Examples of Amides
Amides are common functional groups that have been studied for more than a century.
We use this methodology to convert amides to esters, which is a challenging and underdeveloped transformation.
Amides are known to be poor electrophiles, which is typically attributed to the resonance stability of the amide bond.
Although amides can readily be cleaved by enzymes such as proteases, it is difficult to selectively break the carbon–nitrogen bond of an amide using synthetic chemistry.
The team used the solvent-free, catalytic reaction to produce high yields of a wide range of amides, including the antidepressant moclobemide and other drug-like molecules.
(Science Daily - News, )
These observations are made for a class of unsymmetrical amides that exhibits two asymmetric axes—one axis is defined through a benzamide substructure, and the other axis is associated with differentially N,N-disubstituted amides.
Our results provide a way to harness amide functional groups as synthetic building blocks and are expected to lead to the further use of amides in the construction of carbon–heteroatom or carbon–carbon bonds using non-precious-metal catalysis.
See also examples for amide.
Share this page
Go to the wordplay of Amides for some fun with words!