Examples of agonistic
Here we show the crystal structures of three forms of TLR9: unliganded, bound to agonistic CpG-DNA, and bound to inhibitory DNA (iDNA).
Optogenetic manipulations indicated that Esr1+ (but not Esr1−) neurons are sufficient to initiate attack, and that their activity is continuously required during ongoing agonistic behaviour.
Strategies that deplete (anti-CSF-1 antibodies and CSF-1R inhibition) or stimulate (agonistic anti-CD40 or inhibitory anti-CD47 antibodies) tumour-associated macrophages have had some success.
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