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Examples of Activator

Sentences with the noun Activator

5 examples:

Ndfip1 is an activator of Itch E3 ubiquitin ligase that limits T cell activation.
(Nature Communications, )

Tuberous sclerosis complex (TSC) arises from mutations in an activator of the small GTPase Rheb.
(Nature Communications, )

Sun et al. now identify Kank2 as an activator of talin that reduces force transmission across focal adhesions.
(Nature Cell Biology, )

Here, the authors describe that the proteins physically interact and that this changes the transcriptional activity of ZEB1 from a repressor to an activator.
(Nature Communications, )

Here Zhang et al. reveal that S -nitrosylation of the activator of Cdk5, p35, by nitric oxide results in its degradation and reduced Cdk5 activity, leading to alterations in synaptic strength.
(Nature Communications, )

Other sentences

46 examples:

κB has largely been known as a transcriptional activator.
(Nature Communications, )

Activator E2Fs and Myc cooperate as master regulators of proliferation.
(Nature Cell Biology, )

Nrf2 is a transcriptional activator of oxidative stress response genes.
(Nature Communications, )

These findings demonstrate that phosphorylated ubiquitin is a parkin activator.
(Nature, )

33, released by epithelial cells in response to stress, is a potent activator of inflammation.
(Nature Communications, )

They establish that NOXA is a direct activator of BAX/BAK and not merely a sensitizer as previously suggested.
(Nature Cell Biology, )

Some repressors down-regulate gene expression when they bind to a site up to 100 base pairs away from the nearest activator.
(Nature Communications, )

Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator.
(Nature Communications, )

The defect occurs at the transcriptional level and seems to reflect influences of mHtt on specificity protein 1, a transcriptional activator for CSE.
(Nature, )

A previously unknown function for TH17 cell–derived IL-26 as a direct antimicrobial agent and activator of DNA-sensing innate immunity is now reported.
(Nature Immunology, )

Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients.
(Nature Communications, )

Discovery of the receptor activator of nuclear factor -κB ligand (RANKL) uncovered the molecular mechanism by which 1α,25(OH)2D3 stimulates bone resorption.
(BoneKEy Reports, )

Receptor activator of NF-κB ligand (RANKL) is a key factor in osteoclast differentiation that induces changes in the chromatin state of osteoclast precursors.
(Nature Reviews Drug Discovery, )

Yin and colleagues demonstrate that the phosphatase DUSP2 targets the transcription activator STAT3 to regulate the differentiation and function of TH17 cells.
(Nature Immunology, )

Here, the authors present a synthesis of phosphorothioated RNAs, where the activator controls strand stereochemistry, and also the activity of assembled siRNAs.
(Nature Communications, )

Schulz and Rehling show that continuous recruitment and dissociation of the Hsp70 ATPase activator Pam18 is required to regulate the activity of the import motor.
(Nature Communications, )

Acting through its cognate receptor, receptor activator of nuclear factor-B (RANK), RANK ligand (RANKL) is an essential mediator of osteoclast function and survival.
(BoneKEy Reports, )

The Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) proteins, particularly STAT3, are among the most promising new targets for cancer therapy.
(Nature Reviews Cancer, )

New research shows that coating implants with a certain 'activator' can prevent Staphylococcus aureus, the leading cause of hospital-acquired infections, from forming biofilms.
(Science Daily - News, )

This was caused by reduced autophagy in Gcn2−/− intestinal APCs and epithelial cells, leading to increased reactive oxygen species (ROS), a potent activator of inflammasomes.
(Nature, )

Zhou et al. identify microRNA-302b as a feedback suppressor of inflammatory signalling that alleviates lung injury following Pseudomonas infection by targeting the NF-κB activator IRAK4.
(Nature Communications, )

The repurposing of a bacterial defence system known as CRISPR into a potent activator of gene expression in human cells enables powerful studies of gene function, as exemplified in cancer cells.
(Nature, )

The resulting protein is a potent transcriptional activator of PAX3 response elements and is associated with aberrant expression of genes involved in neuroectodermal and myogenic differentiation.
(Nature Genetics, )

Czarnecki et al . identify the cilliary protein ANKS6 as a target and crucial activator of NEK8 and describe the importance of this protein interaction in embryonic development and organogenesis.
(Nature Communications, )

Here the authors use patient samples plus mouse studies to show a central role for tenascin C as a TLR4 activator responsible for persistence of fibrosis in the context of SSc and SSc-like disease.
(Nature Communications, )

Under physiological conditions, the osteoclastogenesis pathway depends on macrophage colony-stimulating factor 1 (CSF-1, also known as M-CSF) and receptor activator of nuclear factor κB ligand (RANKL).
(Nature Reviews Rheumatology, )

Here Gavish et al. model lateral inhibition in the developing eye to understand how developmental noise refines such patterning, identifying a novel activator required for buffering spatial variability.
(Nature Communications, )

The COP9 signalosome complex (CSN) regulates CRLs by removing their ubiquitin-like activator NEDD8. The CUL4A–RBX1–DDB1–DDB2 complex (CRL4ADDB2) monitors the genome for ultraviolet-light-induced DNA damage.
(Nature, )

