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Examples of Adipose tissue

Sentences with the noun Adipose tissue

12 examples:

A team of researchers has now investigated the role of LPR5 in adipose tissue.
(Nature Reviews Endocrinology, )

Immunosuppressive regulatory T-cells play an important role in the functioning of adipose tissue.
(Science Daily - News, )

Insulin sensitivity in the treated mice was improved and inflammation of adipose tissue was unaffected.
(Nature Reviews Endocrinology, )

Expansion of visceral adipose tissue is usually associated with insulin resistance and metabolic disease.
(Nature Communications, )

The higher the intensity of physical activity, the stronger the association with the amount of adipose tissue.
(Science Daily - News, )

Yet, understanding this mechanism is of crucial importance to prevent the diseases related to fat accumulation in adipose tissue.
(Science Daily - News, )

Exchanging sedentary behavior -- mainly sitting -- for even low-intensity physical activity reduces the amount of adipose tissue.
(Science Daily - News, )

The study shows that exenatide, a treatment that targets the pancreas to improve glucose absorption, enhances glucose uptake and reduces insulin resistance in the liver and in adipose tissue.
(Science Daily - News, )

NNMT inhibition increases adipose SAM and NAD+ levels and upregulates ODC and SSAT activity as well as expression, owing to the effects of NNMT on histone H3 lysine 4 methylation in adipose tissue.
(Nature, )

Here, the authors show that plasma amino acid and triglyceride levels are linked by a neuronal mechanism that couples amino acid sensing in the liver with the expression of lipoprotein lipase in adipose tissue.
(Nature Communications, )

Their findings suggest that limited storage capacity of peripheral adipose tissue is an important etiological component in insulin-resistant cardiometabolic disease and highlight genes and mechanisms underpinning this link.
(Nature Genetics, )

In states of obesity, the development and fibrotic progression of nonalcoholic fatty liver disease (NAFLD) from nonalcoholic steatohepatitis (NASH) to cirrhosis has been proposed to stem from chronic, low-level type 1 inflammation in adipose tissue.
(Nature Reviews Endocrinology, )

Other sentences

72 examples:

Insulin resistance in adipose tissue is a hallmark of obesity.
(Nature Communications, )

Adipose tissue secretes highly bioactive factors, the adipokines.
(Nature Reviews Rheumatology, )

Fsp27 mediates ‘fusion’ of lipid droplets in mouse adipose tissue.
(Nature Communications, )

Visceral adipose tissue (VAT) inflammation drives obesity-induced insulin resistance.
(Nature Immunology, )

In 2014, numerous noteworthy papers focusing on adipose tissue physiology were published.
(Nature Reviews Endocrinology, )

Group 2 innate lymphoid cells promote beiging of adipose tissue and protect against obesity.
(Nature Reviews Immunology, )

The function and distribution of adipose tissue in the body change during the course of life.
(Science Daily - News, )

Our understanding of adipose tissue biology has progressed rapidly since the turn of the century.
(Nature, )

Epicardial adipose tissue is a unique and multifaceted fat depot with local and systemic effects.
(Nature Reviews Endocrinology, )

The mechanisms underlying the different distribution of adipose tissue in men and women are unclear.
(Nature Reviews Endocrinology, )

This seasonality also affects our immune cells and the composition of our blood and adipose tissue (fat).
(Science Daily - News, )

Bone marrow contains adipocytes, which have been thought to form one type of marrow adipose tissue (MAT).
(Nature Communications, )

In a recent study, beige adipocytes were derived from the capillaries of human subcutaneous adipose tissue.
(Nature Medicine, )

Activation of the IRE1α-mediated stress response pathway in adipose tissue macrophages suppresses M2 polarization.
(Nature Reviews Immunology, )

The distribution of adipose tissue in the body has wide-ranging and reproducible associations with health and disease.
(Nature Reviews Endocrinology, )

The adipokine endotrophin promotes tumour inflammation and angiogenesis, but its effects on adipose tissue are unclear.
(Nature Communications, )

Scientists have carried out the first molecular characterization of the African elephant’s adipose tissue -- body fat.
(Science Daily - News, )

Neutralization of PTHrP in tumour-bearing mice blocked adipose tissue browning and the loss of muscle mass and strength.
(Nature, )

A gene driving the development of pernicious adipose tissue in humans has been identified by researchers for the first time.
(Science Daily - News, )

By contrast, selective depletion of fTreg cells via anti-ST2 antibody treatment increases adipose tissue insulin sensitivity.
(Nature, )

Adipose tissue is a major site of energy storage and has a role in the regulation of metabolism through the release of adipokines.
(Nature, )

The authors also describe the involvement of steroid hormones and others factors produced by adipose tissue in breast cancer development.
(Science Daily - News, )

Adipose tissue, or fat, may influence the development of cancer in diverse ways, depending on the type of fat and the location in the body.
(Science Daily - News, )

‘Crown-like’ structures composed of apoptotic adipocytes surrounded by adipose tissue macrophages (ATMs) are a characteristic of obesity.
(Nature Immunology, )

