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Header of aetiology

Examples of Aetiology

Sentences with the noun Aetiology

25 examples:

Hepatic insulin resistance is a hallmark of diabetes, but its aetiology is incompletely understood.
(Nature Communications, )

Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D).
(Nature Communications, )

Mouse models have pointed to a role for dysbiosis of the gut microbiota during early life in the aetiology of asthma.
(Nature Reviews Microbiology, )

Major progress has been made in our understanding of the aetiology of many disorders with the advent of next-generation sequencing.
(Nature Reviews Endocrinology, )

Multiple sclerosis (MS) has been thought to be a complex and indecipherable disease, and poorly understood with regards to aetiology.
(Nature Reviews Neurology, )

Epigenetic regulation is a vital driver of the aetiology of human disease, with research breakthroughs now occurring on a regular basis.
(Nature Reviews Rheumatology, )

With no cell lines available, investigating the aetiology of human fibrolamellar hepatocellular carcinomas (hFL-HCCs) has proved problematic.
(Nature Communications, )

Although the aetiology of diabetic ED is multifactorial, endothelial dysfunction is recognized as a mainstay in the pathophysiology of the disease.
(Nature Reviews Urology, )

The connection between the gut microbiota and the aetiology of obesity and cardiometabolic disorders is increasingly being recognized by clinicians.
(Nature Reviews Endocrinology, )

In this study, the authors identify somatic mutations of the MLLT1 gene that are potentially involved in the aetiology of a subset of Wilms tumours.
(Nature Communications, )

The aetiology of autism-spectrum disorders is partly explained by genetic factors, but a substantial component is attributed to environmental exposures.
(Nature Reviews Endocrinology, )

Epigenetic changes are thought to contribute to the aetiology of common variable immunodeficiency (CVID), a disease characterized by loss of B-cell function.
(Nature Communications, )

Great advances have been made in our understanding of Takotsubo syndrome in the past decade, but the aetiology of the condition remains incompletely understood.
(Nature Reviews Cardiology, )

Microbial components have been implicated in the aetiology of rheumatoid arthritis (RA), but the identity of microbes that associate with this disease is unclear.
(Nature Reviews Rheumatology, )

Although the obesity epidemic is largely fueled by poor nutrition and lack of exercise, certain chemicals have been shown to potentially have a role in its aetiology.
(Nature Reviews Endocrinology, )

The aetiology of Mesoamerican nephropathy is unknown, but is thought to involve repeated episodes of daily dehydration and hypovolaemia associated with rhabdomyolysis.
(Nature Reviews Nephrology, )

Understanding the aetiology of epilepsy is essential both for clinical management of patients and for conducting neurobiological research that will direct future therapies.
(Nature Reviews Neurology, )

Nature505, 550554 (2014); doi:10.1038/nature12825Interest in the role of rare genetic variants in the aetiology of complex diseases such as Alzheimer's disease is increasing.
(Nature, )

By identifying the vulnerability factors underlying individual differences in alcohol misuse, these models shed light on the aetiology of alcohol misuse and suggest targets for prevention.
(Nature, )

The aetiology of type 2 diabetes mellitus (T2DM) involves interactions between genetic, developmental and lifestyle environmental risk factors, which are partly influenced by epigenetic processes.
(Nature Reviews Endocrinology, )

The gut microbiota has long been known to be fundamental to the aetiology of sepsis and acute respiratory distress syndrome (ARDS); however, the mechanistic role of the gut microbiota in lung pathology has remained unknown.
(Nature Reviews Microbiology, )

The identification of a regulatory site on the UBE3A protein that can be phosphorylated to alter its enzymatic activity provides insight into the aetiology of two human neurodevelopmental diseases, Angelman syndrome and autism.
(Nature, )

Skin is the second most common organ (after the kidney) to be affected in patients with systemic lupus erythematosus (SLE), yet the aetiology of skin injury and the mechanisms involved in the development of dermal manifestations of SLE remain unclear.
(Nature Reviews Rheumatology, )

The discovery of the central nervous system lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
(Nature, )

Accumulating evidence suggests that the human intestinal microbiota contributes to the aetiology of colorectal cancer (CRC), not only via the pro-carcinogenic activities of specific pathogens but also via the influence of the wider microbial community, particularly its metabolome.
(Nature Reviews Microbiology, )

Other sentences

27 examples:

Aetiology of colitis is highly complex and incompletely understood.
(Nature Communications, )

Systemic sclerosis (SSc) is a complex autoimmune disease of unclear aetiology.
(Nature Reviews Rheumatology, )

The aging myopathy is characterized by diastolic dysfunction of unknown aetiology.
(Nature Communications, )

