Examples of allylic
Here we report the use of both photoredox and organic catalysis to accomplish a mild, broadly effective direct allylic C–H arylation.
Within this context, the discovery of chemical transformations that are able to directly functionalize allylic methyl, methylene and methine carbons in a catalytic manner is a priority.
Here, the authors show a catalytic asymmetric process for the addition of sulphur ylides to cyclic allylic esters with loss of CO 2, giving access to chiral, highly functionalised indolines.
(Nature Communications, )
In particular, the direct arylation of non-functionalized allylic systems would enable access to a series of known pharmacophores (molecular features responsible for a drug’s action), though a general solution to this long-standing challenge remains elusive.
A persisting problem, however, is the dearth of chemical transformations that directly generate acyclic Z allylic alcohols, including products that contain a hindered neighbouring substituent or reactive functional units such as a phenol, an aldehyde, or a carboxylic acid.
Although protocols for direct oxidation and amination of allylic C–H bonds (that is, C–H bonds where an adjacent carbon is involved in a C = C bond) have become widely established, the engagement of allylic substrates in C–C bond forming reactions has thus far required the use of pre-functionalized coupling partners.
Don't miss the pronunciation examples of allylic to learn how to say it correctly!
Share this page
Go to the pronunciation of allylic to learn how to say it correctly!