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines.
(Nature Reviews Rheumatology, )

However, ILC2s have not been identified in human adipose tissue, and the mechanisms by which ILC2s regulate metabolic homeostasis remain unknown.
(Nature, )

The fatty acid linoleic acid (Omega 6) in subcutaneous adipose tissue was linked to lower mortality among older men followed over a 15-year period.
(Science Daily - News, )

New research has found that the exosomal microRNAs (miRNAs) produced by adipose tissue affect gene expression in distant organs, such as the liver.
(Nature Reviews Endocrinology, )

Kallies and colleagues show interleukin 33 and the transcription factors BATF and IRF4 are necessary to maintain visceral adipose tissue Treg cells.
(Nature Immunology, )

Deleting Fasn in macrophages prevents diet-induced insulin resistance, recruitment of macrophages to adipose tissue and chronic inflammation in mice.
(Nature, )

Polić and colleagues show that VAT NK cells sense obesity-induced adipose tissue stress and drive inflammation through the production of interferon-γ.
(Nature Immunology, )

In the dermis, adipose tissue expands in sync with the growth of hair follicles, but the mechanism that couples the growth of the two tissues is unclear.
(Nature Reviews Endocrinology, )

Insulin resistance is a hallmark of type 2 diabetes and is associated with inflammation of insulin target tissues such as adipose tissue, muscle and liver.
(Nature Reviews Drug Discovery, )

Obesity is marked by a state of low-grade inflammation, including the accumulation of macrophages in the adipose tissue, which results in insulin resistance.
(Nature Medicine, )

Limiting expansion of visceral adipose tissue (VAT) while expanding subcutaneous adipose tissue (SAT) improves glucose homeostasis, according to a new study.
(Nature Reviews Endocrinology, )

Adipose tissue is a novel niche for T. brucei in mammalian hosts, and the parasite may adapt its metabolism in this niche to use fatty acids as a carbon source.
(Nature Reviews Microbiology, )

Here we show that adipose tissue macrophages regulate the age-related reduction in adipocyte lipolysis in mice by lowering the bioavailability of noradrenaline.
(Nature, )

Scientists report that turning off a protein found in liver and adipose tissue significantly improves blood sugar levels and reduces body fat in an animal model.
(Science Daily - News, )

A major function of miRNAs in adipose tissue is to stimulate or inhibit the differentiation of adipocytes, and to regulate specific metabolic and endocrine functions.
(Nature Reviews Endocrinology, )

The lack of this hormone triggers a cascade of neuroendocrine events that affect adipose tissue and the liver, resulting in hyperglycemia and ketoacidosis (pages 759763).
(Nature Medicine, )

Maintaining a high quality diet during mid-to-late adulthood may prevent adverse metabolic consequences related to visceral adipose tissue (VAT) and non-alcoholic fatty liver (NAFL).
(Science Daily - News, )

Increased infiltration of adipose tissue macrophages (ATMs) and their subsequent inflammatory effects are implicated in the development of insulin resistance among individuals with obesity.
(Nature Reviews Endocrinology, )

Here we show, using comparative adipo-immune profiling in mice, that fat-resident regulatory T cells, termed fTreg cells, accumulate in adipose tissue as a function of age, but not obesity.
(Nature, )

As little as 10 minutes of high-intensity physical activity per day reduces the amount of adipose tissue and enhances cardiorespiratory fitness in 6-8-year-old children, according to a new study.
(Science Daily - News, )

Here, Sun et al. show that endotrophin promotes adipose tissue inflammation and fibrosis, and that injections of an anti-endotrophin antibody improve metabolic parameters of mice on a high-fat diet.
(Nature Communications, )

Here, the authors show that the membrane protein TNMD is upregulated in visceral fat of insulin resistant obese individuals and promotes healthy adipose tissue expansion through increasing adipogenesis.
(Nature Communications, )

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM).
(Nature Reviews Drug Discovery, )

Obesity is associated with prostate cancer that is locally disseminated into the periprostatic adipose tissue (PPAT) that surrounds the prostate gland and Laurent et al. have found a possible explanation.
(Nature Reviews Cancer, )

Accumulation of adipose tissue in the upper body (abdominal obesity) is associated with the development of cardiovascular disease, insulin resistance, type 2 diabetes mellitus and even all-cause mortality.
(Nature Reviews Endocrinology, )

MicroRNAs (miRNAs) produced in adipose tissue cells and released into the circulation encapsulated in small extracellular vesicles (exosomes) can affect gene expression in distant organs, new research shows.
(Nature Reviews Genetics, )

As the prevalence of obesity continues to increase, there is a growing interest in understanding the interactions between nutritional regulators from the gut and adipose tissue and their influence on bone mass.
(BoneKEy Reports, )

Homozygous S999A mice exhibited low body weight, reduced adipose tissue mass, and increased lifespan, similar to S6K1-deficient mice and mice with adipocyte-specific deficiency of raptor, an mTORC1 constituent.
(Nature, )