Patients with myotonic dystrophy (MD) suffer from severe cardiac issues of unknown aetiology.
(Nature Communications, )

Diffuse large B-cell lymphoma is an aggressive heterogeneous tumour type with poorly understood aetiology.
(Nature Communications, )

Complex regional pain syndromes (CRPS) are multifactorial disorders with complex aetiology and pathogenesis.
(Nature Reviews Neurology, )

Polymyalgia rheumatica (PMR) is an inflammatory disorder of unknown aetiology that can be extremely disabling when active.
(Nature Reviews Rheumatology, )

Basal-like breast cancer is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood.
(Nature Communications, )

Female sexual dysfunction (FSD) is a controversial condition, which has prompted much debate regarding its aetiology, components, and even its existence.
(Nature Reviews Urology, )

Here, the authors show that de novo missense mutations, but not inherited missense mutations, in TBR1 disrupt the protein function and contribute to ASD aetiology.
(Nature Communications, )

More than half of the patients who have suffered a stroke with no well-defined aetiology have an enlarged left atrial appendage of the heart, according to a study.
(Science Daily - News, )

Here the authors carry out a fine-mapping analysis of the major histocompatibility complex region and identify amino acids that have a causal role in SLE aetiology.
(Nature Communications, )

Here, the authors present experimental zebrafish models of idiopathic and congenital scoliosis and suggest a role for dysregulated Wnt activity in scoliosis aetiology.
(Nature Communications, )

The developmental aetiology of autism spectrum disorders (ASDs) is poorly understood — partly because of the difficulty in accurately modelling human cortical development.
(Nature Reviews Neuroscience, )

Here, the authors carry out a genome-wide association analysis in HL patients and healthy controls; identifying a new HL risk locus and implicating TCF3 in the disease aetiology.
(Nature Communications, )

Rheumatoid arthritis (RA) is a prototype for a criterion-defined inflammatory disease, for which the aetiology and initial molecular pathogenesis has been elusive for a long time.
(Nature Reviews Rheumatology, )

Recognition of myoclonus and determination of the underlying aetiology remains challenging given that both acquired and genetically determined disorders have varied manifestations.
(Nature Reviews Neurology, )

Genomic studies have greatly advanced our understanding of the multifactorial aetiology of type 2 diabetes mellitus (T2DM) as well as the multiple subtypes of monogenic diabetes mellitus.
(Nature Reviews Endocrinology, )

Here the authors demonstrate that the differential regulation of eIF4E1 and eIF4E3 by the MAPK-interacting kinases is involved in DLBCL aetiology through modification of the cellular translatome.
(Nature Communications, )

Here, the authors clone brain-expressed alternatively-spliced isoforms of ASD risk factors and construct a network of protein interactions that provides further insight into the disease aetiology.
(Nature Communications, )

Genome-wide association studies (GWASs) have become the focus of the statistical analysis of complex traits in humans, successfully shedding light on several aspects of genetic architecture and biological aetiology.
(Nature Reviews Genetics, )

Recent evidence suggests that narcolepsy, a disorder that results from the loss of orexinergic neurons of the lateral hypothalamus, has an autoimmune aetiology, but the underlying mechanisms have not been elucidated.
(Nature Reviews Neuroscience, )

The updated nomenclature for vasculitis defines this varied group of disorders by aetiology, specific features of pathogenesis and clinical symptoms; diagnostic and classification criteria for clinical practice are in development.
(Nature Reviews Rheumatology, )

JIA-associated uveitis is recognized to have an autoimmune aetiology characterized by activation of CD4+ T cells, but the underlying mechanisms might overlap with those of autoinflammatory conditions involving activation of innate immunity.
(Nature Reviews Rheumatology, )

In 2014, novel, large-scale collaborative efforts and frameworks resulted in major advances in the epilepsy field, from publication of a new definition of epilepsy to important discoveries regarding aetiology, pathophysiology and management.
(Nature Reviews Neurology, )

The new MOGE(S) classification system, which incorporates information on structural and functional abnormalities, organ involvement, genetics, aetiology, and disease severity, is a step towards a globally accepted nomenclature, but needs to be applicable in all health-care systems around the world.
(Nature Reviews Cardiology, )

In 2015, large-scale genetic and functional studies brought us closer to understanding the underlying aetiology of polycystic ovary syndrome (PCOS), implicating genes involved in modulation of gonadotropin and neuroendocrine action, ovarian androgen biosynthesis and possibly insulin action, providing clues to the evolutionary path and potential evolutionary advantages of PCOS.
(Nature Reviews Endocrinology, )

Other examples

See also examples for aetiologies.

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