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A new study attributes the pathogenicity of anti-Ro60 autoantibodies and type I interferon in systemic lupus erythematosus and Sjögren syndrome to Alu retroelements, but is this RNA the complete story?
(Nature Reviews Rheumatology, )

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14 examples:

'Alu' sequences are small repetitive elements representing about 10 percent of our genome.
(Science Daily - News, )

ADAR1 is an adenosine deaminase that converts adenosine to inosine (A-to-I) mostly on Alu repeats in human RNA.
(Nature Communications, )

This A-to-I editing occurs not only in protein-coding regions of mRNAs, but also frequently in non-coding regions that contain inverted Alu repeats.
(Nature Reviews Molecular Cell Biology, )

Here we show that DHX9, an abundant nuclear RNA helicase, binds specifically to inverted-repeat Alu elements that are transcribed as parts of genes.
(Nature, )

Here, Klawitter et al. identify endogenous L1, Alu and SVA mobilization during reprogramming, highlighting the risk of insertional mutagens in hiPSCs.
(Nature Communications, )

Alu elements belong to the short interspersed nuclear element (SINE) family of repetitive elements, and with over 1 million insertions they make up more than 10% of the human genome.
(Nature, )

Here by analysing transcriptome-wide ADAR1–RNA interactions, the authors show that ADAR1 also binds non- Alu sequences to regulate alternative 3′ UTR usage and miRNA biogenesis in the nucleus.
(Nature Communications, )

A conserved long noncoding RNA expressed at the 5S rDNA ribosomal locus has acquired a novel function in alternative-splicing regulation in primates, owing to the insertion of a mobile Alu element.
(Nature Structural & Molecular Biology, )

In addition to her quotidian duties of organizing events, writing press releases and the like, she has developed her own internal training program to elevate the skills of ALU’s female executives.
(Forbes - Technology, )

Two new studies show that RNA-binding proteins can mediate distinct and beneficial effects to cells by binding to the extensive double-stranded RNA (dsRNA) structures of inverted-repeat Alu elements (IRAlus).
(Nature Structural & Molecular Biology, )

A primate-specific insertion of an Alu element in 5S-OT, a lncRNA transcribed from 5S rRNA loci, allows 5S-OT to regulate alternative splicing via RNA-RNA pairing and recruitment of the splicing factor U2AF65.
(Nature Structural & Molecular Biology, )

Despite their abundance and the potential evolutionary advantages they confer, Alu elements can be mutagenic to the host as they can act as splice acceptors, inhibit translation of mRNAs and cause genomic instability.
(Nature, )

Alu elements are the main targets of the RNA-editing enzyme ADAR and the formation of Alu exons is suppressed by the nuclear ribonucleoprotein HNRNPC, but the broad effect of massive secondary structures formed by inverted-repeat Alu elements on RNA processing in the nucleus remains unknown.
(Nature, )

Loss of DHX9 leads to an increase in the number of circular-RNA-producing genes and amount of circular RNAs, translational repression of reporters containing inverted-repeat Alu elements, and transcriptional rewiring (the creation of mostly nonsensical novel connections between exons) of susceptible loci.
(Nature, )

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