A novel image-analysis method using standard CT imaging demonstrates that changes in the CT signal of coronary perivascular adipose tissue are associated with the degree of inflammation in adjacent coronary plaques.
(Nature Reviews Cardiology, )

Here, the authors show that periprostatic adipose tissue promotes the migration and local invasion of prostate cancer cells by secreting the chemokine, CCL7, and that this process is enhanced in the context of obesity.
(Nature Communications, )

A new study by Minna Woo and colleagues shows that a neuronal relay from the brain to the adipose tissue regulates whole-body insulin sensitivity by affecting macrophage function, and thus inflammation, in the periphery.
(Nature Medicine, )

Here the authors show that Mincle expressed in macrophages is a mediator of obesity-induced fibrosis and inflammation of adipose tissue, and that Mincle knockout mice are protected from diet-induced metabolic dysfunction.
(Nature Communications, )

These findings offer an explanation to the positive outcome on the skeleton triggered by skeletal muscle during physical activity and prove that the bone tissue is more sensitive than the adipose tissue to the Irisin action.
(BoneKEy Reports, )

Here the authors report the peptide, P5, a variant of the GLP-1 receptor agonist exendin-4, with 'biased' signalling activity, and show that P5 improves glucose homeostasis in diabetic mice by increasing adipose tissue hyperplasia.
(Nature Communications, )

Here, the authors investigate the physiological consequences of loss of Fsp27 in three different mouse models of ‘energetic overload’, and observe hepatic steatosis and insulin resistance but reduced adipose tissue inflammation.
(Nature Communications, )

Susceptibility to impaired metabolic health in relation to obesity is not necessarily mediated by overall fatness, but is largely dependent on the distribution of body fat and the ability to sufficiently expand adipose tissue depots.
(Nature Reviews Endocrinology, )

Here, the authors generate inducible adipocyte-specific PTEN knockout mice to demonstrate that enhanced insulin sensitivity in adipose tissue is directly linked to improved systemic metabolic homeostasis, despite an increase in fat mass.
(Nature Communications, )

A study published today is the first to use direct radiographic imaging of adipose tissue rather than estimates like body mass index or waist circumference, and focuses on the relationship between obesity and cancer risk in aging populations.
(Science Daily - News, )

Because of the expanding research using micro-CT to study other skeletal sites, as well as soft tissues, we also provide a review of current techniques to examine the skull and mandible, adipose tissue, vasculature, tumour severity and cartilage.
(BoneKEy Reports, )

These findings establish that distinct immune cell populations within adipose tissue underlie ageing- and obesity-associated IR, and implicate fTreg cells as adipo-immune drivers and potential therapeutic targets in the treatment of age-associated IR.
(Nature, )

Researchers have recently elucidated one of these mechanisms in prostate cancer, one of the most common cancers in men: in obese patients, the adipose tissue surrounding the prostate gland facilitates the propagation of tumor cells outside the prostate.
(Science Daily - News, )

Activation of thermogenesis in beige adipose tissue has been proposed as a potential strategy to treat obesity and type 2 diabetes mellitus; however, implementation of this approach has been hampered by a limited supply of beige adipocytes for therapeutic screening.
(Nature Reviews Endocrinology, )

Although the health-promoting effects of exercise are largely ascribed to improvements in skeletal muscle insulin sensitivity, new data published in Diabetes suggest 'exercise-trained' subcutaneous adipose tissue might also have an important role in enhancing glucose homeostasis.
(Nature Reviews Endocrinology, )

Glucagon action is transduced by the class B G-protein-coupled glucagon receptor (GCGR), which is located on liver, kidney, intestinal smooth muscle, brain, adipose tissue, heart and pancreas cells, and this receptor has been considered an important drug target in the treatment of diabetes.
(Nature, )

Congenital generalized lipodystrophy (CGL) is a heterogeneous autosomal recessive disorder characterized by a near complete lack of adipose tissue from birth and, later in life, the development of metabolic complications, such as diabetes mellitus, hypertriglyceridaemia and hepatic steatosis.
(Nature Reviews Endocrinology, )

New research published in Cell Metabolism reveals a role for 'healthy inflammation' in adipose tissue, which is required for adipocyte remodelling and expansion.It is widely accepted that chronic systemic low-grade inflammation is associated with the development of obesity and metabolic dysfunction.
(Nature Reviews Endocrinology, )

The findings imply that the gene may constitute a risk factor promoting the development of insulin resistance and type 2 diabetes. "Our findings represent an important step forward in the understanding of how adipose tissue links to the development of metabolic disease," comments one of the principal investigators.
(Science Daily - News, )

Consistent with this, deletion of GDF3 in inflammasome-activated macrophages improved lipolysis by decreasing levels of MAOA and caspase-1. Furthermore, inhibition of MAOA reversed the age-related reduction in noradrenaline concentration in adipose tissue, and restored lipolysis with increased levels of the key lipolytic enzymes adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL).
(Nature, )

Other examples

See also examples for adipose tissues, Brown adipose tissue, White adipose tissue.

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