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Examples of Amide


13 examples:

Fatty acid amide hydrolase (FAAH) is a key regulator of endocannabinoid signalling.
(Nature Communications, )

Here we demonstrate that amide carbon–nitrogen bonds can be activated and cleaved using nickel catalysts.
(Nature, )

Amides are known to be poor electrophiles, which is typically attributed to the resonance stability of the amide bond.
(Nature, )

Amide formation is a ubiquitous reaction in organic chemistry, but suffers from the problem of generating large amounts of waste.
(Nature Communications, )

Transamidation reactions are kinetically and thermodynamically challenging because of the stability of the amide starting materials.
(Nature Communications, )

Cyclodepsipeptides are cyclic peptides in which one or more amide groups are replaced with an ester; they have diverse biological functions.
(Nature Protocols, )

Here, the authors provide experimental evidence for this autoionization process at high pressures, showing the transformation of molecular ammonia into ammonium amide.
(Nature Communications, )

Although amides can readily be cleaved by enzymes such as proteases, it is difficult to selectively break the carbon–nitrogen bond of an amide using synthetic chemistry.
(Nature, )

Here, the authors show a two-step process—activation of a secondary amide, followed by nickel-catalysed C–N bond cleavage—that allows mild and high yielding transamidation.
(Nature Communications, )

Here, the authors report a catalytic amide synthesis by the ruthenium catalysed addition of carboxylic acids to acetylenes, followed by reaction with primary or secondary amines.
(Nature Communications, )

Our approach employs a simple N-methoxy amide group, which serves as both a directing group and an anionic ligand that promotes the in situ generation of the reactive PdX2 (X = ArCONOMe) species from a Pd(0) source using air as the sole oxidant.
(Nature, )

Our results provide a way to harness amide functional groups as synthetic building blocks and are expected to lead to the further use of amides in the construction of carbon–heteroatom or carbon–carbon bonds using non-precious-metal catalysis.
(Nature, )

Here we describe a network of biologically relevant organic reactions (amide formation, thiolate–thioester exchange, thiolate–disulfide interchange and conjugate addition) that displays bistability and oscillations in the concentrations of organic thiols and amides.
(Nature, )

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