Examples of Afferent
Chemogenetic stimulation of these afferent neurons in sated mice markedly activates AgRP neurons and induces intense feeding.
Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons.
(Nature Communications, )
Peixoto et al. show that Shank3B−/− mice exhibit premature development and subsequent arrest of striatal afferent connectivity.
(Nature Neuroscience, )
Discovery of these afferent neurons capable of triggering hunger advances understanding of how this intense motivational state is regulated.
However, whether Merkel cells or afferent fibres themselves sense mechanical force is still debated, and the molecular mechanism of mechanotransduction is unknown.
Dysfunctional afferent signalling can result in hypersensitive bladder disorders such as overactive bladder (OAB) or interstitial cystitis/bladder pain syndrome (IC/BPS).
(Nature Reviews Urology, )
Pinprick response is a longstanding feature of the clinical examination for spinal cord damage, but this test cannot target every afferent pathway in the spinothalamic tract.
(Nature Reviews Neurology, )
Merck (known as MSD outside the United States and Canada) has announced it will acquire Afferent Pharmaceuticals in a deal worth up to US$1.25 billion in upfront and milestone payments (Fig. 1).
(Nature Reviews Drug Discovery, )
Merck & Co. has agreed to purchase biotechnology company Afferent Pharmaceuticals, whose lead drug candidate is being evaluated as a treatment for refractory, chronic cough and idiopathic pulmonary fibrosis with cough.
(The Wall Street Journal - U.S. Business, )
In response to signals from afferent TRPV1+ C-fibers, STAT3-dependent upregulation of LCN2 in reactive astrocytes of the spinal dorsal horn amplifies itch signaling in multiple rodent models of atopic and contact dermatitis.
(Nature Medicine, )
Bipolar tail neuron precursors derive from caudal neural plate border cells, delaminate and migrate along the paraxial mesoderm on either side of the neural tube, eventually differentiating into afferent neurons that form synaptic contacts with both epidermal sensory cells and motor neurons.
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