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Examples of Adenosine

Sentences

33 examples:

Caffeine is a purinergic antagonist that competitively inhibits adenosine at the sites of P1 receptors.

However, the role of adenosine in human BAT is unknown.
(Nature, )

The adenosine A2A receptor is the most abundant adenosine receptor in human and murine BAT.
(Nature, )

The conversion of adenosine to inosine is catalysed on double-stranded RNA (dsRNA) by ADAR deaminases.
(Nature Reviews Molecular Cell Biology, )

Adenosine is released in BAT during stimulation of sympathetic nerves as well as from brown adipocytes.
(Nature, )

The authors show that astrocytes produce high levels of the adenosine receptor A2A in Alzheimer brains.
(Nature Neuroscience, )

Here we show that adenosine activates human and murine brown adipocytes at low nanomolar concentrations.
(Nature, )

The ectonucleotidase CD39 ultimately generates extracellular adenosine, modulating paracrine purinergic signaling.
(Nature Communications, )

Targeting adenosine receptors might be a promising approach to promote bone regeneration, according to new research.
(Nature Reviews Endocrinology, )

Here we show that BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells.
(Nature, )

The assembly of molecules can twist reversibly and quickly in response to changes in the type of adenosine phosphate present.
(Nature Chemistry, )

Here we present the structure of the adenosine A2A receptor (A2AR) bound to an engineered G protein, mini-Gs, at 3.4 Å resolution.
(Nature, )

Adenosine stimulates energy expenditure in brown adipose tissue (BAT) of humans and mice, report Alexander Pfeifer and colleagues in Nature.
(Nature Reviews Endocrinology, )

Adenylate kinase catalyses the interconversion of adenosine phosphates, and plays a crucial role in maintaining cellular energy homeostasis.
(Nature Communications, )

Antitumour T cells are suppressed by hypoxic tumour areas enriched in extracellular adenosine through activation of A2A adenosine receptors (A2ARs).
(Nature Reviews Cancer, )

CD73 is the crucial enzyme for generating adenosine, a signaling molecule important for regulation of normal tissue function and stability or homeostasis.
(Science Daily - News, )

Here we report the discovery of a novel small molecule GS-5734, a monophosphoramidate prodrug of an adenosine analogue, with antiviral activity against EBOV.
(Nature, )

The scientists discovered a new way to stimulate brown fat and thus burn energy from food: The body's own adenosine activates brown fat and "browns" white fat.
(Science Daily - News, )

Here, the authors present an ATP assay, using a supramolecular helix to switch between left- and right-handed conformations on binding different adenosine phosphates.
(Nature Communications, )

Nature Reviews Neuroscience15, 825834 (2014)In table 1, methylxanthines should have been listed as adenosine A1 and A2 receptor antagonists (rather than agonists).
(Nature Reviews Neuroscience, )

Methylation of adenosine within mRNA coding regions delays tRNA accommodation during translation and thus changes translation dynamics, which might influence protein folding.
(Nature Structural & Molecular Biology, )

Scientists at the University of Bonn have discovered a way to ‘melt’ excess white fat by adding the adenosine receptor A2A to the cells, which make them burn energy from food.
(Daily Mail - Science, )

According to a new study, silk implants placed in the brain of laboratory animals and designed to release a specific chemical, adenosine, may help stop the progression of epilepsy.
(Science Daily - News, )

Here we use 19F nuclear magnetic resonance to quantify the conformational landscape occupied by the adenosine A2A receptor (A2AR), a prototypical class A G-protein-coupled receptor.
(Nature, )

Caffeine blocks the fatigue- causing chemical adenosine making people less tired and more motivated to continue exercising, said Professor Samuele Marcora, from the University of Kent.
(Daily Mail - Health, )

Here, the authors find adenosine A2A receptors are up-regulated in APP/PS1 model mice and that deleting or blocking receptor activity helps alleviate plasticity and memory impairments.
(Nature Communications, )

Taken together, our results demonstrate that adenosine–A2A signalling plays an unexpected physiological role in sympathetic BAT activation and protects mice from diet-induced obesity.
(Nature, )

Purinergic co-transmission might be involved in sympathetic control of BAT and previous studies reported inhibitory effects of the purinergic transmitter adenosine in BAT from hamster or rat.
(Nature, )

Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine receptors.
(Nature Reviews Endocrinology, )

Scientists have now published a study showing that the substance previously identified as the major allergen only induces such a vigorous allergic response in combination with the adenosine also present in the pollen.
(Science Daily - News, )

The TGS (ThrRS, GTPase and SpoT) domain of RelA binds the CCA tail to orient the free 3′ hydroxyl group of the terminal adenosine towards a β-strand, such that an aminoacylated tRNA at this position would be sterically precluded.
(Nature, )

The study shows that the abnormal expression of a particular receptor -- adenosine A2A, a target for caffeine -- in the brain of rats induces an aging-like profile: namely, memory impairments linked to the loss of stress controlling mechanisms.
(Science Daily - News, )

Using latest-generation molecular simulations researchers have demonstrated that a decrease in polyunsaturated lipids in neuronal membranes, as seen in Parkinson's and Alzheimer's sufferers, directly affects the binding rate of dopamine and adenosine receptors.
(Science Daily - News, )

Other examples

See also examples for adenosines, adenosine deaminase, adenosine diphosphate, adenosine triphosphate, adenosine monophosphate.

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