Akt, phosphorylates EphA2 on Ser-897, and this regulates cell migration and invasion of metastatic cancer cells.
(Nature Communications, )

Together, the results of our study show Akt S477/T479 phosphorylation to be an essential layer of the Akt activation mechanism to regulate its physiological functions, thereby providing a new mechanistic link between aberrant cell cycle progression and Akt hyperactivation in cancer.
(Nature, )

Mechanistically, phosphorylation of S477 and T479 at the Akt extreme carboxy terminus by cyclin-dependent kinase 2 (Cdk2)/cyclin A or mTORC2, under distinct physiological conditions, promotes Akt activation through facilitating, or functionally compensating for, S473 phosphorylation.
(Nature, )

Hyperinflammation in cystic fibrosis has been linked to decreased levels of caveolin-1, resulting in higher LPS responsiveness of TLR4. Here the authors show that in a mouse model of cystic fibrosis decreased Akt results in accumulation of miR-199a-5p directly targeting caveolin-1 in macrophages.
(Nature Communications, )

We find that aTreg cells turned over at a slower rate than rTreg cells, but were not locally maintained in tissues. aTreg cell differentiation was associated with repression of Foxo1-dependent gene transcription, concomitant with reduced Foxo1 expression, cytoplasmic localization and enhanced phosphorylation at the Akt sites.
(Nature, )

The tumour-promoting secretome of melanoma cells treated with the kinase inhibitor vemurafenib is driven by downregulation of the transcription factor FRA1. In situ transcriptome analysis of drug-resistant melanoma cells responding to the regressing tumour microenvironment revealed hyperactivation of several signalling pathways, most prominently the AKT pathway.
(Nature, )

In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS–RAF–MEK–ERK mitogen-activated protein kinase (MAPK) signal transduction pathway, on activation of the alternative, PI(3)K–AKT–mTOR, pathway (which is ERK independent) or on modulation of the caspase-dependent apoptotic cascade.
(Nature, )

We find the KIT/RAS signalling pathway frequently mutated in more than 50% of IGCTs, including novel recurrent somatic mutations in KIT, its downstream mediators KRAS and NRAS, and its negative regulator CBL. Novel somatic alterations in the AKT/mTOR pathway included copy number gains of the AKT1 locus at 14q32.33 in 19% of patients, with corresponding upregulation of AKT1 expression.
(Nature, )

In addition, sclerostin inhibited mineralization promoted by GSK3 inhibition, which mimics canonical Wnt signaling without activation of LRP5/6, suggesting that sclerostin can prevent osteoblast differentiation without antagonizing LRP5/6. Finally, we found that sclerostin could activate platelet-derived growth factor receptor (PDGFR) and its downstream signaling pathways PLCγ, PKC, Akt and ERK1/2. PDGFR inhibition could reverse sclerostin-mediated inhibitory activity on BMP2-induced osteoblast differentiation.
(BoneKEy Reports, )

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