Here the authors introduce a naturally occurring mutation in the γ-globin promoter and show that it causes binding of an activator TAL1, chromosome looping and revival of fetal haemoglobin expression in erythroid cells.
(Nature Communications, )

Janus kinase–signal transducer and activator of transcription (JAK-STAT) signal transduction is a crucial regulator of muscle regeneration, and targeting this pathway in mice relieves aspects of debilitating muscle wasting.
(Nature Medicine, )

Here we show that the fed-state sensing nuclear receptor farnesoid X receptor (FXR) and the fasting transcriptional activator cAMP response element-binding protein (CREB) coordinately regulate the hepatic autophagy gene network.
(Nature, )

A new study provides experimental evidence that blocking the generation of myofibroblasts by inhibiting GLI2—a transcriptional activator of hedgehog (Hh) signalling—might reduce fibrosis and slow the progression of kidney disease.
(Nature Reviews Nephrology, )

The Copernican revolution in osteoclast biology began with the identification of macrophage-colony stimulating factor (M-CSF) and receptor activator NFκB-ligand (RANKL ) as the key regulators of osteoclast formation, fusion and function.
(BoneKEy Reports, )

A mutant form of a bacterium that lives in soil and thrives in low-oxygen environments appears to be a precise and aggressive killer of malignant tumors as well as an energetic activator of the body's immune system, according to new research.
(Melissa Healy in Los Angeles Times - Science, )

The pro-haematopoietic effects of EETs were conserved in the developing zebrafish embryo, where 11,12-EET promoted HSPC specification by activating a unique activator protein 1 (AP-1) and runx1 transcription program autonomous to the haemogenic endothelium.
(Nature, )

Here we propose that the inhibitory cascade, an activator–inhibitor mechanism that affects relative tooth size in mammals, produces the default pattern of tooth sizes for all lower primary postcanine teeth (deciduous premolars and permanent molars) in hominins.
(Nature, )

Receptor activator of nuclear factor κB ligand (RANKL, also known as TNFSF11) has long been considered essential for osteoclast differentiation, until the recent identification of lysyl oxidase (LOX) as a RANKL-independent stimulator of osteoclastogenesis by Cox and colleagues.
(Nature Reviews Rheumatology, )

SMAD4-mutant pancreatic ductal adenocarcinomas (PDACs) with impaired transforming growth factor-β (TGFβ) signalling initiate a signal transducer and activator of transcription 3 (STAT3)-dependent signalling pathway that leads to increased stromal stiffening and aggressive disease.
(Nature Reviews Cancer, )

Here, Zhang and Reed use CRISPR/Cas9 genome editing to show that while spalt is a positive regulator of eyespots as predicted, Dll knockouts have positive effects on both eyespot size and number, thus suggesting that Dll is an eyespot repressor, not an activator as previously thought.
(Nature Communications, )

Primary adrenal Cushing syndrome is the result of cortisol hypersecretion mainly by adenomas and, rarely, by bilateral micronodular or macronodular adrenocortical hyperplasia. cAMP-dependent protein kinase A (PKA) signalling is the major activator of cortisol secretion in the adrenal cortex.
(Nature Reviews Endocrinology, )

REGγ, a proteasome activator, is associated with multiple oncogenic pathways in human cancers and can promote the degradation of multiple proteins including p53. Here the authors highlight a potential role for REGγ in skin cancer and propose a molecular mechanism linking p38 MAPK and Wnt signalling.
(Nature Communications, )

Endocrine-disrupting chemicals act on nuclear hormone receptors, such as PXR. Here, Delfosse et al . show how two such chemicals interact with each other in the PXR ligand-binding pocket, forming a so-called supramolecular ligand that is a more potent PXR activator than each of the two chemicals alone.
(Nature Communications, )

New data show that Clock–Bmal1, the central transcriptional activator that drives expression of circadian target genes, also recruits the Ddb1–Cullin-4 ubiquitin ligase to clock promoters to enhance the subsequent binding of the feedback repressors that generate the circadian periodicity of gene expression.
(Nature Structural & Molecular Biology, )

In osteocytes, OSM can suppress the production of the bone formation inhibitor sclerostin, an action that is mediated by LIFR:gp130. OSM also stimulates the production of receptor activator of nuclear factor κB ligand by osteoblasts and thereby drives the formation of osteoclasts particularly in pathological conditions.
(BoneKEy Reports, )

In fission yeast, cell growth is co-ordinated with division by the cell tip-localized DYRK kinase Pom1, which inhibits the medially placed mitotic activator Cdr2. Here, Kelkar and Martin show that, upon glucose starvation, microtubules are destabilized in a PKA-dependent manner, leading to the deposition of Pom1 at cell sides where it delays mitosis.
(Nature Communications, )

Here we show that substitution of the conserved glycine 388 residue to a charged arginine residue alters the transmembrane spanning segment and exposes a membrane-proximal cytoplasmic signal transducer and activator of transcription 3 (STAT3) binding site Y390-(P)XXQ393. We demonstrate that such membrane-proximal STAT3 binding motifs in the germline of type I membrane receptors enhance STAT3 tyrosine phosphorylation by recruiting STAT3 proteins to the inner cell membrane.
(Nature, )

Other examples

See also examples for activators, plasminogen activator.

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